Endoscopic full-thickness resection of gastric stromal tumor: one and done

Xu, Mingming; Angeles, Alejandro; Kahaleh, Michel

doi:10.1055/s-0043-121566

Cited by 12 publications

(4 citation statements)

References 4 publications

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“…The mainstay of Eo-EFTR is a safe wall defect closure after excision to prevent peritonitis and further surgical interventions. Currently, this is mainly achieved by use of standard through-the-scope clips [10] or clips combined with endoloops [11,12], whereas defect closure by use of over-the-scope clips or endoscopic suturing devices has been reported in only a few cases [13][14][15][16][17][18][19].…”

mentioning

confidence: 99%

Efficacy and safety of gastric exposed endoscopic full-thickness resection without laparoscopic assistance: a systematic review

et al. 2020

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Background and study aims Exposed endoscopic full-thickness resection (Eo-EFTR) without laparoscopic assistance is a minimally invasive natural orifice transluminal endoscopic surgery (NOTES) technique that has shown promising efficacy and safety in resection of gastric submucosal tumors (G-SMTs) arising from muscularis propria (MP). However, data on the efficacy and safety of gastric Eo-EFTR mostly come from relatively small retrospective studies and concern regarding its use still exists. The aim of our systematic review was to assess the efficacy and safety of gastric Eo-EFTR without laparoscopic assistance. Methods A detailed MEDLINE and EMBASE search was performed for papers published from January 1998 to November 2019 and reporting on gastric Eo-EFTR without laparoscopic assistance. The search strategy used the terms “endoscopic full thickness resection” and “gastric” or “stomach”. The primary outcomes were complete resection and surgical conversion rates. The secondary outcomes were overall major adverse events, delayed bleeding, delayed perforation, peritonitis, abdominal abscess and/or abdominal infection and successful Eo-EFTR. Results Fifteen Asian studies were included in our final review, providing data on 750 Eo-EFTR-treated G-SMTs. The per-lesion rate of complete resection and surgical conversion were 98.8 %\0.8 %, respectively. The per-lesion rate of major adverse events, delayed bleeding, delayed perforation and peritonitis, abdominal abscess and/or abdominal infection was 1.6 %\0.5 %\0.1 %\0.9 %, respectively. The per-lesion rate of successful Eo-EFTR (i. e. complete tumor resection and effective endoscopic defect closure) was 98.3 %. Conclusions Eo-EFTR without laparoscopic assistance appears to be highly effective and safe NOTES for removing deep G-SMTs, particularly those arising from MP layer.

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confidence: 99%

Efficacy and safety of gastric exposed endoscopic full-thickness resection without laparoscopic assistance: a systematic review

et al. 2020

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“…17 Relapse occurs in around 50% of individuals even after radical surgical treatment. 18 Patients with NF1 and those with sporadic GIST have similar recurrence rates. Laparoscopic surgery is also becoming common, with less procedure-related pain, faster recovery, and shorter hospital stays.…”

Section: Discussionmentioning

confidence: 99%

A rare case presentation of neurofibromatosis type 1 with multiple gastrointestinal stromal tumors: a case report

Pathak,

Rajesh,

Chavda

et al. 2024

Int Surg J

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Neurofibromatosis type 1 (NF1), a hereditary cancer predisposing syndrome is an autosomal dominant disorder. Gastrointestinal stromal tumor (GIST) is the most prevalent non-neurological tumor in these individuals. In NF1-associated GIST, KIT and platelet-derived growth factor receptor α (PDGFRA) mutations might not be present, and Imatinib may not be effective. Surgical resection is the first-line treatment. The primary aim was to include the possibility of rare tumors including GIST in neurofibromatosis patients in the differential diagnosis of GIT pathology/presentation. A 50-year-old male with neurofibromatosis came with complaints of dull aching abdominal pain and on further investigation was found to have lesions in the distal small bowel, suspicious of nerve sheath tumors, in abdominal computed tomography. A laparotomy was performed and the jejunum containing nodular lesions was resected and pathologically diagnosed as GIST. The patient was then started on Imatinib. At the 6-month follow-up, no tumor recurrence was visible. The rare and unusual location of multiple GIST in neurofibromatosis patients underscores its importance in differential diagnosis, and our case report on the patient's therapy and the clinical outcome could aid in patient care.

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“…Complete removal without lymph node dissection is recommended[ 13 ]. Even after radical surgical treatment, approximately 50% of patients experience relapse[ 14 ]. The recurrence rate in patients with NF1 is similar to that in patients with sporadic GIST.…”

Section: Discussionmentioning

confidence: 99%

Neurofibromatosis type 1 with multiple gastrointestinal stromal tumors: A case report

Yao¹,

Jiang²,

Yi³

et al. 2023

World J Clin Cases

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BACKGROUND Neurofibromatosis type 1 (NF1) is characterized by café-au-lait patches on the skin and the presence of neurofibromas. Gastrointestinal stromal tumor (GIST) is the most common non-neurological tumor in NF1 patients. In NF1-associated GIST, KIT and PDGFRA mutations are frequently absent and imatinib is ineffective. Surgical resection is first-line treatment. CASE SUMMARY A 56-year-old woman with NF1 was hospitalized because of an incidental pelvic mass. Physical examination was notable for multiple café-au-lait patches and numerous subcutaneous soft nodular masses of the skin of the head, face, trunk, and limbs. Her abdomen was soft and nontender. No masses were palpated. Digital rectal examination was unremarkable. Abdominal computed tomography was suspicious for GIST or solitary fibrous tumor. Laparoscopy was performed, which identified eight well-demarcated masses in the jejunum. All were resected and pathologically diagnosed as GISTs. The patient was discharged on day 7 after surgery without complications. No tumor recurrence was evident at the 6-mo follow-up. CONCLUSION Laparoscopy is effective for both diagnosis and treatment of NF1-associated GIST.

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Endoscopic full-thickness resection of gastric stromal tumor: one and done

Cited by 12 publications

References 4 publications

Efficacy and safety of gastric exposed endoscopic full-thickness resection without laparoscopic assistance: a systematic review

Efficacy and safety of gastric exposed endoscopic full-thickness resection without laparoscopic assistance: a systematic review

A rare case presentation of neurofibromatosis type 1 with multiple gastrointestinal stromal tumors: a case report

Neurofibromatosis type 1 with multiple gastrointestinal stromal tumors: A case report

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