Endothelial cell activity varies in patients at risk for the adult respiratory distress syndrome

Moss, Marc; Gillespie, May K.; Ackerson, Lynn; Moore, F. A.; Moore, Ernest E.; Parsons, Polly E.

doi:10.1097/00003246-199611000-00004

Cited by 97 publications

(59 citation statements)

References 20 publications

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“…Hemodynamics, ventricular function, and oxygen delivery and consumption, however, are not different between sepsisrelated and non-sepsis-related ARDS. 23 Our study revealed no signifi cant difference between sepsisrelated and non-sepsis-related ARDS in baseline Pa o 2 /F io 2 ratio and severity of lung injury. However, patients with sepsis-related ARDS had lower serial Pao 2 /F io 2 ratios after ARDS diagnosis, indicating a poorer recovery from lung injury than patients with non-sepsis-related ARDS.…”

Section: Patients With Ards Excluded From Comparisonscontrasting

confidence: 48%

“…Studies measuring circulating biomarkers in patients with ARDS showed that protein C level was lower in patients with sepsis-related ARDS than in those with non-sepsis-related ARDS, whereas procalcitonin, neopterin, von Willebrand factor antigen, soluble intercellular adhesion molecule-1, and soluble E-selectin levels were higher. [23][24][25] Plasma cytokines also vary among clinical risk factors because interleukin-6, -8, and -10 levels are known to be higher in patients with ARDS caused by sepsis and pneumonia. 26 These factors together suggest a higher degree of acute infl ammation, endothelial cell activity, and coagulation activation in sepsis-related ARDS than in non-sepsis-related ARDS.…”

Section: Patients With Ards Excluded From Comparisonsmentioning

confidence: 99%

See 1 more Smart Citation

Clinical Characteristics and Outcomes of Sepsis-Related vs Non-Sepsis-Related ARDS

Sheu

Gong

Zhai³

et al. 2010

Chest

202

146

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A RDS, the more severe form of acute lung injury (ALI), is a common and lethal disease in ICUs worldwide. Clinically, ARDS is characterized by acute respiratory failure with severe hypoxemia and diffuse pulmonary infi ltrates. Despite recent advances in critical care and signifi cant efforts invested in the basic research and clinical trials of ARDS, its mortality rate (35%-45%) has remained relatively unchanged since 1994. 1 ARDS usually develops in patients with predisposing conditions that induce systemic infl ammatory response, such as sepsis, pneumonia, major trauma, multiple transfusions, aspiration, and acute pancreatitis, among which sepsis is the most common cause of ARDS. [2][3][4][5] In a large prospective cohort study, severe sepsis with a suspected pulmonary source (46%) or a nonpulmonary source (33%) was the most common risk factor for ALI. 6 On the other hand, only Background: ARDS may occur after either septic or nonseptic injuries. Sepsis is the major cause of ARDS, but little is known about the differences between sepsis-related and non-sepsis-related ARDS. Methods: A total of 2,786 patients with ARDS-predisposing conditions were enrolled consecutively into a prospective cohort, of which 736 patients developed ARDS. We defi ned sepsis-related ARDS as ARDS developing in patients with sepsis and non-sepsis-related ARDS as ARDS developing after nonseptic injuries, such as trauma, aspiration, and multiple transfusions. Patients with both septic and nonseptic risks were excluded from analysis. Results: Compared with patients with non-sepsis-related ARDS (n 5 62), patients with sepsisrelated ARDS (n 5 524) were more likely to be women and to have diabetes, less likely to have preceding surgery, and had longer pre-ICU hospital stays and higher APACHE III (Acute Physiology and Chronic Health Evaluation III) scores (median, 78 vs 65, P , .0001). There were no differences in lung injury score, blood pH, Pa O 2 /F IO 2 ratio, and Pa CO 2 on ARDS diagnosis. However, patients with sepsis-related ARDS had signifi cantly lower Pa O 2 /F IO 2 ratios than patients with nonsepsis-related ARDS patients on ARDS day 3 ( P 5 .018), day 7 ( P 5 .004), and day 14 ( P 5 .004) (repeated-measures analysis, P 5 .011). Compared with patients with non-sepsis-related ARDS, those with sepsis-related had a higher 60-day mortality (38.2% vs 22.6%; P 5 .016), a lower successful extubation rate (53.6% vs 72.6%; P 5 .005), and fewer ICU-free days ( P 5 .0001) and ventilatorfree days ( P 5 .003). In multivariate analysis, age, APACHE III score, liver cirrhosis, metastatic cancer, admission serum bilirubin and glucose levels, and treatment with activated protein C were independently associated with 60-day ARDS mortality. After adjustment, sepsis-related ARDS was no longer associated with higher 60-day mortality (hazard ratio, 1.26; 95% CI, 0.71-2.22). Conclusion: Sepsis-related ARDS has a higher overall disease severity, poorer recovery from lung injury, lower successful extubation rate, and higher mortality than non-sepsis-related ...

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Section: Patients With Ards Excluded From Comparisonscontrasting

confidence: 48%

Section: Patients With Ards Excluded From Comparisonsmentioning

confidence: 99%

Clinical Characteristics and Outcomes of Sepsis-Related vs Non-Sepsis-Related ARDS

Sheu

Gong

Zhai³

et al. 2010

Chest

202

146

View full text Add to dashboard Cite

show abstract

“…Sensitivity was 80% and specificity was 87% (McGill et al 1998). However, Moss et al (1996) could not verify these findings.…”

Section: Von Willebrand Factor and Adamts13mentioning

confidence: 84%

“…ARDS) or inflammation accompanied by infection as it occurs in sepsis. Nevertheless, vWF levels could help to differentiate between survivors and non-survivors in sepsis and high levels of vWF were correlated to fewer days organ-failure-free days (Moss et al 1996;Scherpereel et al 2006). Furthermore, plasma vWF-antigen levels were associated with the development of acute lung injury and 28-day survival.…”

Section: Von Willebrand Factor and Adamts13mentioning

confidence: 99%

Biomarkers of endothelial dysfunction: can they help us deciphering systemic inflammation and sepsis?

2011

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“…Additionally, there is an existing increase in other biomarkers of this category like cellular and soluble endothelial leukocyte adhesion molecule (ELAM)-1 and vascular endothelial growth factor (VEGF) in septic patients with very poor prognosis, but further clinical studies must be demonstrated. (Drake et al 1993, Mimuro et al 2008, Seidelin et al 2002, Whalen et al 2000, Cowley et al, 1994, Moss et al, 1996.…”

Section: Vascular and Endothelial Damage Dysfunction Biomarkersmentioning

confidence: 99%

Biomarkers and Physiological Agents in Severe Sepsis and Septic Shock

Paramythiotis¹,

Digkas²,

Dryllis³

2012

Severe Sepsis and Septic Shock - Understanding a Serious Killer

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Endothelial cell activity varies in patients at risk for the adult respiratory distress syndrome

Abstract: These findings suggest that differences in endothelial cell activity exist between sepsis and trauma patients who are at risk for the development of ARDS.

Cited by 97 publications

References 20 publications

Clinical Characteristics and Outcomes of Sepsis-Related vs Non-Sepsis-Related ARDS

Clinical Characteristics and Outcomes of Sepsis-Related vs Non-Sepsis-Related ARDS

Biomarkers of endothelial dysfunction: can they help us deciphering systemic inflammation and sepsis?

Biomarkers and Physiological Agents in Severe Sepsis and Septic Shock

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