“…Subsequently, H 2 O 2 could be either reduced to a hydroxyl radical, generating a consequent increase in intracellular oxidative stress, or converted into H 2 O by catalase, thereby decreasing oxidative stress (Dröge, 2002). Accordingly, EMT, as well as endothelial-mesenchymal transition, are both stimulated by ROS (Montorfano et al, 2014; Mahalingaiah et al, 2015; Pérez et al, 2016). Increased oxidative stress creates a suitable environment for triggering mesenchymal conversion into epithelial and endothelial cells, and the induction of EMT in patients treated with PD is associated with high glucose concentrations through a mechanism mediated by ROS generation (Davies et al, 2001; Lee et al, 2004; Rhyu et al, 2005; Książek et al, 2007a,b).…”