Endothelin and Free Radicals Modulate Microvascular Responses in Streptozotocin-Induced Diabetic Rats

Bassirat, Maryam; Khalil, Zeinab

doi:10.1006/mvre.1999.2209

Cited by 21 publications

(10 citation statements)

References 30 publications

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“…(Yu, 1994). STZ directly generates oxygen free radical, which induces lipid peroxidation (Spinas, 1999;Bassirat and Khalil, 2000). It is involved in the maintenance of normal cell structure and function, probably through its redox and detoxification reactions.…”

Section: Discussionmentioning

confidence: 99%

Antioxidant effect of tetrahydrocurcumin in streptozotocin–nicotinamide induced diabetic rats

2006

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Section: Discussionmentioning

confidence: 99%

Antioxidant effect of tetrahydrocurcumin in streptozotocin–nicotinamide induced diabetic rats

2006

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“…Hydroxyperoxide and an oxidant can form free radicals with ferrous ion and oxygen radicals. These free radicals can attack the phospholipids of membrane causing lipid peroxidation [22]. Increased concentration of lipid peroxide in the liver can result in decreased activity of cytochrome p 450 and cytochrome b 5 , and this may affect the drug metabolizing activity in chronic diabetes The increased concentration of lipid peroxidation byproducts (TBARS, conjugated dienes and hydroperoxide) in the kidney of diabetic rats may be due to increased breakdown of lipid constituents of renal membrane, thus altering the membrane integrity and function [23].…”

Section: Changes In the Levels Of Tbars Hydroperoxides And Conjugatementioning

confidence: 99%

Anti-Oxidative Effect of Cassia auriculata on Streptozotocin Induced Diabetic Rats

Jeyashanthi¹,

Ashok²

2010

Ind J Clin Biochem

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The anti oxidative effect of administration of 100 mg/kg bw and 200 mg/kg bw of the flower powder of Cassia auriculata (CFP) for 45 days to normoglycemic and diabetic rats (streptozotocin induced) was studied. Anti oxidative effect was not observed in normoglycemic rats in the experiment. There was significant (P > 0.05) increase in the level of Thio Barbituric Acid Reactive Substances (TBARS), hydroperoxide and conjugated dienes and significant (P > 0.05) decrease in the catalase, superoxide dismutase and glutathione peroxidase activities and in the level of ascorbic acid, vitamin E and reduced glutathione in diabetic rats. The flower powder of Cassia auriculata significantly (P > 0.05) decreased the TBARS, hydroperoxide and conjugated dienes and increased the antioxidant enzymes (catalase, superoxide dismutase and glutathione peroxidase) and non enzymic anti oxidants (ascorbic acid, vitamin E and reduced glutathione). The antioxidatve effect of 200 mg/kg bw CFP was significantly (P > 0.05) better than 100 mg/kg bw CFP and the reference drugs (tolbutamide and metformin). The mode of action of CFP remains to be elicited.

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“…Although 75% of the blood flow response to heating is regulated by small C-fiber nociceptors (4), potent local vasodilator compounds such as NO, prostacyclin, and bradykinin can also increase capillary blood flow (1,3), whereas angiotensin II, endothelin, and norepinephrine can cause vasoconstriction (2,3). Blood flow may be shunted away from the skin in the diabetic state because of the loss of neural control over arteriovenous shunts (5)(6)(7).…”

Section: Statistical Analysesmentioning

confidence: 99%

“…Humoral and neurogenic factors affect flow; the more potent vasodilators are nitric oxide (NO), prostacyclin, and bradykinin, whereas vasoconstrictors are angiotensin, endothelin, and norepinephrine (1)(2)(3). Cutaneous vasodilation in the foot dorsum is primarily dependent on neurogenic factors, small C-fiber nociceptors, which account for at least 75% of vasodilation during heating (4).…”

mentioning

confidence: 99%

Cutaneous Blood Flow in Type 2 Diabetic Individuals After an Acute Bout of Maximal Exercise

et al. 2003

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OBJECTIVE -We previously demonstrated a positive association between chronic aerobic exercise and dorsal foot skin blood flow during local heating in type 2 diabetic individuals. Thus, we hypothesized that a prior acute bout of maximal exercise would also have positive effects on postexercise blood flow.RESEARCH DESIGN AND METHODS -Subjects consisted of 32 individuals with type 2 diabetes and 26 nondiabetic control subjects further subdivided based on their physical activity status: diabetic exerciser (DE), diabetic sedentary (DS), control exerciser (CE), or control sedentary. Dorsal foot cutaneous blood flow was measured noninvasively by continuous laserDoppler assessment at baseline and during local heating to 44°C before and after a maximal bout of cycle exercise. Interstitial nitric oxide (NO) levels were measured concurrently in the foot dorsum.RESULTS -Increases in blood flow and its responsiveness to local heating to 44°C were significantly lower in both diabetic groups compared with CE before maximal exercise, but perfusion responsiveness remained lower in DS subjects only after exercise (P Ͻ 0.05). Baseline skin blood flow was not different among groups preexercise, but it was significantly increased postexercise in DE subjects only. Interstitial NO levels were not significantly different at either time. At baseline, groups differed only in HbA 1c , fasting serum glucose, HDL cholesterol, and insulin resistance (homeostasis model assessment method).CONCLUSIONS -All diabetic individuals exhibit a blunted responsiveness of cutaneous blood flow with local heating to 44°C before maximal exercise compared with active nondiabetic individuals, but after an exercise bout, it remains significantly blunted only in diabetic individuals who are sedentary. These findings occur independently of changes in interstitial NO levels.

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Endothelin and Free Radicals Modulate Microvascular Responses in Streptozotocin-Induced Diabetic Rats

Cited by 21 publications

References 30 publications

Antioxidant effect of tetrahydrocurcumin in streptozotocin–nicotinamide induced diabetic rats

Antioxidant effect of tetrahydrocurcumin in streptozotocin–nicotinamide induced diabetic rats

Anti-Oxidative Effect of Cassia auriculata on Streptozotocin Induced Diabetic Rats

Cutaneous Blood Flow in Type 2 Diabetic Individuals After an Acute Bout of Maximal Exercise

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