A retrospective analysis of clinical and immunological manifestations of COVID-19 was performed in 419 patients (women n=167 (39.8 %) men n= 252 (60.2 %)) aged 20 to 80 years. Mild stage I (early infection) in patients was mainly manifested by symptoms characteristic of other acute respiratory infections. Distinctive features were the loss (distortion) of smell and taste. The clinical manifestations of stage II (pulmonary) were determined by lung damage in the form of pneumonitis. Stage III (hyperinflammatory response) it was characterized by severe lung damage, involvement of other organs in the pathological process as a consequence of a hyperimmune reaction. The determination of cellular and humoral immunity indicators reflected the severity of damage to the body's immune system, and, accordingly, the severity of the course of coronavirus infection. The variety of clinical manifestations and examination results confirms that COVID-19 is a systemic disease with a multi-organ lesion that requires in-depth study of its clinical and immunological features.

The coronavirus pandemic has caused massive economic, social and moral damage to humanity. Repeated waves of morbidity three years after the start of the COVID-19 pandemic require a comprehensive analysis of the epidemic situation and the problems of organizing and conducting preventive and anti-epidemic measures. A retrospective analysis of the incidence of COVID-19 and community-acquired pneumonia in the Jalal-Abad region of the Kyrgyz Republic in 2020 and 2021 was carried out. The frequency of detection of virus genetic material in nasopharyngeal smears was studied. An assessment of the coverage of vaccinations against COVID-19 and the proportion of people who sought medical care in day hospitals was carried out. It was found that several factors contributed to the decrease in the incidence of COVID-19 at once — the variability of pathogens, an increase in the proportion of the population ith specific protection, and the implementation of demarcation measures. A distinctive feature of the Jalal-Abad region was the deployment of day hospitals operating on the principle of the «red zone». This made it possible to increase the coverage of the population with medical care and prevent the further spread of the pathogen. The ongoing pandemic requires additional research and adjustment of countermeasures when new factors and circumstances are identified.

The article presents static analysis data on vaccination among residents of Dzhalal-Abad region from the beginning of the pandemic to the present. The availability of different types of vaccines is considered based on the result of provision at the expense of states, as well as the prospects for expanding vaccines to ensure the required volume of vaccination. Effective results of mass vaccinations were revealed in the formation of herd immunity, which prevented the occurrence of repeated outbreaks of the disease. The data of the analysis carried out over 2 years indicate that the position of health workers is consistent with the ways to solve the quarantine of the entire population of Dzhalal-Abad region. In 2021, the month of the peak of the incidence, the number of opponents of vaccination decreased from 29% to 23%. The number of people who are not going to be vaccinated has sharply decreased, but the number of actually vaccinated has increased slightly.

The article reflects the results of studies on the incidence of COVID-19 and community-acquired pneumonia in the Suzak district of Jalal-Abad region during the pandemic of 2020. As a result of the analysis of morbidity, it was shown that the beginning of the incidence of COVID-19 occurred in March 2020, and the beginning of community-acquired pneumonia — in June 2020. The study conducted by the co-authors confirmed that the month of July is the peak of morbidity, and then the highest incidence of COVID-19 and out-of-hospital pneumonia was registered in the autumn period: October-November. According to the results of studies conducted during the global outbreak, it was revealed that the greatest affected age is from 30 to 64 years, 65 years in second place. According to the results of the gender of those who underwent COVID-19, higher rates were women than men. The assessment of prevalence by social groups showed a higher proportion of morbidity among the unemployed population, among the retirement age and medical workers. In the district, out of the number of medical workers who fell ill with COVID-19, the confirmed case was 10.7%, community-acquired pneumonia — 7.9%. According to the epidemiological history, more likely foci of infection and sources of infections have been identified. During the pandemic, in order to prevent coronavirus infection and provide medical care to the population, isolation wards with 295 beds were organized. During the period of operation of the isolators, a total of 1,674 patients were treated. There were also 160 places for observation, where 543 people were under medical supervision. 4 mobile teams were organized, which visited 921 foci and 2721 PCR tests were taken from contact persons. To organize medical care for patients with community-acquired pneumonia during the pandemic in the district, from July, August and October, 5 day hospitals were organized, with 332 beds. The provision of beds per 10 thousand population was 11.3%.

The article presents the data of an analytical review of a new coronavirus infection at the present stage of the development of healthcare in the Kyrgyz Republic, actualizes the issues of quality of specialized medical care to the population, especially in the context of a pandemic and epidemic. The presented review article highlights current data related to issues of etiology, pathogenesis, clinical characteristics, as well as problems of sarcopenia, a condition characterized by loss of muscle mass, decreased strength, and epidemic characteristics of a new coranovirus infection. The etiology, morbidity, risk factors are considered, new possibilities of specific prevention of this infection are studied. The analysis of statistical results of indicators characterizing the epidemiological picture of COVID-19, including the dynamics of morbidity in the territory of the Kyrgyz Republic for the period 2020-2022 was carried out. Comprehensive studies in this aspect: providing consultative and diagnostic assistance to the population, as well as medical and social significance of the identification and early diagnosis of a new COVID-19 coronavirus infection from the beginning of the pandemic to the present. The availability of information on the mechanisms of the emergence of new viruses is considered, the clinical and epidemiological features of outbreaks of coronavirus infections are studied, the identification of factors contributing to the spread of infections has made it possible to identify the most significant measures to prevent the spread of dangerous infections. Carrying out anti-epidemic, including isolation-restrictive and disinfection measures, informing the population about ways to protect against infection, etc. -these measures are widely used in the world in the fight against epidemics. The COVID-19 epidemic has gone down in history as an emergency of international importance. Currently, there are practically no effective treatments so far. Cosmic changes in the lifestyle of people in the XXI century have already negatively affected the state of psychosomatic health of the population. The current COVID-19 pandemic has played the role of a trigger factor in the development of psychosocial stress with a sharp increase in somatic problems. The feeling of fear and uncertainty from the virus threat at the beginning of 2019-2022 was replaced by the threat of social ill-being due to political and economic changes. How to minimize and prevent the negative effects of stress, how not to miss alarm signals, what treatment to prescribe remain relevant and important for practical application information is presented in this article.