Endothelial Progenitor Cells Contribute to Neointima Formation in Rabbit Elastase‐Induced Aneurysm after Flow Diverter Treatment

Abstract

BM-derived EPCs participate in neointima formation and reendothelialization in elastase-induced aneurysm after flow diverter treatment. The EPCs may differentiate into different cell types according to the stages of neointima formation in vivo.

In situ tissue engineering: endothelial growth patterns as a function of flow diverter design

“…At that location and at 60 days, the FDs were completely covered with tissue and advanced endothelialization was found. Our results are in agreement with Li et al 19 regarding the role of CD34+ PCs in the FD endothelialization process. They transfused fluorescent labeled PCs after FD implantation and were later able to identify them on the surface of the FDs.…”

Intravenous transfusion of endothelial colony-forming cells attenuates vascular degeneration after cerebral aneurysm induction

“…ECFCs, a unique population of EPCs, possess high proliferation, self-renewal and in vivo vasculogenic potential (Melero-Martin et al, 2007;Richardson and Yoder, 2011), which show good promise in application of vessel repair (Lavergne et al, 2011). In this study, we found successive ECFCs transfusion retarded CA wall degeneration upon homing to aneurysmal wall (Fang et al, 2012;Li et al, 2013). Growing evidence suggests that degeneration of vessel wall followed by vascular remodeling and aneurysm enlargement is associated with CA prone to rupture (Aoki et al, 2008a; Kataoka et al, 1999).…”

Cellular Mechanisms of Aneurysm Occlusion after Treatment with a Flow Diverter

“…Frosen et al (19) demonstrated that endothelial and neointimal cells were mostly originated from the aneurysm wall, with only a minor contribution from the bone marrow in a mouse model of saccular aneurysm. Li et al (20) transfused fluorescence-labeled cultured endothelial progenitor cells in rabbits treated with flow diverters and observed fluorescence-positive endothelial progenitor cells in the subendothelial space and around flow diverter struts. However, in our immunohistochemical analysis, we did not notice any CD34-positive cells, suggesting that the endothelial cells do not originate from the circulating progenitor cells.…”