Endothelial function and its relationship to leptin, homocysteine, and insulin resistance in lean and overweight eumenorrheic women and PCOS patients: a pilot study

Mancini, Fulvia; Cianciosi, Arianna; Marchesini, Giulio; Facchinetti, Fabio; Battaglia, Cesare; Aloysio, Domenico De

doi:10.1016/j.fertnstert.2008.03.023

Cited by 41 publications

(27 citation statements)

References 36 publications

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“…We have also found that HOMA-IR is positively correlated with leptin but this correlation was not significant (r = 0.148, p = 0.258). Our results are similar to study conducted by Mancini et al [12] and Erturk et al [13] who reported no significant correlation between leptin and HOMA-IR (r = 0.317, p value [ 0.5). Recent studies have shed some light on the possible relationship of insulin with leptin levels.…”

Section: Discussionsupporting

confidence: 92%

Study of Association of Leptin and Insulin Resistance Markers in Patients of PCOS

et al. 2015

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Polycystic ovary syndrome (PCOS) is a common endocrinological disorder among women of the reproductive age group with long term sequelae which include diabetes mellitus, hypertension and CAD. The present study was conducted to evaluate the association of leptin-an adipokine playing an important role in carbohydrate metabolism and markers of insulin resistance among women with PCOS. Sixty diagnosed cases of PCOS as per Rotterdam criteria were enrolled in this study after informed written consent. Insulin resistance was estimated using the homeostatic model assessment-insulin resistance (HOMA-IR). HOMA-IR was calculated as the product of the fasting plasma insulin value (mU/ml) and the fasting plasma glucose value (mg/dl), divided by 405 and HOMA b was calculated as 360 9 [insulin]/([glucose] -63) % (glucose in mg/dl). Estimation of serum leptin levels was done by ELISA using leptin ELISA kit from (DRG). A positive correlation of serum leptin levels was observed with markers of insulin resistance. Multiple regression analysis with HOMA-IR as dependent variable demonstrated a statistically significant contribution of fasting insulin levels. This study highlights the role of leptin in alterations in carbohydrate metabolism in patients with PCOS.

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Section: Discussionsupporting

confidence: 92%

Study of Association of Leptin and Insulin Resistance Markers in Patients of PCOS

et al. 2015

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“…The role of high leptin level in women with PCOS is not clear yet, but there is a possibility that woman with PCOS are leptin resistant. 26 In the present study leptin levels in women with concomitant PCOS and MBS were significantly higher than women with PCOS only. We found leptin values of those two groups 41.584±13.06 versus 31.72±7.447, respectively (p=0.001).…”

supporting

confidence: 45%

Evaluation of different biochemical markers in prediction of metabolic syndrome in polycystic ovary syndrome patients

Radwan

Youssry

El-saadany

et al. 2017

Int J Reprod Contracept Obstet Gynecol

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Background: Polycystic ovary syndrome (PCOS) is the commonest cause of chronic hyperandrogenic anovulation. Insulin resistance and compensatory hyperinsulinemia are keys of the pathogenesis of PCOS. It is also considered as a metabolic disorder. Since the components of metabolic syndrome (MBS) namely obesity, glucose intolerance, dyslipidemia, and hypertension are the common features of this syndrome. The association between MBS and PCOS can be explained by different theories as insulin resistance, obesity, and related adipose tissue factors (adipocytokines) independent of insulin resistance are the main pathogenic contributors to both disorders.Methods: A total of 143 women with PCOS were recruited as study subjects. All participants were subjected to anthropometric measurements, clinical assessment, and biochemical tests [fasting glucose, fasting insulin, and homeostatic model assessment-insulin resistance (HOMA-IR)]. Hormonal profile particularly leptin and homocysteine levels were also evaluated.Results: 25 patients (17.4%) out of 143 women with PCOS met the criteria for MBS. Patients with MBS had significantly higher body mass index, blood pressure, HOMA-IR, leptin, and homocysteine levels compared to PCOS only patients. When HOMA-IR cut off was ≥4.3 sensitivity and specificity were 90%, 88.6%, but when leptin level was ≥34.5 the corresponding statistics were 79.6%, 75.5%.Conclusions: Serum leptin, homocysteine, HOMA-IR as well as other biochemical markers are significantly higher in women with PCOS and MBS compared to PCOS only women. PCOS is associated with various factors like insulin resistance, obesity, and dyslipidemia. Consequently, adipocytokines and HOMA-IR play important role in the prediction of MBS in patients with PCOS.

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“…This again suggests that peripheral vascular distensibility reflects both obesity and PCOS (perhaps through IR) as independent variables. However, in a recent pilot study, it has been shown that FMD in both normal weight and overweight PCOS subjects was attenuated to the same degree in overweight subjects without PCOS (34), but the sample size was small in this study.…”

Section: Cvr Markers By Imagingmentioning

confidence: 71%

MECHANISMS IN ENDOCRINOLOGY: Recent advances in cardiovascular aspects of polycystic ovary syndrome

Sathyapalan

Atkin²

2012

European Journal of Endocrinology

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Polycystic ovary syndrome (PCOS) has been associated with increased cardiovascular risk (CVR) markers, but population studies have not clarified whether there is an increase in cardiovascular morbidity and mortality. Four different PCOS phenotypes resulted from the Rotterdam criteria that may differ in their CVR potential, thus introducing further complexity. This has led to studies using surrogate CVR markers including biomarkers in blood and imaging such as flow-mediated vasodilatation. In PCOS, both peripheral and central insulin resistance (IR) have been shown. Weight loss has been shown to improve IR and visceral fat, while insulin sensitizer therapies with metformin or thiazolidinediones improve IR and endothelial dysfunction. IR is also found in non-alcoholic fatty liver disease that in turn is very common in PCOS; studies have suggested that IR may be improved by treatment with metformin and omega-3 fish oils. PCOS patients have a more dyslipidemic phenotype that is worse in 'classical PCOS' associated with a higher CVR. Studies with atorvastatin and simvastatin have reported a decrease in the lipid parameters and an improvement in CVR indices including IR, but it is unclear whether this is due to their lipid-lowering action or a pleiotropic effect of the statin. In this expert opinion review, the relevant literature published during the last 2 years was considered. It focuses on some recent important data that has emerged while also exposing the gaps that remain in our knowledge that need to be addressed.

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Endothelial function and its relationship to leptin, homocysteine, and insulin resistance in lean and overweight eumenorrheic women and PCOS patients: a pilot study

Cited by 41 publications

References 36 publications

Study of Association of Leptin and Insulin Resistance Markers in Patients of PCOS

Study of Association of Leptin and Insulin Resistance Markers in Patients of PCOS

Evaluation of different biochemical markers in prediction of metabolic syndrome in polycystic ovary syndrome patients

MECHANISMS IN ENDOCRINOLOGY: Recent advances in cardiovascular aspects of polycystic ovary syndrome

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