The coronavirus pandemic has caused massive economic, social and moral damage to humanity. Repeated waves of morbidity three years after the start of the COVID-19 pandemic require a comprehensive analysis of the epidemic situation and the problems of organizing and conducting preventive and anti-epidemic measures. A retrospective analysis of the incidence of COVID-19 and community-acquired pneumonia in the Jalal-Abad region of the Kyrgyz Republic in 2020 and 2021 was carried out. The frequency of detection of virus genetic material in nasopharyngeal smears was studied. An assessment of the coverage of vaccinations against COVID-19 and the proportion of people who sought medical care in day hospitals was carried out. It was found that several factors contributed to the decrease in the incidence of COVID-19 at once — the variability of pathogens, an increase in the proportion of the population ith specific protection, and the implementation of demarcation measures. A distinctive feature of the Jalal-Abad region was the deployment of day hospitals operating on the principle of the «red zone». This made it possible to increase the coverage of the population with medical care and prevent the further spread of the pathogen. The ongoing pandemic requires additional research and adjustment of countermeasures when new factors and circumstances are identified.

The article presents static analysis data on vaccination among residents of Dzhalal-Abad region from the beginning of the pandemic to the present. The availability of different types of vaccines is considered based on the result of provision at the expense of states, as well as the prospects for expanding vaccines to ensure the required volume of vaccination. Effective results of mass vaccinations were revealed in the formation of herd immunity, which prevented the occurrence of repeated outbreaks of the disease. The data of the analysis carried out over 2 years indicate that the position of health workers is consistent with the ways to solve the quarantine of the entire population of Dzhalal-Abad region. In 2021, the month of the peak of the incidence, the number of opponents of vaccination decreased from 29% to 23%. The number of people who are not going to be vaccinated has sharply decreased, but the number of actually vaccinated has increased slightly.

The strategic objective of healthcare is to ensure the quality of medical care and create a safe environment for patients and staff in organizations engaged in medical activities. Infections associated with the provision of medical care are the most important component of this problem due to the widespread negative consequences for the health of patients, staff and the economy of the state. Currently, the problem of prevention and control of infections associated with the provision of medical care remains relevant, because reflects the quality of medical care provided to the population and causes significant economic damage to the country’s healthcare. Infections associated with the provision of medical care is a term for a group of infections, which displays a modern understanding of hospital-acquired infections in accordance with international approaches. The general criterion for classifying infections as infections related to medical care is that their occurrence is associated with the provision of medical care (treatment, diagnosis, prevention, etc.). The largest number of healthcare-associated infections in Kyrgyzstan is registered annually in maternity hospitals and accounts for 33.0% of all cases of this group of infections. As before, the risk of infection with hospital strains of microorganisms remains high in the departments of newborns and premature infants, intensive care units and intensive care units, and according to official statistics, the frequency of healthcare-associated infections in newborns is 16.8%. According to selective studies, the true incidence of infections associated with medical care in maternity institutions is several times higher than the officially registered one, cases of concealing cases of morbidity among newborns and maternity hospitals are not uncommon.

In order to identify the epidemiological features of the incidence of COVID-19 in the Jalal-Abad region of the Kyrgyz Republic, a retrospective epidemiological analysis was carried out, according to the results of which the following was established. Jalal-Abad region was the leader in the number of cases of new coronavirus infection in the Kyrgyz Republic in 2020. The incidence had a pronounced rise with a maximum in October. The most disadvantaged in this period in terms of the incidence of a new coronavirus infection were Mailuu-SUU (1663.2 per 100 thousand), Chatkal (1000.8 per 100 thousand), Jalal-Abad (677.6 per 100 thousand) and Kara-Kol (532.0 per 100 thousand). In all territorial entities of the region, cases of COVID-19 were registered mainly among the adult population. The diseases of the new coronavirus infection in children were isolated. The greatest proportion of cases occurred in people aged 30–64 years, which is due to the larger number of this group, as well as the most severe course of the disease. Most often, the diseases occurred in the form of moderate severity (47.2 %) and mild (22.7 %). At the same time, according to the results of laboratory studies, it was possible to identify 14.9 % of cases of the disease with an asymptomatic course. The condition was regarded as severe in 12.2 % of cases, extremely severe — in 3 %. High focality was revealed. The share of foci with two cases was 63.2 %, with three — 19.3 %, four — 6.2 %, five — 5.5 %, six or more — 5.8 %. Most foci with four or more cases were registered in Ala-Buka, Suzak, Toktogul, Nooken districts and the city of Tash-Komur. The study made it possible to identify the features of the course of the epidemic process of a new coronavirus infection, which made it possible to adjust the implementation of preventive and anti-epidemic measures in the future, to reduce the rate of focality, to minimize mortality. At the same time, the main role in the prevention of COVID-19 from the moment of registration of vaccines against this infection is assigned to specific prevention.