Validation of the GerdQ questionnaire for the diagnosis of gastro‐oesophageal reflux disease

Jonasson, Christian; Wernersson, Börje; Hoff, Dag Arne Lihaug; Hatlebakk, Jan Gunnar

doi:10.1111/apt.12204

Cited by 208 publications

(203 citation statements)

References 27 publications

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“…In our study, sensitivity and specificity compared with former clinical diagnosis was of 54% and 72%, respectively. More recently, Jonasson et al, 14 in the validation study for questionnaire in 169 patients with GERD (93% erosive) found higher sensitivity (78%) with lower specificity (50%). This difference can be explained since in this study, authors were highly biased by referrals and prevalence of erosive GERD.…”

Section: Discussionmentioning

confidence: 97%

Validation and Diagnostic Usefulness of Gastroesophageal Reflux Disease Questionnaire in a Primary Care Level in Mexico

Zavala-Gonzáles¹,

Azamar-Jácome²,

Meixueiro-Daza³

et al. 2014

J Neurogastroenterol Motil

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Background/Aims Different non-invasive diagnostics strategies have been used to assess patients with gastroesophageal reflux. Gastroesophageal reflux disease (GERD) questionnaire (GerdQ) is a 6-item, easy to use questionnaire that was developed primarily as a diagnostic tool for GERD in primary care. Our aim was to validate and assess diagnostic utility of GerdQ questionnaire in Mexican patients in the primary care setting. Methods The study was performed in 3 phases: (1) a questionnaire translation and comprehension study (n = 20), (2) are a reproducibility and validation study (50 patients and 50 controls) and (3) a study to assess the clinical utility in 252 subjects with GERD symptoms. Diagnostic accuracy was calculated using endoscopy and/or pH-metry as the gold standard. Results Internal consistency measured by the Cronbach’s α coefficient was 0.81 for patients and 0.90 for healthy controls, with a mixed coefficient of 0.93. Reproducibility for GerdQ was very good and its discriminating validity was 88%. Most of the patients with erosive reflux and non-erosive reflux with abnormal pH-metry had scores > 8, meanwhile most of the patients with functional heartburn and hypersensitive esophagus had < 8. Sensitivity, specificity and positive predictive value of GerdQ com -pared to the gold standard were 72%, 72% and 87%, respectively. Conclusions In Mexico, the GerdQ questionnaire Spanish validated version is useful for GERD diagnosis in the primary care setting.

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Section: Discussionmentioning

confidence: 97%

Validation and Diagnostic Usefulness of Gastroesophageal Reflux Disease Questionnaire in a Primary Care Level in Mexico

Zavala-Gonzáles¹,

Azamar-Jácome²,

Meixueiro-Daza³

et al. 2014

J Neurogastroenterol Motil

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“…Postprandial distress syndrome (PDS) was defined as the presence of symptoms with early satiation and/or postprandial fullness (present for last 3 months and onset at least 6 months prior to diagnosis). Reflux symptoms were evaluated with the gastroesophageal reflux disease questionnaires (GerdQ) [13,14]. The cut-off score of GerdQ was set at 8 as reported previously [14].…”

Section: Methodsmentioning

confidence: 99%

Gender Difference of Gastric Emptying in Healthy Volunteers and Patients with Functional Dyspepsia

Mori¹,

Suzuki

Matsuzaki³

et al. 2017

Digestion

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Background and Aim: Delayed gastric emptying is one of the reasons why functional dyspepsia (FD) occurs. The ¹³C-acetate breath test is widely used to evaluate gastric emptying. Nevertheless, the standard value of ¹³C-acetate breath test has not taken into account the gender difference of gastric emptying among healthy individuals. The main aim of this study was to readjust the standard value of ¹³C-acetate breath test in the light of gender differences. In addition, we clarified the prevalence and clinical characteristics of delayed gastric emptying in patients with FD using the modified standard values of ¹³C-acetate breath test. Methods: Fifty-two healthy individuals and 126 patients with patients with FD were enrolled. Gastric emptying was evaluated by the ¹³C-acetate breath test. The cut-off points of T_max for the diagnosis of delayed gastric emptying were determined on the basis of results from healthy individuals making a distinction of genders. Gastroesophageal reflux symptoms, dyspeptic symptoms, scores of anxiety and depression, age, body mass index (BMI), smoking and alcohol consumption were compared between the delayed gastric emptying group and the non-delayed gastric emptying group. Results: Since gastric emptying was delayed in healthy women compared with that in healthy men (T_max, 53.6 ± 19.3 vs. 42.7 ± 16.9 min, p = 0.04), we set the cut-off points of T_max at 60 min in men and at 75 min in women. In patients with FD, the prevalence of delayed gastric emptying was not different between men and women with the modified standard values of ¹³C-acetate breath test. (31.0 vs. 27.4%, p = 0.68). BMI was lower in the delayed gastric emptying group than in the non-delayed group among the male patients. Reflux symptoms were more severe in delayed gastric emptying group than in the non-delayed group among the female patients. Conclusion: The standard values of ¹³C-acetate breath test should be modified bearing the gender difference in mind. It provides us more appropriate information to understand the mechanisms of FD.

