Endothelial Function and Novel Vascular Risk Factors in Pseudoexfoliation Syndrome

Mean Platelet Volume in Pseudoexfoliation Syndrome and Glaucoma

“…It is reported that PEX is a systemic disease and may be a risk factor for cardiovascular diseases. Association of PES with hypertension, angina, myocardial infarction, or stroke has been described in the literature (7, 8, 14, 15). Pseudoexfoliation syndrome incidence has been reported twofold increment in patients with a history of TIA (16).…”

“…Electron microscopic studies showed the presence of PEX material in vascular walls and many organs of the body (2, 18). There are new studies indicating vascular endothelial dysfunction in patients with PES (8, 19). Endothelium is defined as a functional barrier between vascular wall and blood flow.…”

“…It is shown that reduced endothelial production of prostacyclin and nitric oxide promotes increased activation of platelets (24). Accumulation of PEX material in the vessel wall causes endothelial dysfunction (8, 18, 19). Several studies have demonstrated that atherosclerotic lesions associated with PEX endothelial dysfunction had been shown to be an important role in the development of atherosclerosis and complications of atherosclerotic plaque (8, 19).…”

Mean platelet volume in patients with retinopathy of prematurity

“…Kliniğimizde gerçekleştirdiğimiz bir çalışmada psödoeksfoliasyonlu ve psödoeksfoliatif glokomlu olgularda OTH değerlerinin kontrol grubuna göre anlamlı olarak yüksek olduğunu saptadık [6]. Bu çalışmada OTH yüksekliğinin nedeni olarak psödoeksfoliatif materyalin endotelde birikimine bağlı endotel hücre yetmezliği neticesi oluşabileceği öne sürülmüştür [17]. Buna karşın endotel hücre fonksiyonunun etkilendiği aktif oküler Behçet hastalarında ise OTH değerleri ile hastalık ciddiyeti ve retinal tromboz riski arasında ilişki gösterilememiştir [7,18].…”

Evaluation of Carotid Intima Media Thickness and Renal Artery Resistive Index in Patients With Pseudoexfoliation Syndrome: A Prospective Case-Control Study

“…In a previous study, a significant difference in CIMT was detected between PES patients and the control group (0.12 vs., 0.07, P < 0.001) and the authors concluded that these results may be related to structural changes based on PEM accumulation. 17 In another study, the mean CIMT values were 0.8 ± 0.2 and 0.7 ± 0.1 mm in the PES and control groups, respectively. 18 Also, in a more recent study, it was found that CIMT was significantly increased in patients with PEX.…”