ENDOTHELIAL DYSFUNCTION AS A PART OF COVID-19’S PATHOGENESIS (literature review)

Simutis, I. S.; Николаева, Ольга Викторовна; Salygina, D.S.; Danilov, M. S.; Korotaev, A. S.; Semigolovskii, N. Yu.

doi:10.56547/22263071_2022_3_39

Cited by 1 publication

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“…The addition of a secondary bacterial infection contributes to the further progression of processes and the development of pneumonia favors polymorbid bacterial inflammation [17,20]. With the relief of pathological changes in the lungs, the risk of a serious complication in the form of organized pulmonary fibrosis remains [21,22]. Thus, in the pathogenesis of a new coronavirus infection, the most prognostically significant phase is hyperinflammation ("cytokine storm"), when massive tissue damage occurs, often in combination with gram-negative infection.…”

Section: Medical Sciencesmentioning

confidence: 99%

Medical and Social Aspects of the New Coronavirus Infection

Abdimomunova¹,

Zholdoshev²

2023

EJNH

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The article presents the data of an analytical review of a new coronavirus infection at the present stage of the development of healthcare in the Kyrgyz Republic, actualizes the issues of quality of specialized medical care to the population, especially in the context of a pandemic and epidemic. The presented review article highlights current data related to issues of etiology, pathogenesis, clinical characteristics, as well as problems of sarcopenia, a condition characterized by loss of muscle mass, decreased strength, and epidemic characteristics of a new coranovirus infection. The etiology, morbidity, risk factors are considered, new possibilities of specific prevention of this infection are studied. The analysis of statistical results of indicators characterizing the epidemiological picture of COVID-19, including the dynamics of morbidity in the territory of the Kyrgyz Republic for the period 2020-2022 was carried out. Comprehensive studies in this aspect: providing consultative and diagnostic assistance to the population, as well as medical and social significance of the identification and early diagnosis of a new COVID-19 coronavirus infection from the beginning of the pandemic to the present. The availability of information on the mechanisms of the emergence of new viruses is considered, the clinical and epidemiological features of outbreaks of coronavirus infections are studied, the identification of factors contributing to the spread of infections has made it possible to identify the most significant measures to prevent the spread of dangerous infections. Carrying out anti-epidemic, including isolation-restrictive and disinfection measures, informing the population about ways to protect against infection, etc. -these measures are widely used in the world in the fight against epidemics. The COVID-19 epidemic has gone down in history as an emergency of international importance. Currently, there are practically no effective treatments so far. Cosmic changes in the lifestyle of people in the XXI century have already negatively affected the state of psychosomatic health of the population. The current COVID-19 pandemic has played the role of a trigger factor in the development of psychosocial stress with a sharp increase in somatic problems. The feeling of fear and uncertainty from the virus threat at the beginning of 2019-2022 was replaced by the threat of social ill-being due to political and economic changes. How to minimize and prevent the negative effects of stress, how not to miss alarm signals, what treatment to prescribe remain relevant and important for practical application information is presented in this article.

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Section: Medical Sciencesmentioning

confidence: 99%