Endoscopy in gastro-oesophageal reflux disease

Validation of the GerdQ questionnaire for the diagnosis of gastro‐oesophageal reflux disease

“…However, other reasons like anxiety for underlying malignancy, co‐morbidities and co‐medication will still be indications for diagnostic endoscopy. This approach will lead to a higher proportion of patients kept in primary care and a proper referral to secondary care for EGD/pH‐metry when symptoms persist despite treatment, with long symptom history, high age and the development of alarm features …”

“…In patients with endoscopy negative reflux disease (ENRD), oesophageal pH‐metry has moderate sensitivity and high specificity for the diagnosis of GERD . EGD and pH‐metry can be unpleasant to some patients, have limited availability in most healthcare systems and are resource demanding and costly . Symptom response to a short course of proton pump inhibitor (PPI) therapy is of questionable value as a diagnostic method for GERD …”

Gastroesophageal reflux in Bronchiectasis and the effect of anti-reflux treatment

“…Endoscopy provides evidence of esophagitis and HH [39], and the presence of HH is an important indication for laparoscopic treatment in our practice (Figure 2). 24-h Dual-channel esophageal pH monitoring, the standard test for GER, may demonstrate abnormal esophageal acid exposure in the absence of esophageal damage (i.e.…”

Randomised clinical trial: a comparison between a GerdQ‐based algorithm and an endoscopy‐based approach for the diagnosis and initial treatment of GERD

“…A high proportion of patients will eventually undergo OGD if reflux symptoms, irrespective of treatment or not, persist over time . Hence, an even longer time perspective will reduce the cost difference between the pathways.…”

“…Invasive investigations have traditionally been used to differentiate between erosive and non‐erosive GERD and to detect complications, but neither oesophagogastroduodenoscopy (OGD) nor 24‐h pH‐metry has the adequate sensitivity to be accepted as a diagnostic gold standard . The diagnosis is further hampered by poor correlation between symptom load and endoscopic findings . Even though reflux symptoms are strongly associated with the development of oesophageal adenocarcinoma the absolute risk of developing cancer is very low in the typical GERD patient who has no alarm features .…”