Endothelial miR-30c suppresses tumor growth via inhibition of TGF-β–induced Serpine1

McCann, James V.; Xiao, Lin; Kim, Dae Joong; Khan, Omar F.; Kowalski, Piotr S.; Anderson, Daniel G.; Pecot, Chad V.; Azam, Salma H.; Parker, Joel S.; Tsai, Yi-Hsuan; Wolberg, Alisa S.; Turner, Stephen D.; Tatsumi, Kohei; Mackman, Nigel; Dudley, Andrew C.

doi:10.1172/jci123106

Cited by 73 publications

(63 citation statements)

References 78 publications

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“…It has been found that miR-30c was low expressed in breast cancer [31], prostate cancer [32], colon cancer [33], medulloblastoma [34], as well as lung cancer [35], gastric cancer [36]and multiple myeloma [37], compared with these corresponding adjacent tissues. Increasing research shows miR-30c can be regulated or mutated by oncogenic transcription factors and cancer-associated genes.…”

Section: The Function Of Mir-30c In Cancer Progressionmentioning

confidence: 99%

Role of MicroRNA-30c in cancer progression

et al. 2020

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MicroRNAs (miRNAs or miRs) is a non-coding small RNA of a type of 18~24 nucleotide-regulated gene that has been discovered in recent years. It mainly degrades the target gene mRNA or inhibits its translation process through the complete or incomplete bindings with 3'UTR of target genes, followed by the regulation of individual development, apoptosis, proliferation, differentiation and other life activities through the post-transcriptional regulation. Among many miRNAs, the microRNA family, miR-30, plays diverse roles in these key process of neoplastic transformation, metastasis, and clinical outcomes in different cancer progression. As key member of miR-30, miR-30c is regulated by oncogenic transcription factors and cancer progression related genes. Recently, numerous studies have demonstrated that the aberrant expression of miR-30c was significantly associated with the majority of human cancer progression. In this review, the diverse roles of miR-30c in different cancer progression such as the cellular and molecular mechanisms, the potential applications in clinics were summarized to speculate the benefits of miR-30c over-expression in cancer treatment and prognosis.

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Section: The Function Of Mir-30c In Cancer Progressionmentioning

confidence: 99%

Role of MicroRNA-30c in cancer progression

et al. 2020

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“…Immune infiltrating cells induce wound-like inflammation in the tumor microenvironment, further assisting in the development of malignant cancers. Poor perfusion of solid tumors leads to high levels of hypoxia and low metabolite availability, and the healing response responds to these via angiogenesis [7,8]. Leaky vasculature results in high osmolarity in the tumor microenvironment.…”

Section: Introductionmentioning

confidence: 99%

Endoplasmic Reticulum Stress Pathway, the Unfolded Protein Response, Modulates Immune Function in the Tumor Microenvironment to Impact Tumor Progression and Therapeutic Response

Ramirez

Hernandez²,

Soto-Pantoja

et al. 2019

IJMS

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Despite advances in cancer therapy, several persistent issues remain. These include cancer recurrence, effective targeting of aggressive or therapy-resistant cancers, and selective treatments for transformed cells. This review evaluates the current findings and highlights the potential of targeting the unfolded protein response to treat cancer. The unfolded protein response, an evolutionarily conserved pathway in all eukaryotes, is initiated in response to misfolded proteins accumulating within the lumen of the endoplasmic reticulum. This pathway is initially cytoprotective, allowing cells to survive stressful events; however, prolonged activation of the unfolded protein response also activates apoptotic responses. This balance is key in successful mammalian immune response and inducing cell death in malignant cells. We discuss how the unfolded protein response affects cancer progression, survival, and immune response to cancer cells. The literature shows that targeting the unfolded protein response as a monotherapy or in combination with chemotherapy or immunotherapies increases the efficacy of these drugs; however, systemic unfolded protein response targeting may yield deleterious effects on immune cell function and should be taken into consideration. The material in this review shows the promise of both approaches, each of which merits further research.

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“…EBV was associated with B lymphoma such as Burkitt, Hodgkin and Diffuse Large B cell Lymphomas (DLBCL) [3]. The expression of miR-30c was positively correlated to survival of breast cancer patients [38,39]. Loss of miR-424 was associated with aggressiveness of breast cancers in human.…”

Section: Circrnaome Of Ebv Sponged Mirnas Of Host Cells Involved In Mmentioning

confidence: 99%

Epstein-Barr virus circRNAome as host miRNA sponge regulates virus infection, cell cycle, and oncogenesis

Qiao

Zhao

et al. 2019

Bioengineered

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Epstein-Barr virus (EBV) is an oncogenic virus that infects more than 90% of the world's population. The proteins and miRNAs encoded by EBV are involved in multiple human malignancies. Recently R-resistance RNA-seq demonstrated that EBV-encoded circular RNAs. The current research aims to explore their functions in EBV-associated malignancies. Total 56 miRNAs were sponged by circRNAome. 24 and 9 in EBV host B and epithelial cells out of 56 miRNAs were detectable by miRNAseq. 18 and 5 miRNAs were down-regulated in both types of host cells, respectively, after EBV infection. The network between five miRNAs and their targets included 1414 genes, 1419 nodes, and 2423 edges. These targets were enriched in multiple categories, and most of them were up-regulated in EBV-infected cells. These data represented the first report that EBV circRNAs could sponge the miRNAs to promote the up-regulated expression of their targets, involving in malignancies associated with EBV.

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Endothelial miR-30c suppresses tumor growth via inhibition of TGF-β–induced Serpine1

Abstract: Conflict of interest: DGA has applied for a patent on 7C1 entitled "Conjugated lipomers and uses thereof" (US patent application no. 9238716).

Cited by 73 publications

References 78 publications

Role of MicroRNA-30c in cancer progression

Role of MicroRNA-30c in cancer progression

Endoplasmic Reticulum Stress Pathway, the Unfolded Protein Response, Modulates Immune Function in the Tumor Microenvironment to Impact Tumor Progression and Therapeutic Response

Epstein-Barr virus circRNAome as host miRNA sponge regulates virus infection, cell cycle, and oncogenesis

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