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“…Developed as an exploratory part of the DIAMOND study, this simple self administered 6-item questionnaire showed a fair diagnostic accuracy when compared to diagnosis of GERD made by EGD, pH-monitoring or response to PPI treatment if AET in pH-monitoring was borderline, with a sensitivity of 65%, specificity of 71% and positive predictive value (PPV) of 80% using a cut-off value of 8 or higher (range 0-18) (11,12). These results were reproduced in later studies (22). Two recent European multicentre prospective studies concluded that patient management based on GerdQ score was not only non-inferior in achieving patient satisfaction but also cheaper than a more classical strategy, based on prompter EGD and pH monitoring (13,14).…”

Section: Discussionmentioning

confidence: 69%

Sensitivity and specificity of the Gastrointestinal Short Form Questionnaire in diagnosis of gastroesophageal reflux disease

Sánchez-Vegazo¹,

Leal²,

García³

et al. 2016

Rev Esp Enferm Dig

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Introduction: Gastrointestinal Short Form Questionnaire (GSFQ) is a questionnaire for gastroesophageal reflux disease (GERD) diagnosis, with a version in Spanish language, not yet compared to an objective test.Aims: To establish GSFQ diagnostic performance against 24-hour pH monitoring carried out in two tertiary care hospitals.Methods: Consecutive adult patients with typical GERD symptoms (heartburn, regurgitation) referred for pH monitoring fulfilled the GSFQ (score range 0-30, proportional to probability of GERD). Diagnosis of GERD was established when acid exposure time in distal esophagus was superior to 4.5% or symptom association probability was greater than 95%. Receiver-operator characteristic (ROC) curves were calculated and best cut-off score determined, with corresponding sensitivity, specificity and likelihood ratios (LR) (95% confidence interval for each).Results: One hundred and fifty-two patients were included (59.9% women, age 47.9 ± 13.9; 97.4% heartburn; 71.3% regurgitation). pH monitoring was abnormal in 65.8%. Mean GSFQ score was 11.2 ± 6. Area under ROC was 56.5% (47.0-65.9%). Optimal cut-off score was 13 or greater: sensitivity 40% (30.3-50.3%), specificity 71.2% (56.9-82.9%), positive LR 1.39 (0.85-2.26) and negative LR 0.84 (0.67-1.07). Exclusion of questions 1 and 3 of the original GSFQ, easily interpreted as referred to dyspepsia and not GERD, improved only marginally the diagnostic performance: AUROC 59.1%. Conclusion:The GSFQ does not predict results of pH monitoring in patients with typical symptoms in a tertiary care setting.

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Validation of the GerdQ questionnaire for the diagnosis of gastro‐oesophageal reflux disease

Abstract: SUMMARY BackgroundThe diagnosis of gastro-oesophageal reflux disease (GERD) remains a challenge as both invasive methods and symptom-based strategies have limitations. The symptom-based management of GERD in primary care may be further optimised with the use of a questionnaire.

Cited by 208 publications

References 27 publications

Validation and Diagnostic Usefulness of Gastroesophageal Reflux Disease Questionnaire in a Primary Care Level in Mexico

Validation and Diagnostic Usefulness of Gastroesophageal Reflux Disease Questionnaire in a Primary Care Level in Mexico

Gender Difference of Gastric Emptying in Healthy Volunteers and Patients with Functional Dyspepsia

Sensitivity and specificity of the Gastrointestinal Short Form Questionnaire in diagnosis of gastroesophageal reflux disease

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