Endothelial function after ST-elevation myocardial infarction in patients with high levels of high-sensitivity CRP and Lp-PLA 2 : A substudy of the RESPONSE randomized trial

Kandhai-Ragunath, Jasveen J.; Wagenaar, Bjorn de; Doelman, C. J. A.; Es, Jan van; Jørstad, Harald T; Peters, Ron J.G.; Doggen, Carine J.M.; Birgelen, Clemens von

doi:10.1016/j.carrev.2016.12.019

Cited by 2 publications

(2 citation statements)

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“…Lp‐PLA2 is reported to be involved in the development of atherosclerosis 16–18 . The elevated serum Lp‐PLA2 level of the patients with STEMI in our study is in accordance with the previous reports 25,26 . Stankovic et al 21 .…”

Section: Discussionsupporting

confidence: 92%

The Relationship Between the Level of Serum ESM‐1 and Lp‐PLA2 in Patients With Acute ST‐Segment Elevation Myocardial Infarction

Wei

Zong

Liu

et al. 2020

Clinical Translational Sci

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Acute ST‐segment elevation myocardial infarction (STEMI) is the most lethal coronary heart disease with vascular endothelium dysfunction and inflammation in the disease development process. Endothelial cell‐specific molecule 1 (ESM‐1) and lipoprotein‐associated phospholipase A2 (Lp‐PLA2) are important for the diagnosis and characterization of STEMI. To date, no studies have reported the correlation between ESM‐1 and Lp‐PLA2 levels in patients with STEMI, which may be an important predictor of the fatal disease. To measure the level of serum ESM‐1 and Lp‐PLA2, and to evaluate the relationship and the clinical significance of these two biomarkers in patients with acute STEMI, 37 inpatients with acute STEMI were sequentially enrolled in the research group and 24 study objects with normal coronary artery function were included in the control group. The measurement of the relative parameters was done by enzyme‐linked immunosorbent assay using blood samples taken from the median cubital vein while the inpatients were enrolled. The levels of serum SEM‐1 and Lp‐PLA2 were significantly higher in patients with acute STEMI than in study objects with normal coronary artery function ( P < 0.05). A significant correlation of serum SEM‐1 and Lp‐PLA2 was observed, leading to close linearity ( r 2 = 0.8131, P < 0.0001). In conclusion, the endothelium dysfunction factor ESM‐1 and inflammatory factor Lp‐PLA2 are significantly higher and correlated in patients with acute STEMI. These two factors could be novel and effective biomarkers for acute STEMI diagnosis and evaluation.

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Section: Discussionsupporting

confidence: 92%

The Relationship Between the Level of Serum ESM‐1 and Lp‐PLA2 in Patients With Acute ST‐Segment Elevation Myocardial Infarction

Wei

Zong

Liu

et al. 2020

Clinical Translational Sci

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“…При исследовании функции эндотелия в настоящей работе мы подтвердили показанную ранее нами и другими исследователями дисфункцию эндотелия у пациентов с ОИМ [21,31,38,76,77]. Ранее было выявлено, что наравне с такими ФР, как гиперлипидемия, курение, СД и АГ, ЭЗВД является независимым предиктором развития сердечно-сосудистых осложнений [78][79][80].…”

Section: показательunclassified

Cytomegalovirus Infection and Endothelial Function in Patients With Acute Myocardial Infarction

Lebedeva

Mariukhnich

Grievel

et al. 2018

CARDIO

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Endothelial function after ST-elevation myocardial infarction in patients with high levels of high-sensitivity CRP and Lp-PLA 2 : A substudy of the RESPONSE randomized trial

Cited by 2 publications

References 30 publications

The Relationship Between the Level of Serum ESM‐1 and Lp‐PLA2 in Patients With Acute ST‐Segment Elevation Myocardial Infarction

The Relationship Between the Level of Serum ESM‐1 and Lp‐PLA2 in Patients With Acute ST‐Segment Elevation Myocardial Infarction

Cytomegalovirus Infection and Endothelial Function in Patients With Acute Myocardial Infarction

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