Endoscopic submucosal dissection for superficial esophageal neoplasms in elderly patients: A single‐center, large‐scale, retrospective study

Noh, Jin Hee; Gong, Eun Jeong; Kim, Do Hoon; Na, Hee Kyong; Ahn, Ji Yong; Lee, Jeong Hoon; Jung, Kee Wook; Choi, Kee Don; Song, Ho June; Lee, Gin Hyug; Jung, Hwoon‐Yong

doi:10.1111/ggi.13892

Cited by 5 publications

(2 citation statements)

References 32 publications

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“…Noh et al. ( 19 ) reported no patients over 75 years were selected for additional surgery; however, Ishido et al. ( 20 ) reported several treatments including surgery.…”

Section: Stagementioning

confidence: 99%

Management of elderly patients with esophageal squamous cell cancer

Hamamoto

Murakami

Kato

et al. 2022

Japanese Journal of Clinical Oncology

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This review focuses on the treatment about elderly esophageal cancer to clarify the current situation regarding our clinical question. Although there are several reviews about elderly esophageal cancer treatment, there are fundamental differences between Japan and the rest of the world. Two main differences are raised: histological differences and treatment strategies for resectable patients. We overview each status according to following clinical questions. First, there are no established evaluation criteria for frail. Second, selection criteria for surgery or non-surgery are not established. Third, few specific treatments for elderly patients (EPs) are investigated. In conclusion, there are many reports about treatment of esophageal squamous cell carcinoma for EPs, although treatment strategy is still controversial. We have to consider well-designed prospective trial to confirm specific treatment strategy according to each stage.

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“…Noh et al. ( 19 ) reported no patients over 75 years were selected for additional surgery; however, Ishido et al. ( 20 ) reported several treatments including surgery.…”

Section: Stagementioning

confidence: 99%

Management of elderly patients with esophageal squamous cell cancer

Hamamoto

Murakami

Kato

et al. 2022

Japanese Journal of Clinical Oncology

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“…Several previous reports including long-term follow-up have identified ESD as a favorable treatment modality for the curative resection of SEC [ 25 - 32 ]. In a meta-analysis of 21 studies of ESD in the treatment of early EC, the pooled en bloc resection rate was 99% [ 33 ].…”

Section: Long-term Outcomesmentioning

confidence: 99%

Endoscopic Resection for the Treatment of Superficial Esophageal Neoplasms

Kim

Jung

2020

Korean J Thorac Cardiovasc Surg

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Superficial esophageal neoplasms (SENs) are being diagnosed increasingly frequently due to the screening endoscopy and advances in endoscopic techniques. Endoscopic resection (ER) is a relatively noninvasive treatment method with low morbidity and mortality that provides excellent oncologic outcomes. Endoscopic submucosal dissection is associated with higher rates of en bloc, complete and curative resections and lower rates of local recurrence than endoscopic mucosal resection. The most serious complication of ER is stricture, the treatment and prevention of which are crucial to maintain the patient's quality of life. ER for SEN is feasible, effective, and safe and can be considered a first-line treatment for SENs in which it is technically feasible.

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Safety and usefulness of endoscopic submucosal dissection for early esophageal cancers in elderly patients aged 80 years or older

et al. 2020

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Background and Aim: Endoscopic submucosal dissection (ESD) for early gastrointestinal (GI) cancers is widely performed as a standard treatment in Japan. Given the increasing life expectancy worldwide, it is naturally regarded that the rate of elderly patients diagnosed with early GI cancer has increased. Available guidelines do not specifically outline how to manage endoscopic therapy for the elderly. The aim of this study was to assess the safety and usefulness of ESD for superficial esophageal squamous cell carcinoma (SESCC) in elderly patients.Methods: We retrospectively investigated 393 consecutive patients, who underwent 426 ESD for 444 SESCCs from January 2011 to August 2016 at our institution. For this study, patients were divided into 2 groups based on their age; ≥ 80 years (Group aged 80 years, n = 42) and < 80 years (Group aged <80 years, n = 351).Patient demographics, sedation methods, technical outcomes, adverse events, sedatives, dosages given, overall survival and disease specific survival were then examined.Results: The ESD procedure time was significantly longer for group aged 80 years than for group aged <80 years (110 minutes [range, 29-260] vs 85 minutes [24-504], p=0.006), however there was no significant differences between other technical items and adverse events. The 3-year overall survival and disease specific survival were favorable in both groups.Conclusions: Esophageal ESD for elderly patients aged 80 years can be safely performed. Mid-term outcome was favorable. Our study suggests that esophageal ESD might be a usefulness treatment for SESCCs.

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Endoscopic submucosal dissection for superficial esophageal neoplasms in elderly patients: A single‐center, large‐scale, retrospective study

Cited by 5 publications

References 32 publications

Management of elderly patients with esophageal squamous cell cancer

Management of elderly patients with esophageal squamous cell cancer

Endoscopic Resection for the Treatment of Superficial Esophageal Neoplasms

Safety and usefulness of endoscopic submucosal dissection for early esophageal cancers in elderly patients aged 80 years or older

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