Endothelial nitric oxide synthase gene polymorphisms and the risk of osteonecrosis of the femoral head in systemic lupus erythematosus

Kim, Hak Soo; Bae, Sang Cheol; Kim, Sang Woo; Kim, Shin‐Yoon

doi:10.1007/s00264-013-1966-6

Cited by 21 publications

(14 citation statements)

References 26 publications

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“…Sharma et al suggested that subjects carrying the TT genotype exhibit decreased NO production compared with the GG and GT genotypes, indicating that the activity of eNOS is correlated with the presence of the G allele (Sharma et al, 2014). Polymorphisms in eNOS that cause lower NO synthesis because of reduced NOS expression have been identified, and some of the polymorphisms correlate with the risk of ONFH (Paleolog et al, 1991;Kim et al, 2013). In the present study, our results demonstrated that the eNOS rs2070744 T>C polymorphism increased the risk of ONFH under the allele model.…”

Section: Discussionsupporting

confidence: 63%

“…Additionally, the anabolic effects of estrogen and insulin-like growth factor depend, in part, on the NO produced by eNOS (Lagumdzija et al, 2004;Ponnuswamy et al, 2012;Kim et al, 2013). Sharma et al suggested that subjects carrying the TT genotype exhibit decreased NO production compared with the GG and GT genotypes, indicating that the activity of eNOS is correlated with the presence of the G allele (Sharma et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

“…Next, of the remaining 69 studies, a full review and detailed reading led to the exclusion of 57 studies (12 were not case-control studies; 20 were not relevant to ONHF; 25 were not relevant to VEGF, eNOS, and ABCB1). As a final screening step, 2 of the 12 remaining studies were rejected because the data was irrelevant to the topic Zheng et al, 2014), and thus 10 studies published between 2003 and 2013 (Asano et al, 2003;Koo et al, 2006;Yang and Xu, 2007;Kim et al, 2008;Kuribayashi et al, 2008;He and Li, 2009;Lee et al, 2012;Gagala et al, 2013;Kim et al, 2013) were analyzed in this meta-analysis. A total of 1025 patients with ONFH and 1730 healthy individuals were included, with sample sizes ranging from 48-807.…”

Section: Baseline Characteristicsmentioning

confidence: 99%

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VEGF, eNOS, and ABCB1 genetic polymorphisms may increase the risk of osteonecrosis of the femoral head

Zhou¹,

Gu²,

Wu³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. We investigated the associations between vascular endothelial growth factors (VEGF), endothelial nitric oxide synthase (eNOS), and ATP-binding cassette subfamily B member 1 transporter (ABCB1) polymorphisms and the risk of osteonecrosis of the femoral head (ONFH). Published studies were reviewed and analyzed based on predefined selection criteria. The strength of the association between VEGF, eNOS, and ABCB1 polymorphisms and ONFH risk was evaluated based on the odds ratio with corresponding 95%CIs. Meta-analysis was performed using the Comprehensive Meta-analysis 2.0 software. A total of 135 relevant articles were retrieved, of which 10 studies met the selection criteria, and included a total of 1025 patients with ONFH and 1730 healthy controls. The meta-analysis study results revealed that the VEGF rs2010963 G>C polymorphism increased the risk of ONFH, while the VEGF rs2010963 G>C and ABCB1 rs1045642 C>T polymorphisms increased the risk of ONFH under the allele model. In conclusion, the VEGF, eNOS, and ABCB1 polymorphisms may contribute to ONFH, but further studies including larger sample sizes are needed to confirm the results.

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Section: Discussionsupporting

confidence: 63%

Section: Discussionmentioning

confidence: 99%

Section: Baseline Characteristicsmentioning

confidence: 99%

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VEGF, eNOS, and ABCB1 genetic polymorphisms may increase the risk of osteonecrosis of the femoral head

Zhou¹,

Gu²,

Wu³

et al. 2015

Genet. Mol. Res.

