Endoscopic Mucosal Resection in the Esophagus with a New Rigid Device: an Animal Study

Abstract

This EMR method offers a promising approach in comparison with other options currently available. It appears to be superior in terms of the size of the resected specimen, the precision and regularity of the resection depth, and the accuracy of histological diagnosis with safety margins. Hemicircumferential EMRs have been shown to be safe in the sheep model. This new technique warrants further animal studies before being used for circumferential EMR in humans.

Prevention and Treatment of Esophageal Stenosis after Endoscopic Submucosal Dissection for Early Esophageal Cancer

“…However, the residual mucosal defect after the procedure may cause acute inflammation, deep ulcers, local submucosal fibrous connective tissue proliferation, collagen deposition, esophageal wall fibrosis, and even esophageal stricture formation [3]. The incidence of esophageal strictures after endoscopic resection for near-circumferential or circumferential esophageal large mucosal defects has been extremely high at 88–100% [4–9].…”

Feasibility study of corticosteroid treatment for esophageal ulcer after EMR in a canine model

“…Recent advances in therapeutic techniques using endoscopy have now made it possible to resect widespread esophageal lesions [3]. However, postoperative mucosal defects can lead to severe inflammation, deep artificial ulceration, and fibrosis of the esophageal wall [4]. After mucosal resection for widespread lesions, especially in cases involving circumferential resection, patients often develop refractory esophageal stricture and need to undergo periodic balloon dilatation [5][6][7].…”

Initial experience with Barrett’s strip endoscopic mucosal excision: a new Barrett’s excision device

“…In a pilot study, Radu et al [4] used a rigid esophagoscope and a diathermy wire loop to perform esophageal mucosal resection in sheep. The mucosa was captured by vacuum and excised by a nonadjustable curvilinear cautery wire.…”