Endoscopic submucosal dissection combined with orally administered dimethyl sulfoxide for primary gastric localized amyloidosis

Jin, Shizhu; Han, Mingzhe; Cheng, Yanqiu; Liang, Guoying; Chu, Yanjie; Zhu, Fang; Liu, Bing-Rong

doi:10.1016/j.clinre.2014.01.002

Cited by 8 publications

(8 citation statements)

References 8 publications

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“…So far there has been only one case of localized gastric amyloidosis presenting two separate lesions with different morphology. 5 However, that case was more aggressive one with epigastric pain and was treated endoscopically. On the contrary, our case was asymptomatic and continued good condition without any treatment for 10 months.…”

Section: Discussionmentioning

confidence: 94%

Asymptomatic Localized Gastric Amyloidosis with Two Separate Lesions

Lim

Kim

Seo

et al. 2018

Korean J Helicobacter Up Gastrointest Res

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Amyloidosis is a disease in which amyloid is abnormally accumulated in the tissue. The kidney and heart are the most commonly involved organs. Gastric involvement is relatively common in systemic disease; however, localized gastric amyloidosis is rare. Here, we report a case of localized gastric amyloidosis with two separate lesions. A 56-year-old woman underwent a health surveillance checkup without any noticeable symptoms. She was under medication for diabetes and dyslipidemia, and was otherwise healthy. On surveillance upper endoscopy, an irregularly shaped hyperemic elevated erosion at the gastric fundus and a 1.5-cm, yellowish subepithelial tumor-like lesion with intact overlying mucosa at the lesser curvature of the lower body of the stomach were detected. Endoscopic biopsy revealed submucosal eosinophilic material deposition in both lesions. Congo-red staining showed amyloid deposit appearing as a yellow-green birefringence under polarizing microscopy. Echocardiography, abdominal sonography, and colonoscopy revealed no abnormality. The patient was diagnosed as having localized gastric amyloidosis and is now undergoing regular follow-up without any treatment. Localized gastric amyloidosis is a rare disease that may mimic nonspecific gastritis or subepithelial tumor. However, endoscopic biopsy with appropriate staining may be diagnostic and thorough evaluation for systemic involvement is important.

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Section: Discussionmentioning

confidence: 94%

Asymptomatic Localized Gastric Amyloidosis with Two Separate Lesions

Lim

Kim

Seo

et al. 2018

Korean J Helicobacter Up Gastrointest Res

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“…Three cases including this case are compared in Table 1 . [ 3 , 4 ] In general, localized amyloidosis has a good prognosis and is known to be less likely to recur when treated. [ 11 ] For this reason, many localized amyloidosis were just observed or treated symptomatically.…”

Section: Discussionmentioning

confidence: 99%

Localized gastric amyloidosis successfully treated with endoscopic submucosal dissection

Park

Kim

et al. 2021

Medicine

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Rationale: Amyloidosis is a general term that refers to the extracellular deposition of amyloid. The amyloid can also be deposited in a single organ. However, cases of localized gastric amyloidosis have rarely been reported. Here, we report a case of localized gastric amyloidosis that was successfully treated with endoscopic submucosal dissection. Patient concern: A 60-years-old man underwent esophagogastroduodenoscopy as part of a regular check-up without any comorbidities or symptoms. Diagnostics: A 12 mm-sized, round, elevated lesion with a central depression, which was covered with normal mucosa, and located on the greater curvature of the lower body of the stomach was discovered during endoscopy. Subsequently, endoscopic ultrasonography was performed, which revealed a 11.7 mm-sized, hypoechoic, heterogeneous lesion located in the muscularis mucosa and submucosa. A biopsy was performed, and amyloid deposition was confirmed. Although other investigations for checking systemic amyloidosis were performed, there were no specific findings. Therefore, the final diagnosis was localized gastric amyloidosis. Interventions: Endoscopic submucosal dissection was performed according to the patient's request and the lesion was completely removed. Outcomes: The patient was followed-up for 3 years without any recurrence. Conclusions: Endoscopic submucosal dissection can be good diagnostic and treatment option for localized gastric amyloidosis.

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“…Gastrointestinal involvement is common in amyloidosis; however, most cases are systematic amyloidosis, and local deposits of amyloid in the gastrointestinal tract without systemic involvement is uncommon (5). Amyloidosis limited to the stomach is relatively rare (2,(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17). To our knowledge, there have been 11 case reports with follow-up after the initial diagnosis (Table) LGA but finally diagnosed as plasmacytoma with amyloid deposits at 2 years after the initial diagnosis (3).…”

Section: Discussionmentioning

confidence: 99%

“…The EUS findings of LGA are not consistent (8,11,12), and few studies have compared EUS images with the pathology. In the present case, ESD enabled us to compare the EUS findings with the corresponding pathology.…”

Section: Discussionmentioning

confidence: 99%

Localized Gastric Amyloidosis that Displayed Morphological Changes over 10 Years of Observation

et al. 2021

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We herein report an extremely rare case of localized gastric amyloidosis (LGA) with morphological changes during the follow-up. A 71-year-old woman who had a depressed lesion with central elevation in the gastric lower body was diagnosed with LGA. Esophagogastroduodenoscopy at 10 years after the initial examination showed that the lesion had grown and changed morphologically, exhibiting a submucosal tumorlike appearance. Since the lesion was confined to the submucosa, the patient underwent endoscopic submucosal dissection. The final pathological diagnosis was amyloid light-chain (AL)-type LGA. This case may provide useful information regarding the natural history of AL-type LGA.

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Endoscopic submucosal dissection combined with orally administered dimethyl sulfoxide for primary gastric localized amyloidosis

Cited by 8 publications

References 8 publications

Asymptomatic Localized Gastric Amyloidosis with Two Separate Lesions

Asymptomatic Localized Gastric Amyloidosis with Two Separate Lesions

Localized gastric amyloidosis successfully treated with endoscopic submucosal dissection

Localized Gastric Amyloidosis that Displayed Morphological Changes over 10 Years of Observation

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