Endothelial function as predictor in patients with coronary syndrome treated by percutaneous coronary intervention

Cheng, Xiaofeng; He, Yun; Fan, Hua-ping; Liu, Ting; Pan, Wenxu; Wang, Ke; Jin, Jun

doi:10.1042/bsr20180732

Cited by 4 publications

(3 citation statements)

References 24 publications

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“…The system software automatically calculated the reactive hyperemia index (RHI) as the ratio of the average pulse wave amplitude (PWA) during a one-minute period following 90 s of reactive hyperemia to the average PWA during a three-to-five-minute baseline period, with the same ratio in the non-occluded arm serving as a control [ 30 ]. The RHI measures peripheral microvascular function in the digital vasculature that reflects, in part, nitric oxide-dependent vasodilation [ 31 , 32 , 33 ]. Relationships between the RHI response and circulating nitrate and epoxyeicosatrienoic acid levels have been reported [ 34 , 35 ].…”

Section: Methodsmentioning

confidence: 99%

The Effect of Hokkaido Red Wines on Vascular Outcomes in Healthy Adult Men: A Pilot Study

Charoenwoodhipong,

Holt,

Keen

et al. 2023

Nutrients

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Moderate red wine intake has been associated with lower cardiovascular mortality, due in part to the intake of polyphenols and anthocyanins, whose content can vary from varietal and year of harvest. This study assessed the vascular effects in response to a single intake of 2015 and 2018 Zweigelt red wines from Hokkaido, Japan. Healthy men were randomly assigned to consume 240 mL each of a red wine, or a sparkling white grape juice as a control in a randomized three-arm cross-over design with a 7 day washout between arms. The augmentation index (AI; a measure of arterial stiffness) and AI at 75 beats/min (AI75), reactive hyperemia index, systolic and diastolic blood pressure (SBP and DBP, respectively), and platelet reactivity were assessed at baseline and two and four hours after each beverage intake. Changes from the baseline were analyzed using a linear mixed model. Significant treatment effects (p = 0.02) were observed, with AI 13% lower after the intake of the 2015 or 2018 vintages compared to the control. Intake of the 2018 vintage reduced SBP and DBP (−4.1 mmHg and −5.6 mmHg, respectively; p = 0.02) compared to the 2015 wine and the control drink. The amount of hydroxytyrosol in the 2018 wine was almost twice the amount as in the 2015 wine, which may help explain the variable blood pressure results. Future studies exploring the vascular effects of the same red wine from different vintage years and different phenolic profiles are warranted.

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Section: Methodsmentioning

confidence: 99%

The Effect of Hokkaido Red Wines on Vascular Outcomes in Healthy Adult Men: A Pilot Study

Charoenwoodhipong,

Holt,

Keen

et al. 2023

Nutrients

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show abstract

“…And abnormal vascular endothelial function is a known prognostic indicator in children with familial cardiomyopathies (Tavares et al, 2012). Additionally, ED can also be used to predict future restenosis and major cardiovascular events in acute coronary syndrome patients treated with percutaneous coronary intervention (Yamamoto et al, 2014;Cheng et al, 2018).…”

Section: Vascular Endothelial Dysfunctionmentioning

confidence: 99%

The impact of periodontitis on vascular endothelial dysfunction

Ouyang

2022

Front. Cell. Infect. Microbiol.

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Periodontitis, an oral inflammatory disease, originates from periodontal microbiota dysbiosis which is associated with the dysregulation of host immunoinflammatory response. This chronic infection is not only harmful to oral health but is also a risk factor for the onset and progress of various vascular diseases, such as hypertension, atherosclerosis, and coronary arterial disease. Vascular endothelial dysfunction is the initial key pathological feature of vascular diseases. Clarifying the association between periodontitis and vascular endothelial dysfunction is undoubtedly a key breakthrough for understanding the potential relationship between periodontitis and vascular diseases. However, there is currently a lack of an updated review of their relationship. Therefore, we aim to focus on the implications of periodontitis in vascular endothelial dysfunction in this review.

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“…Endothelial dysfunction is the earliest stage of an atherosclerotic process. Two non-invasive markers of endothelial dysfunctions, namely, flow-mediated dilation (FMD) and reactive hyperaemia peripheral arterial tonometry (RH-PAT), are currently available (9). A comparison of the results of FMD and DPN was reported previously (10,11).…”

Section: Introductionmentioning

confidence: 99%

Small Fibre Neuropathy Is Associated With Impaired Vascular Endothelial Function in Patients With Type 2 Diabetes

et al. 2021

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Diabetic polyneuropathy (DPN) and endothelial dysfunction are prevalent complications of diabetes mellitus. Currently, there are two non-invasive markers for endothelial dysfunction: flow-mediated dilation and reactive hyperaemia peripheral arterial tonometry (RH-PAT). However, the relationship between diabetic small fibre neuropathy and macroangiopathy remains obscure thus far. Corneal confocal microscopy (CCM) has emerged as a new diagnostic modality to assess DPN, especially of small fibre. To clarify the relationship between diabetic small fibre neuropathy and vascular dysfunction, we aimed to determine the functions of peripheral nerves and blood vessels through clinical tests such as nerve conduction study, coefficient of variation in the R-R interval, CCM, and RH-PAT in 82 patients with type 2 diabetes. Forty healthy control subjects were also included to study corneal nerve parameters. Correlational and multiple linear regression analyses were performed to determine the associations between neuropathy indices and markers for vascular functions. The results revealed that patients with type 2 diabetes had significantly lower values for most variables of CCM than healthy control subjects. RH-PAT solely remained as an explanatory variable significant in multiple regression analysis for several CCM parameters and vice versa. Other vascular markers had no significant multiple regression with any CCM parameters. In conclusion, endothelial dysfunction as revealed by impaired RH-PAT was significantly associated with CCM parameters in patients with type 2 diabetes. This association may indicate that small fibre neuropathy results from impaired endothelial dysfunction in type 2 diabetes. CCM parameters may be considered surrogate markers of autonomic nerve damage, which is related to diabetic endothelial dysfunction. This study is the first to report the relationship between corneal nerve parameter as small fibre neuropathy in patients with type 2 diabetes and RH-PAT as a marker of endothelial dysfunction.

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Endothelial function as predictor in patients with coronary syndrome treated by percutaneous coronary intervention

Cited by 4 publications

References 24 publications

The Effect of Hokkaido Red Wines on Vascular Outcomes in Healthy Adult Men: A Pilot Study

The Effect of Hokkaido Red Wines on Vascular Outcomes in Healthy Adult Men: A Pilot Study

The impact of periodontitis on vascular endothelial dysfunction

Small Fibre Neuropathy Is Associated With Impaired Vascular Endothelial Function in Patients With Type 2 Diabetes

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