Endothelial dysfunction in Buerger's disease and its relation to markers of inflammation

Abstract

Our study has expressed generalized functional arterial disorder in patients with BD not accompanied by any measurable morphological changes of the carotid arterial wall. Functional deterioration of brachial artery could be related to increased levels of various inflammatory markers--the process which is most probably the basic pathogenetic mechanism of the disease.

Flow-mediated vasodilation is augmented in a corkscrew collateral artery compared with that in a native artery in patients with thromboangiitis obliterans (Buerger disease)

“…27,28 In the present study also, FMD in native leg arteries in patients with Buerger disease was impaired compared with that in healthy subjects. The precise mechanism of endothelial dysfunction in patients with Buerger disease is unclear.…”

“…Buerger disease is also associated with endothelial dysfunction. 27,28 However, there is no information on vascular function in native leg arteries and corkscrew collateral arteries per se in patients with Buerger disease. Therefore, we assessed vascular function in a leg artery using ultrasonography in patients with Buerger disease and age-and sex-matched healthy subjects.…”

Thromboangiitis obliterans and endothelial function

“…The power of our study is likely to be too low to detect differences in some of the outcome variables, as a result of the relatively small subject numbers, even though these numbers are within a similar range to those reported by Joras et al. [8].…”

Urocortin promotes the development of vasculitis in a rat model of thromboangiitis obliterans via corticotrophin‐releasing factor type 1 receptors

“…Clinical reports indicate that ICAM‐1 expression is elevated in TAO patients (Halacheva et al. , 2002; Joras et al. , 2006) and treatment with COX‐2 inhibitors can relieve the disease condition (Nizankowski et al.…”