Endothelial cells regulated by RNF20 orchestrate the proliferation and differentiation of neural precursor cells during embryonic development

Zhang, Mengtian; Su, Lihe; Wang, Wenwen; Li, Chenxiao; Liang, Qingli; Ji, Fen; Jiao, Jianwei

doi:10.1016/j.celrep.2022.111350

Cited by 11 publications

(4 citation statements)

References 56 publications

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“…Ring finger protein 20 (Rnf20) is an E3 ubiquitin ligase that is widely involved in transcriptional regulation, DNA damage response, stem cell differentiation, and lipid metabolism. [56][57][58] Highly expressed in astrocytes, Rnf20 regulates the expression of STAT3 by mediating H2Bub1, thereby controlling the generation of neural progenitor astrocytes, 33 endothelial RNF20-deficient mice show autistic behavior, 59 while its overexpression in the dorsal horn induces pain hypersensitivity. 60 Other members of the Rnf family have been similarly implicated in neurodegenerative diseases.…”

Section: Discussionmentioning

confidence: 99%

“… 56 , 57 , 58 Highly expressed in astrocytes, Rnf20 regulates the expression of STAT3 by mediating H2Bub1, thereby controlling the generation of neural progenitor astrocytes, 33 which plays a crucial role in brain complexity, plasticity, and cognition. Moreover, studies have demonstrated that endothelial RNF20‐deficient mice show autistic behavior, 59 while its overexpression in the dorsal horn induces pain hypersensitivity. 60 Other members of the Rnf family have been similarly implicated in neurodegenerative diseases.…”

Section: Discussionmentioning

confidence: 99%

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Systems genetics analysis reveals the common genetic basis for pain sensitivity and cognitive function

Xu,

Chen,

Pan

et al. 2024

CNS Neurosci Ther

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BackgroundThere is growing evidence of a strong correlation between pain sensitivity and cognitive function under both physiological and pathological conditions. However, the detailed mechanisms remain largely unknown. In the current study, we sought to explore candidate genes and common molecular mechanisms underlying pain sensitivity and cognitive function with a transcriptome‐wide association study using recombinant inbred mice from the BXD family.MethodsThe pain sensitivity determined by Hargreaves' paw withdrawal test and cognition‐related phenotypes were systematically analyzed in 60 strains of BXD mice and correlated with hippocampus transcriptomes, followed by quantitative trait locus (QTL) mapping and systems genetics analysis.ResultsThe pain sensitivity showed significant variability across the BXD strains and co‐varies with cognitive traits. Pain sensitivity correlated hippocampual genes showed a significant involvement in cognition‐related pathways, including glutamatergic synapse, and PI3K‐Akt signaling pathway. Moreover, QTL mapping identified a genomic region on chromosome 4, potentially regulating the variation of pain sensitivity. Integrative analysis of expression QTL mapping, correlation analysis, and Bayesian network modeling identified Ring finger protein 20 (Rnf20) as the best candidate. Further pathway analysis indicated that Rnf20 may regulate the expression of pain sensitivity and cognitive function through the PI3K‐Akt signaling pathway, particularly through interactions with genes Ppp2r2b, Ppp2r5c, Col9a3, Met, Rps6, Tnc, and Kras.ConclusionsOur study demonstrated that pain sensitivity is associated with genetic background and Rnf20‐mediated PI3K‐Akt signaling may involve in the regulation of pain sensitivity and cognitive functions.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Systems genetics analysis reveals the common genetic basis for pain sensitivity and cognitive function

Xu,

Chen,

Pan

et al. 2024

CNS Neurosci Ther

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“…As mentioned previously, osteoblasts derived Slit3 is associated with type H vessels remodeling. 21 Though it has been reported that blood vessels could control neural growth in brain tissue, [45][46][47] the evidence of type H vessels in regulating neural growth during bone regeneration remains unknown, which may need to be further studied. In future, the specific mechanism mutual regulation between the nervous system regulates and type H blood vessels remains to be further studied.…”

