Endoscopic Ultrasonography–Guided Fine Needle Aspiration Biopsy for Staging Malignant Melanoma of the Esophagus

Holck, Susanne; Siemsen, Mette; Jensen, Dennis Bo; Mogensen, Anne Mellon

doi:10.1159/000326989

Cited by 5 publications

(6 citation statements)

References 18 publications

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“…We procured the paraffin tissue blocks of this case and performed IHC with desmin, S100, and Melan-A, of which the latter two markers were strongly positive (figures 5&6), confirming our cytologic suspicion of melanoma (Siddaraju et al, 2007). Other unusual cytologic features described by the various authors are the papillary fragments with fibrovascular cores (Baloch et al, 1999), myxoid stroma (Elliot et al, 2001) ballon cells (Friedman et al, 1982), signet ring cells (Siddaraju et al, 2007) with pseudolipoblastic appearance (Holck et al, 2002), cells with rhabdoid features (Slagel et al, 1997) and cells arranged in alveolar pattern . Although rare, a divergent differentiation such as chondroid, neural, myofibroblastic, and osteocartilagenous differentiation is well known in melanomas; and the lack of awareness of this fact can create serious diagnostic problems to the evaluator.…”

Section: Microscopic Examination Of Cytologic Samplessupporting

confidence: 71%

Clinical Cytology in the Diagnosis and Management of Melanoma

Siddaraju¹

2011

Current Management of Malignant Melanoma

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Section: Microscopic Examination Of Cytologic Samplessupporting

confidence: 71%

Clinical Cytology in the Diagnosis and Management of Melanoma

Siddaraju¹

2011

Current Management of Malignant Melanoma

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“…7 An endoscopic ultrasound-guide fi ne-needle aspiration biopsy has been reported to be useful not only for diagnosing submucosal lesions but also for accurately staging malignant melanoma of the esophagus. 8 More recently, FDG-PET scans have been used to detect an increased radiotracer uptake in the lesions of malignant melanoma and to more accurately evaluate the metastatic lesions. 9 When the diagnosis is uncertain, these techniques may also contribute to the early identifi cation of PMME.…”

Section: Discussionmentioning

confidence: 99%

Primary Malignant Melanoma of the Esophagus Arising from a Melanotic Lesion: Report of a Case

et al. 2007

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We herein report a case of primary esophageal malignant melanoma in which the development from a preceding benign melanotic lesion and the growing process of the tumor were chronologically observed by serial endoscopic examinations. Biopsy specimens repeatedly taken from the tumor failed to identify the presence of malignant melanoma. A positron emission tomography scan and gross changes of the tumor endoscopically observed were useful for detecting the presence of malignant transformation. The patient eventually died of generalized metastatic disease soon after undergoing an esophagectomy. An early diagnosis may therefore be crucial for improving the treatment outcome of esophageal malignant melanoma. Therefore, esophageal melanotic lesions should be carefully followed up even if biopsy specimens repeatedly show no malignancy.

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“…125 This tumor usually appears as a hypoechoic mass or has mixed echogenicity at EUS in comparison with the healthy tissue of various esophageal layers. Several cases of primary malignant melanoma of the esophagus have been investigated in this way, 34,48,51,52,66,67,79 with postoperative pathologic assessments (pT, pN) usually in accordance with the predictions of EUS preoperative staging evaluations (uT, uN).…”

Section: Figurementioning

confidence: 99%

Primary Malignant Melanoma of the Esophagus

Bisceglia

Perri

Tucci

et al. 2011

Advances in Anatomic Pathology

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Primary malignant melanoma originating in the digestive tract is particularly rare, mainly affecting the anorectum and oral cavity. Primary malignant melanoma of the esophagus has been the subject mostly of case reports. This tumor has a dismal prognosis with a frequency estimated to be approximately 0.1% to 0.2% of all esophageal malignancies. According to the review by Volpin et al of November 2002, 238 cases of primary malignant melanoma of the esophagus have been published up to early 2001. We present an additional case of primary malignant melanoma of the esophagus of the amelanotic variant in a 69-year-old man. The patient was preoperatively investigated by esophageal endoscopy and endoscopic ultrasound. The surgically resected tumor specimen was examined histologically and supplemented by immunohistochemical and ultrastructural analysis. Intra-abdominal relapse occurred after 8 months at the site of surgery, necessitating repeat resection. The patient died of advanced intra-abdominal disease 14 months after the primary diagnosis. A comprehensive computerized (PubMed/Medline) review of the world literature was also carried out and 99 additional cases (after the review by Volpin et al) were found, 9 of them from the 1990s which escaped previous tabulations, and 90 from the years 2000 to 2010, amounting to a grand total of 337 ever published.

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Endoscopic Ultrasonography–Guided Fine Needle Aspiration Biopsy for Staging Malignant Melanoma of the Esophagus

Cited by 5 publications

References 18 publications

Clinical Cytology in the Diagnosis and Management of Melanoma

Clinical Cytology in the Diagnosis and Management of Melanoma

Primary Malignant Melanoma of the Esophagus Arising from a Melanotic Lesion: Report of a Case

Primary Malignant Melanoma of the Esophagus

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