Endothelial function and proinflammatory cytokines in patients with ischemic heart disease and dilated cardiomyopathy

Tentolouris, Costas; Tousoulis, Dimitris; Antoniades, Charalambos; Kotsopoulou, Maria; Trikas, Athanasios; Toutouzas, Pavlos; Stefanadis, Christodoulos

doi:10.1016/j.ijcard.2003.08.002

Cited by 72 publications

(45 citation statements)

References 22 publications

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“…While this phenomenon may have a complex basis, there is good evidence that it is in large part endothelium-dependent. [20][21][22][23][24] Second, the tachycardic response to handgrip remained stable during the initial 2 weeks of Table 5 Absence of effect of 4 weeks physical training on resting arterial wall stiffness (see Figure 1 for Time course of circulatory adaptations to training Á Murray et al training when resting BP and vascular conductance were changing. Third, in the only other study that has noted early reduction in BP with training, this was observed to occur considerably in advance of any change in plasma catecholamine levels.…”

Section: Discussionmentioning

confidence: 99%

Rapid onset and offset of circulatory adaptations to exercise training in men

2006

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Chronic aerobic exercise lowers blood pressure (BP), peripheral resistance and cardiac work, and is used widely in antihypertensive and cardiac rehabilitation programmes. In this study, we tested the hypothesis that the cardiovascular benefits of training would occur progressively over several weeks and would diminish over a similar time course on termination of training. In all, 17 young, healthy men undertook a 4-week programme of cycle ergometry (30 min at 60% VO 2peak 3-4 times/week) and 13 subjects matched for age, body mass index and fitness acted as controls. Resting BP and rate-pressure product (RPP) had fallen significantly after only 1 week's training and reached a nadir after 2 weeks training. At this time, BP had fallen from 12177/ 6676 to 11075/5777 mmHg and resting RPP had fallen from 85710 to 7179 (mmHg (beats min À1 )) À2 (Po0.001 each). In parallel, resting forearm conductance had risen from 0.02670.010 to 0.05270.029 (ml min À1 ) 100 ml À1 mmHg À1 and peak reactive hyperaemia following 3 min brachial artery occlusion was increased from 0.10570.031 to 0.20970.041 (ml min À1 ) 100 ml À1 mmHg À1 (Po0.001 each). No significant further circulatory changes occurred over weeks 3-4 of training. On cessation of training, all values returned to pretraining levels within between 1 (SBP, RPP, vascular conductance) and 2 (DBP, MAP, heart rate, reactive hyperaemia) weeks. The results indicate that the optimal cardiovascular benefits of moderate exercise occur rapidly. At least with short training programmes, the benefits regress once training stops just as quickly as they appeared.

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Section: Discussionmentioning

confidence: 99%

Rapid onset and offset of circulatory adaptations to exercise training in men

2006

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“…High levels of adiponectin may simply reflect the hyper-catabolic state in severe heart failure. 40 McEntegart et al 43 have recently shown that adiponectin levels are increased in patients with heart failure in the presence of cachexia. Therefore, it is necessary to clarify whether increased levels of adiponectin may be involved in the pathogenesis of heart failure or if they simply reflect the degree of cachexia in these patients.…”

Section: Obesity and Adiponectinmentioning

confidence: 99%

“…In fact, adiponectin levels are positively correlated with the levels of brain natriuretic peptide and the severity of ventricular dysfunction estimated according to the New York Heart Association (NYHA). 40,41 Moreover, it is suggested that adiponectin predisposes mortality and morbidity in patients with heart failure. 42 Considering the vasoprotective and cardioprotective properties of adiponectin, the results above are easily explained.…”

Section: Obesity and Adiponectinmentioning

confidence: 99%

Relationship between adiponectin, obesity and insulin resistance

Balsan¹,

Vieira²,

Oliveira³

et al. 2015

Rev. Assoc. Med. Bras.

148

100

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Conflict of interest: noneObjectives: the conditions of obesity and overweight pose a major risk for a number of comorbidities, including clinical syndromes resulting from atherosclerotic disease. Recent studies strongly indicate that adipose tissue is an active endocrine organ that secretes bioactive factors such as adipokines. Adiponectin appears to have a regulatory role in the mechanism of insulin resistance and in the development of atherosclerosis. This systematic review aims to evaluate the anti-atherogenic effects of adiponectin and its properties to improve and mimic metabolic and vascular actions of insulin and its influence on endothelial function. Methods: a qualitative, exploratory and literature review was performed in the PubMed, Portal Capes and Scielo databases using as key-words "adiponectin", "obesity", "insulin resistance", "anti-inflammatory", "therapeutic strategies" and "future prospects". Results: evidence suggests that adiponectin has anti-atherogenic properties with anti-inflammatory effects on the vascular wall. Moreover, it modifies the vascular intracellular signaling and has indirect antioxidant effects on the human myocardium. On the other hand, there are studies suggesting that increased levels of adiponectin are paradoxically associated with a worse prognosis in heart failure syndrome, although the mechanisms are not clear. Conclusion: it is not clear whether adiponectin levels have any clinical significance for risk stratification in cardiovascular disease or if they simply reflect the activation of complex underlying mechanisms. Changes in lifestyle and some drug treatments for hypertension and coronary heart disease have shown significant effect to increase adiponectin levels, and simultaneously decrease in insulin resistance and endothelial dysfunction.

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“…Diminished FBF is associated with increased thickness of the tunica media of the artery as well as presence of CAD and the risk factors associated with it. 16,34,35 Forearm blood flow can also be used to monitor the changes to the endothelial function after interventions for cardiovascular risk factors. 36 Environmental and physiological variables, such as room temperature, age, race, hormonal state, phase of menstrual cycle, anxiety, and prandial state, can influence the magnitude of FBF responses.…”

Section: Impedance Plethysmography and Dorsal Hand Vein Compliancementioning

confidence: 99%

Menopause, Estrogens, and Endothelial Dysfunction: Current Concepts

Maturana

Irigoyen

Spritzer

2007

Clinics

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Maturana MA, Irigoyen MC, Spritzer PM. Menopause, estrogens, and endothelial dysfunction: current concepts. Clinics. 2007;62(1):77-86. Menopause is defined as the permanent cessation of menses. Cardiovascular disease is the leading cause of death among postmenopausal women in developed countries. The disparity between the incidence of cardiovascular disease among women in pre-and postmenopause has been ascribed to the actions of endogenous estrogen on the cardiovascular system and, particularly, on the vascular endothelium. The endothelium plays an important role in cardiovascular homeostasis, either through the vascular tonus and its regulation, or through coagulation and the inflammatory response. Endothelial dysfunction is implicated in the genesis of atherosclerosis and other chronic disorders, such as diabetes mellitus and hypertension. The pharmacological use of estrogen exerts influence on the circulating levels of markers of vascular tonus, and inflammation, as well as prothrombotic, and fibrinolytic markers, but the impact of these changes on the atherosclerotic disease is still uncertain.

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Endothelial function and proinflammatory cytokines in patients with ischemic heart disease and dilated cardiomyopathy

Cited by 72 publications

References 22 publications

Rapid onset and offset of circulatory adaptations to exercise training in men

Rapid onset and offset of circulatory adaptations to exercise training in men

Relationship between adiponectin, obesity and insulin resistance

Menopause, Estrogens, and Endothelial Dysfunction: Current Concepts

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