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“…In human beings, NOS3 gene is located on the 7th chromosome q36 with 29 exons and 28 introns, encoding 1203 amino acids. Studies have found several SNPs in NOS3 gene, such as T-786C and A-922G in the promoter region, and Glu298Asp in exon 7 [37][38][39]. In this study, we analyzed the association of NOS3 gene rs1799983 and rs3918181 polymorphisms with the susceptibility to ONFH.…”

Section: Discussionmentioning

confidence: 99%

Association between NOS3 polymorphisms and osteonecrosis of the femoral head

Zhao

Yang

Sun

et al. 2019

Artificial Cells, Nanomedicine, and Biotechnology

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Purpose: This study aimed to detect the association between nitric oxide synthase 3 (NOS3) gene polymorphisms (rs1799983 and rs3918181) and the susceptibility to osteonecrosis of the femoral head (ONFH). Methods: Total 88 ONFH patients (55 non-traumatic ONFH and 33 traumatic ONFH) and 90 healthy controls were recruited in this case-control study. Polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP) was adopted for genotyping NOS3 rs1799983 and rs3918181 polymorphisms. v 2 test was used to calculate differences in genotype and allele frequencies of NOS3 gene polymorphisms between the cases and controls. Relative risk of ONFH was represented using odds ratios (ORs) with corresponding 95% confidence intervals (CIs). Results: The T allele of the polymorphism rs1799983 showed significantly different frequencies between ONFH patients and control groups (p ¼ .046) and carrying this allele significantly decreased the disease risk (OR ¼ 0.521, 95%CI ¼ 0.272-0.997), especially for non-traumatic ONFH (OR ¼ 0.408, 95%CI ¼ 0.179-0.929, p ¼ .029). But genotype frequencies of the polymorphism rs1799983 had no obvious difference between the compared two groups (p > .05 for all). There was no remarkable association between NOS3 rs3918181 polymorphism and NOFH risk (p > .05 for all). Conclusions: NOS3 rs1799983 polymorphism is obviously associated with ONFH and its T allele may be a protective factor against ONFH occurrence in Chinese Han population.

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“…The selected growing pig model reflects the intention of developing a superior intervention for Perthes disease, and the results of this study could also be applicable to traumatically induced or adult onset ONFH. Adult onset ONFH has many causes [29,30]; however, much like Perthes disease, the femoral head presents with necrosis of the bone that may lead to collapse. In such a setting our system could be used on its own, or perhaps in combination with a surgical procedure such as core decompression.…”

Section: Discussionmentioning

confidence: 99%

Local delivery of recombinant human bone morphogenetic proteins and bisphosphonate via sucrose acetate isobutyrate can prevent femoral head collapse in Legg-Calve-Perthes disease: a pilot study in pigs

Cheng

Murphy

Cantrill

et al. 2014

International Orthopaedics (SICOT)

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Purpose Legg-Calve-Perthes disease is a paediatric condition encompassing idiopathic osteonecrosis of the femoral head (ONFH). Preventing collapse and the need for subsequent joint replacement remains the major goal of clinical management. This exploratory study utilises a porcine model of surgically induced ONFH. Methods rhBMP-2 with and without zoledronic acid (ZA) was delivered by intra-osseous injection in the phase-transitioning sucrose acetate isobutyrate (SAIB) in an attempt to prevent femoral head collapse. Epiphyseal quotient (EQ) at eight weeks post-surgery was the primary outcome measure. Heterotopic ossification in the joint capsule and bisphosphonate retention in the femoral head were key secondary outcomes. Results Femoral heads with ONFH and no treatment all collapsed (3/3, EQ<0.4, P<0.05 compared to no ONFH). Local delivery of rhBMP-2/SAIB into the femoral head prevented collapse by EQ measurement one of four samples; however, this specimen still showed evidence of significant collapse. In contrast, the combination of local rhBMP-2 and local ZA prevented collapse in two of four samples. Confocal fluorescence microscopy showed locally dosed bisphosphonate entered and was retained in the femoral head. This group also showed strong Calcein signal, indicating new bone formation. Treatment with rhBMP-2 was associated with a limited amount of heterotrophic ossification in the joint capsules in some specimens. Conclusions Operators reported SAIB to be an efficient way to deliver rhBMP-2 to the femoral head. These data suggest that rhBMP-2 is ineffective for preventing femoral head collapse without the addition of bisphosphonate. Further research will be required to validate the clinical efficacy of a combined local rhBMP-2/bisphosphonate approach.

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Endothelial nitric oxide synthase gene polymorphisms and the risk of osteonecrosis of the femoral head in systemic lupus erythematosus

Cited by 21 publications

References 26 publications

VEGF, eNOS, and ABCB1 genetic polymorphisms may increase the risk of osteonecrosis of the femoral head

VEGF, eNOS, and ABCB1 genetic polymorphisms may increase the risk of osteonecrosis of the femoral head

Association between NOS3 polymorphisms and osteonecrosis of the femoral head

Local delivery of recombinant human bone morphogenetic proteins and bisphosphonate via sucrose acetate isobutyrate can prevent femoral head collapse in Legg-Calve-Perthes disease: a pilot study in pigs

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