Endoscopic survey of low‐dose‐aspirin‐induced gastroduodenal mucosal injuries in patients with ischemic heart disease

Nema, Hiroaki; Kato, Mototsugu; Katsurada, Takehiko; Nozaki, Youichi; Yotsukura, Akihiko; Yoshida, Izumi; Sato, Katsuhiko; Kawai, Yuko; Takagi, Yasushi; Okusa, Takanori; Takiguchi, Shunichi; Sakurai, Minoru; Asaka, Masahiro

doi:10.1111/j.1440-1746.2008.05411.x

Cited by 21 publications

(16 citation statements)

References 12 publications

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“…23 In a study in Japan, it was found that 61.4% long-term low-dose aspirin users suffered from gastroduodenal mucosal injury and in 18.8% patients, ulcers were identified. 8 However, there was no association between the duration of aspirin use with the frequency of mucosal injury. 8 The dose of aspirin being used in the study performed by Nema et al was 80-100 mg. 8 While, in the study conducted by Yeomans et al was 144 ± 9 mg.…”

Section: Discussionmentioning

confidence: 93%

“…8 However, there was no association between the duration of aspirin use with the frequency of mucosal injury. 8 The dose of aspirin being used in the study performed by Nema et al was 80-100 mg. 8 While, in the study conducted by Yeomans et al was 144 ± 9 mg. Subjects in this study also used the similar dose of aspirin, which was 80-160 mg. A study which used patients' data in England concluded that there was no significant difference of gastroduodenal mucosal injury in patients who used aspirin with the dose of 75 mg up to 300 mg. 24 Mucosal injuries could even happen in aspirin administration with the dose of 10 mg for more than 3 months.…”

Section: Discussionmentioning

confidence: 93%

“…19 A study in Japan described that most patients' age were more than 65 years old, with average age of 68.9 ± 10.3 years old. 8 This was caused by the use of low-dose aspirin to prevent cardiovascular and cerebrovascular diseases which increased with the increase of age. Forty-six patients (48.4%) did not have dyspepsia complaints during the administration of long-term low-dose aspirin.…”

Section: Discussionmentioning

confidence: 99%

“…6 Based on previous studies, mucosal erosion took place in approximately 60% of aspirin users, while peptic ulcer was found in 11-19% patients. 7,8 However, more studies associated the use of aspirin with gastrointestinal bleeding. [9][10][11][12][13][14] In a large study involving 27,694 patients, upper gastrointestinal bleeding was found in 2.6% of aspirin users.…”

Section: Introductionmentioning

confidence: 99%

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Gastroduodenal Mucosal Injury Profile in Long-Term Low-Dose Aspirin Users and Its Influencing Factors

Franciscus

Syam

Makmun

et al. 2017

InaJGHE

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Background: Low-dose aspirin is the most common drug used for prevention of cardiovascular and cerebrovascular events. Long-term aspirin therapy can induce gastroduodenal mucosal injury, even in a very low dose (10 mg daily). The frequency of gastroduodenal injuries among long-term low-dose aspirin users in (OR = 3.3;). However, proton pump inhibitor (PPI) decreased the risk of mucosal injury (OR = 0,2; 95% CI: 0,60

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Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Gastroduodenal Mucosal Injury Profile in Long-Term Low-Dose Aspirin Users and Its Influencing Factors

Franciscus

Syam

Makmun

et al. 2017

InaJGHE

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“…The prevalence of gastroduodenal lesions may not be dependent on the duration of aspirin administration. Most low-dose aspirin users with gastroduodenal injuries are asymptomatic till their progressive patterns appear (4). Therefore, an endoscopic evaluation of this side effect in this population is vital.…”

Section: Introductionmentioning

confidence: 99%

Relationship between continuous use of low-dose enteric-coated aspirin and gastrointestinal injuries in patients with gastrointestinal hemorrhage

Mousavi

Salehimarzijarani²,

Dadvar³

et al. 2013

Turk J Gastroenterol

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Amaç: Gastrointestinal bozukluklar, düflük doz enterik-kapl› formu kullan›lsa bile aspirin tedavisinin hayati yan etkilerindendir. Bu çal›flman›n amac›, gastrointestinal kanamal› hastalarda düflük doz enterik-kapl› aspirine ba¤l› üst ve alt endoskopik bulgula Background/aims: Gastrointestinal disorders are important side effects of aspirin therapy, even if the low-dose enteric-coated form is administered. The aim of the current study was to present the upper and lower endoscopic features of patients with gastrointestinal hemorrhage using low-dose enteric-coated aspirin. Materials and Methods: This prospective study was conducted among 633 consecutive patients with gastrointestinal hemorrhage who admitted to our tertiary referral hospital for endoscopy assessment. Patients were divided into two groups as low-dose aspirin users (n=168) and non-aspirin users (n=495). Aspirin users included tho-

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Factors associated with the initiation of proton pump inhibitors in corticosteroid users

Munson

Wahl

Daniel

et al. 2012

Pharmacoepidemiology and Drug

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Purpose Proton pump inhibitors (PPIs) and corticosteroids are commonly prescribed drugs; however, each has been associated with fracture and community acquired pneumonia. How physicians select patients for co-therapy may have implications for potential additive or synergistic toxicities. Methods We conducted a retrospective cohort study of 13,749 incident corticosteroid users with no prior PPI exposure using the HealthCore Integrated Research DatabaseSM. We used logistic regression to evaluate the association between PPI initiation in the first 30 days of steroid therapy and corticosteroid dose, clinical risk factors including co-morbid diseases, and medication use including prescription nonsteroidal anti-inflammatory drugs (NSAIDs). Results 1,050 (7.6%) patients filled a new PPI prescription within 30 days of starting corticosteroids. PPI use was associated with the number of baseline co-morbid conditions (OR 1.21 for each additional condition, CI 1.13–1.28), recent hospitalization (OR 4.71, CI 4.02–5.52), prednisone dose above 40mg/day (OR 1.87, CI1.45–2.41), history of gastroesophageal reflux or gastric ulcer disease (OR 1.54, CI 1.24– 1.91), renal insufficiency (OR 2.06, CI 1.73–2.46), and liver disease (OR 1.82, CI 1.45–2.28). Concomitant use of prescription NSAIDs was also associated with PPI use (OR 1.89, CI 1.32–2.70); however, the total use of PPIs in this group was low (6.3%, CI 4.4–8.2%). Conclusions Overall, PPI therapy among corticosteroid users was uncommon, even among those with risk factors for gastrointestinal toxicity. PPI use was significantly more common among patients who had recently been hospitalized, had a greater burden of co-morbid illness, or were receiving high daily doses of corticosteroids.

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Endoscopic survey of low‐dose‐aspirin‐induced gastroduodenal mucosal injuries in patients with ischemic heart disease

Abstract: Endoscopy frequently reveals low-dose aspirin-induced gastroduodenal injuries in patients with IHD.

Cited by 21 publications

References 12 publications

Gastroduodenal Mucosal Injury Profile in Long-Term Low-Dose Aspirin Users and Its Influencing Factors

Gastroduodenal Mucosal Injury Profile in Long-Term Low-Dose Aspirin Users and Its Influencing Factors

Relationship between continuous use of low-dose enteric-coated aspirin and gastrointestinal injuries in patients with gastrointestinal hemorrhage

Factors associated with the initiation of proton pump inhibitors in corticosteroid users

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