Endothelial Progenitor Cells Induce Angiogenesis: a Potential Mechanism Underlying Neovascularization in Encephaloduroarteriosynangiosis

Wang, Qian‐Nan; Zou, Zheng-Xing; Wang, Xiaopeng; Zhang, Qian; Zhao, Yang; Duan, Lian; Bao, Xu

doi:10.1007/s12975-020-00834-9

Cited by 16 publications

(14 citation statements)

References 45 publications

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“…UHF MRI makes this technique more reliable in finding the responsible arteries and assessing the risk of rebleeding. Revascularization surgery was thought to be effective to reduce the risk of rebleeding [ 33 , 34 ], and this technique will provide an objective and sensitive imaging marker for the effectiveness of the surgery.…”

Section: Discussionmentioning

confidence: 99%

Preliminary Study on the Application of Ultrahigh Field Magnetic Resonance in Moyamoya Disease

Yang

et al. 2021

Oxidative Medicine and Cellular Longevity

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Magnetic resonance imaging (MRI) is widely used for the evaluation of moyamoya disease (MMD). In this paper, we describe the features of time-of-flight magnetic resonance angiography (TOF-MRA) and susceptibility-weighted imaging (SWI) at 7 T in a series of MMD patients. In this prospective pilot study, 7 patients (median age: 45.6 years; range: 30-52 years) with MMD and no contraindications for MRI underwent T2-weighted, SWI, and TOF-MRA sequences using a research 7 T head-only scanner. We show that such sequences at ultrahigh field (UHF) represent new and valuable approaches to unravel and characterize MMD. While SWI reveals more remarkable imaging signs related to an improved magnitude and phase contrast imaging, the collateral network pathways in MMD could be excellently delineated using 7 T TOF-MRA. In particular, using SWI and MRA fusion images in UHF MRI helps to improve the detection of bleeding points in hemorrhagic MMD. Our findings indicate that ultrahigh field MRI is very promising to access the severity of the disease and may facilitate revascularization surgery of MMD patients.

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Section: Discussionmentioning

confidence: 99%

Preliminary Study on the Application of Ultrahigh Field Magnetic Resonance in Moyamoya Disease

Yang

et al. 2021

Oxidative Medicine and Cellular Longevity

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“…This may be the reason why the results of the above two clinical experiments are different. In addition, at least 10 6 mononuclear cells in peripherals blood were collected in other study, and EPCs numbers were reported as a percentage of mononuclear cells (Wang et al, 2020). Because of low level of EPCs in peripheral, direct count following with ISHAGE gating would be the promising way.…”

Section: Effect Of Depression On the Quantity Of Epcsmentioning

confidence: 99%

Advances of Endothelial Progenitor Cells in the Development of Depression

Sun

Duan

et al. 2021

Front. Cell. Neurosci.

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Depression is a major psychological disease of human beings. With the severity of depression, it elevates the risk of cardiovascular disease (CVD), especially acute coronary syndrome (ACS), resulting in serious harm to human health. The number of endothelial progenitor cells (EPCs) is closely related to the development of depression. It has been reported that the number of peripheral blood EPCs in patients with depression was reduced. However, effects on the function of EPCs in depression are still unclear. This paper aims to analyze and summarize the research of EPCs in depression, and we envision that EPCs might act as a new target for evaluating the severity of depression and its complications.

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“…Endothelial progenitor cells (EPCs), also known as angioblast, are motivated from bone marrow to peripheral blood to repair the blood vessels injury via differentiating into vascular endothelial cells under physiological or pathological stimulations [ 10 , 11 ]. According to the existed information that EPCs mediated angiogenesis is pivotal for IUA recovery [ 12 , 13 ], this study selected primary EPCs for further investigations. Lipopolysaccharide (LPS) is the main pathogen of gram-negative bacteria [ 14 , 15 ], and according to the existed literature [ 16 ], LPS can be used to induce the cellular and animal models for acute uterine injury (AUI) and IUA, and the biological influences of LPS treatment on EPCs have been investigated [ 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

Bone mesenchymal stem cells-derived miR-223-3p-containing exosomes ameliorate lipopolysaccharide-induced acute uterine injury via interacting with endothelial progenitor cells

et al. 2021

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Bone mesenchymal stem cells (BMSCs) have been used for the treatment of acute uterine injury (AUI)-induced intrauterine adhesion (IUA) via interacting with the endothelial progenitor cells (EPCs), and BMSCs-derived exosomes (BMSCs-exo) may be the key regulators for this process. However, the underlying mechanisms have not been studied. Based on the existed literatures, lipopolysaccharide (LPS) was used to induce AUI in mice models and EPCs to mimic the realistic pathogenesis of IUA in vivo and in vitro . Our data suggested that LPS induced apoptotic and pyroptotic cell death in mice uterine horn tissues and EPCs, and the clinical data supported that increased levels of pro-inflammatory cytokines IL-18 and IL-1β were also observed in IUA patients’ serum samples, and silencing of NLRP3 rescued cell viability in LPS-treated EPCs. Next, the LPS-treated EPCs were respectively co-cultured with BMSCs in the Transwell system and BMSCs-exo, and the results hinted that both BMSCs and BMSCs-exo reversed the promoting effects of LPS treatment-induced cell death in EPCs. Then, we screened out miR-223-3p, as the upstream regulator for NLRP3, was enriched in BMSCs-exo, and BMSCs-exo inactivated NLRP3-mediated cell pyroptosis in EPCs via delivering miR-223-3p. Interestingly, upregulation of miR-223-3p attenuated LPS-induced cell death in EPCs. Collectively, we concluded that BMSCs-exo upregulated miR-223-3p to degrade NLRP3 in EPCs, which further reversed the cytotoxic effects of LPS treatment on EPCs to ameliorate LPS-induced AUI.

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Endothelial Progenitor Cells Induce Angiogenesis: a Potential Mechanism Underlying Neovascularization in Encephaloduroarteriosynangiosis

Cited by 16 publications

References 45 publications

Preliminary Study on the Application of Ultrahigh Field Magnetic Resonance in Moyamoya Disease

Preliminary Study on the Application of Ultrahigh Field Magnetic Resonance in Moyamoya Disease

Advances of Endothelial Progenitor Cells in the Development of Depression

Bone mesenchymal stem cells-derived miR-223-3p-containing exosomes ameliorate lipopolysaccharide-induced acute uterine injury via interacting with endothelial progenitor cells

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