Section: The Role Of Blood Flow In Coupling Angiogenesis and Osteogen...mentioning

confidence: 99%

Type H blood vessels in coupling angiogenesis‐osteogenesis and its application in bone tissue engineering

Kusumbe

Cai

et al. 2023

J Biomed Mater Res

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One specific capillary subtype, termed type H vessel, has been found with unique functional characteristics in coupling angiogenesis with osteogenesis. Researchers have fabricated a variety of tissue engineering scaffolds to enhance bone healing and regeneration through the accumulation of type H vessels. However, only a limited number of reviews discussed the tissue engineering strategies for type H vessel regulation. The object of this review is to summary the current utilizes of bone tissue engineering to regulate type H vessels through various signal pathways including Notch, PDGF-BB, Slit3, HIF-1α, and VEGF signaling. Moreover, we give an insightful overview of recent research progress about the morphological, spatial and agedependent characteristics of type H blood vessels. Their unique role in tying angiogenesis and osteogenesis together via blood flow, cellular microenvironment, immune system and nervous system are also summarized. This review article would provide an insight into the combination of tissue engineering scaffolds with type H vessels and identify future perspectives for vasculized tissue engineering research.

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“…Meanwhile, collecting duct (CD) cells specialize in water reabsorption and contribute significantly to maintaining osmotic pressure and overall homeostasis [9]. Given these factors, it is expected that lipid accumulation within renal tissues due to a high-fat diet and abnormal lipid metabolism The ring finger protein 20 (RNF20), a transcriptional regulator and E3-ubiquitin ligase known for its multifaceted roles in DNA damage response [10], stem cell differentiation [11], and lipid biosynthesis [12], was investigated in this study. RNF20-induced SREBP1c ubiquitination downregulates hepatic lipogenic activity and reduces renal cancer metastasis [13].…”

Section: Introductionmentioning

confidence: 99%

Impact of Ring Finger Protein 20 and Its Downstream Regulation on Renal Tubular Injury in a Unilateral Nephrectomy Mouse Model Fed a High-Fat Diet

Kim,

Oh,

Lim

et al. 2023

Nutrients

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Abnormal lipid metabolism increases the relative risk of kidney disease in patients with a single kidney. Using transcriptome analysis, we investigated whether a high-fat diet leads to abnormalities in lipid metabolism and induces kidney cell-specific damage in unilateral nephrectomy mice. Mice with unilateral nephrectomy fed a high-fat diet for 12 weeks exhibited progressive renal dysfunction in proximal tubules, including lipid accumulation, vacuolization, and cell damage. Ring finger protein 20 (RNF20) is a ligase of nuclear receptor corepressor of peroxisome proliferator-activated receptors (PPARs). The transcriptome analysis revealed the involvement of RNF20-related transcriptome changes in PPAR signaling, lipid metabolism, and water transmembrane transporter under a high-fat diet and unilateral nephrectomy. In vitro treatment of proximal tubular cells with palmitic acid induced lipotoxicity by altering RNF20, PPARα, and ATP-binding cassette subfamily A member 1 (ABCA1) expression. PPARγ and aquaporin 2 (AQP2) expression decreased in collecting duct cells, regulating genetic changes in the water reabsorption process. In conclusion, a high-fat diet induces lipid accumulation under unilateral nephrectomy via altering RNF20-mediated regulation and causing functional damage to cells as a result of abnormal lipid metabolism, thereby leading to structural and functional kidney deterioration.

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Endothelial cells regulated by RNF20 orchestrate the proliferation and differentiation of neural precursor cells during embryonic development

Cited by 11 publications

References 56 publications

Systems genetics analysis reveals the common genetic basis for pain sensitivity and cognitive function

Systems genetics analysis reveals the common genetic basis for pain sensitivity and cognitive function

Type H blood vessels in coupling angiogenesis‐osteogenesis and its application in bone tissue engineering

Impact of Ring Finger Protein 20 and Its Downstream Regulation on Renal Tubular Injury in a Unilateral Nephrectomy Mouse Model Fed a High-Fat Diet

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