Endothelial Function and Carotid Intima-Medial Thickness in Adolescents with Type 2 Diabetes Mellitus

Naylor, Louise H.; Green, Daniel; Jones, Timothy W.; Kalic, Rachelle J.; Suriano, Katie; Shah, Mark; Hopkins, Nicola; Davis, Elizabeth A.

doi:10.1016/j.jpeds.2011.05.019

Cited by 41 publications

(39 citation statements)

References 21 publications

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“…[93][94][95][96][97] Factors associated with this higher cIMT include lower vitamin C levels 98 and longer duration of disease. 99,100 Adolescents with T2DM also demonstrate higher cIMT compared with healthy control subjects, 101,102 with diabetes mellitus duration 103 and glucose control playing a role. 104 Factors affecting the progression of cIMT in adolescents and young adults with diabetes mellitus include the number of receptors for advanced glycation end products, 105 HbA 1c , 106 and diabetes mellitus duration.…”

mentioning

confidence: 98%

“…Poor endothelial function was associated with higher HbA 1c 121 and poor fitness level 122 but was not related to inflammation. 123 Endothelial dysfunction has also been found in youth with T2DM when measured by flow-mediated dilation 101 venous plethysmography. 124 Interventions including exercise 125 and intensive glucose control 126 improved endothelial function in young patients with T1DM.…”

mentioning

confidence: 99%

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Cardiovascular Disease Risk Factors in Youth With Diabetes Mellitus

Maahs¹,

Daniels²,

Ferranti³

et al. 2014

Circulation

162

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mentioning

confidence: 98%

mentioning

confidence: 99%

Cardiovascular Disease Risk Factors in Youth With Diabetes Mellitus

Maahs¹,

Daniels²,

Ferranti³

et al. 2014

Circulation

162

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“…Youth with T2D and with obesity were found to have elevated a-PWV compared with normal weight controls [43,44]. Youth with T2D had higher carotid IMT compared with lean and obese normoglycemic controls [45,46]. In our studies of well-characterized obese youth with and without T2D, we found a significant association between carotid IMT and glycemia, as reflected by HbA1c, whereas vascular stiffness (a-PWV) was mainly related to insulin resistance and inflammation [47••].…”

Section: Vascular Health In Youth With Obesity and T2dmmentioning

confidence: 87%

Cardiac Abnormalities in Youth with Obesity and Type 2 Diabetes

Bacha

Gidding

2016

Curr Diab Rep

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Childhood obesity has been linked to cardiovascular disease (CVD) risk in adulthood. Of great concern is the expected increase in the population's CVD burden in relation to childhood obesity. This is compounded by the risk related to chronic hyperglycemia exposure in youth with type 2 diabetes. We herein provide an overview of the spectrum of early cardiovascular disease manifestation in youth with obesity and type 2 diabetes, in particular abnormalities in cardiac structure and function. Cardiac remodeling and adverse target organ damage is already evident in the pediatric age group in children with obesity and type 2 diabetes. This supports the importance of intensifying obesity prevention efforts and early intervention to treat comorbidities of obesity in the pediatric age group to prevent cardiac events in early adulthood.

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“…Although we found 2 articles describing the absence of endothelial dysfunction in obese children [21,107], numerous research groups have reported on impaired endothelialdependent vasodilation, assessed with FMD, in this population [108][109][110][111][112][113][114][115][116][117][118][119][120][121][122].…”

Section: Flow-mediated Dilationmentioning

confidence: 99%

National Trends in Beverage Consumption in Children from Birth to 5 Years: Analysis of NHANES Across Three Decades

2013

Childhood Obesity

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The association of obesity with noncommunicable diseases, such as cardiovascular complications and diabetes, is considered a major threat to the management of health care worldwide. Epidemiological findings show that childhood obesity is rapidly rising in Western society, as well as in developing countries. This pandemic is not without consequences and can affect the risk of future cardiovascular disease in these children. Childhood obesity is associated with endothelial dysfunction, the first yet still reversible step towards atherosclerosis. Advanced research techniques have added further insight on how childhood obesity and associated comorbidities lead to endothelial dysfunction. Techniques used to measure endothelial function were further brought to perfection, and novel biomarkers, including endothelial progenitor cells, were discovered. The aim of this paper is to provide a critical overview on both in vivo as well as in vitro markers for endothelial integrity. Additionally, an in-depth description of the mechanisms that disrupt the delicate balance between endothelial damage and repair will be given. Finally, the effects of lifestyle interventions and pharmacotherapy on endothelial dysfunction will be reviewed.

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Endothelial Function and Carotid Intima-Medial Thickness in Adolescents with Type 2 Diabetes Mellitus

Cited by 41 publications

References 21 publications

Cardiovascular Disease Risk Factors in Youth With Diabetes Mellitus

Cardiovascular Disease Risk Factors in Youth With Diabetes Mellitus

Cardiac Abnormalities in Youth with Obesity and Type 2 Diabetes

National Trends in Beverage Consumption in Children from Birth to 5 Years: Analysis of NHANES Across Three Decades

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