Endothelin and von Willebrand factor as parameters of endothelial function in idiopathic dilated cardiomyopathy: Different stimuli for release before and after heart transplantation?

Galatius, Søren; Wroblewski, Henrik; Sørensen, Vibeke B.; Bie, Peter; Parving, Hans‐Henrik; Kastrup, Jens

doi:10.1016/s0002-8703(99)70505-3

Cited by 27 publications

(21 citation statements)

References 20 publications

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“…Plasma levels of vWf were not significantly related to any of the variables reflecting severity of heart failure. This finding is in contrast to previous studies that have shown a relation between NYHA-class and vWf levels [8,25], whereas, no association between LVEF and CAMs, or vWf has been reported [2].…”

Section: Discussioncontrasting

confidence: 99%

“…Previous studies examining CAMs and vWf in patients with heart failure, have found elevated levels compared with healthy controls [2][3][4][5]8,18,19]. However, only a minority of these studies have reported on the prevalence of DM among the CHF patients [2,18], and none of them have addressed the influence of DM on the plasma levels of these biomarkers, despite the high prevalence of DM in CHF populations [9,10,13].…”

Section: Discussionmentioning

confidence: 99%

“…von Willebrand factor (vWf) is a glycoprotein that is important for platelet aggregation and adhesion to the endothelium, and is considered as a marker of endothelial dysfunction. Elevated plasma levels of vWf have been reported in patients with CHF [2,4,8].…”

Section: Introductionmentioning

confidence: 99%

“…The mechanisms underlying this finding remain unexplained, but a possible connection with abnormal endothelial function and chronic low grade inflammation in patients with type 2 DM may be of importance. Previous cross-sectional CHF studies, comparing plasma levels of various CAMs and vWf with healthy controls, have not addressed the influence of DM [2][3][4][5]8]. Thus, it is possible that the diabetic subgroups may influence the measurements of these markers.…”

Section: Introductionmentioning

confidence: 99%

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Biomarkers of endothelial dysfunction are elevated and related to prognosis in chronic heart failure patients with diabetes but not in those without diabetes

Kistorp

Chong

Gustafsson

et al. 2008

European J of Heart Fail

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Background: Biomarkers of endothelial dysfunction, such as soluble E-selectin, and von Willebrand factor (vWf) are elevated in patients with chronic heart failure (CHF). The impact of diabetes mellitus (DM) on these biomarkers, and their relation to prognosis remains unknown. Aims: to investigate the impact of DM on plasma levels and the prognostic value of E-selectin and vWf in patients with CHF. Methods and results: Plasma levels of E-selectin and vWf were measured in 195 CHF patients with (n = 48, 24.5%), and without DM, and in 116 age-matched healthy controls. Compared with controls, median plasma E-selectin levels were higher in CHF patients with DM (P = 0.012), but not in CHF patients without DM (P = 0.45); vWf levels were also higher in CHF patients with DM (P b 0.001), but not without DM (P = 0.108). E-selectin was associated with risk of recurrent ischaemic cardiovascular events among CHF patients with DM (HR 2.60; P = 0.009), but not among patients without DM (HR 1.09; P = 0.60) per 1 SD increment in log transformed variable. vWf was not related with outcome in CHF patients with or without DM. Conclusions: Plasma levels of E-selectin and vWf are elevated in CHF patients with DM but not in those without DM. High E-selectin levels may be associated with ischaemic events in patients with DM.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Biomarkers of endothelial dysfunction are elevated and related to prognosis in chronic heart failure patients with diabetes but not in those without diabetes

Kistorp

Chong

Gustafsson

et al. 2008

European J of Heart Fail

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“…As demonstrated in animal models of coronary artery occlusion and reperfusion, localized endothelial swelling and protrusions, are predominantly confined to the capillary bed [9], indicating that endothelium plays an important role in tissue-level perfusion. Endothelin-1 (ET-1) is considered to be indices of endothelial dysfunction that is associated with arterial injury [10,11].…”

Section: Introductionmentioning

confidence: 99%

Tirofiban Preserves Endothelial Junctions and Decreases Endothelin-1

Zhao

2008

Sci Pharm

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It has been verified that glycoprotein IIb/IIIa inhibitor tirofiban can attenuate myocardial no-reflow. Myocardial no-reflow has been associated with alterations in endothelial junctions. In addition, ET-1 is an important mechanism for myocardial no-reflow. However, the effect of tirofiban on endothelial junctions and Endothelin-1 (ET-1) is unknown. Methods: Twenty-eight mini-swines were randomized into 3 study groups: 10 in control, 10 given an intravenous infusion of tirofiban and 8 in sham-operated. Acute myocardial infarction and reperfusion model was created with three-hour occlusion of the left anterior descending coronary artery followed by one-hour reperfusion. Results: In control group, plasma ET-1 significantly increased, ET-1 or VE-cadherin level in the reflow and no-reflow myocardium was significantly higher or lower than that in normal myocardium. Compared with the control group, tirofiban significantly decreased plasma ET-1 and myocardial tissue ET-1, maintained VE-cadherin level. Conclusions: Tirofiban is effective in preserving endothelial junction. This beneficial effect of tirofiban could be partly due to its reduction of ET-1.

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Cocaine use modifies the association between antiretroviral therapy and endothelial dysfunction among adults with HIV infection

Li¹,

Li²,

Chen³

et al. 2019

Journal of Medical Virology

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Cocaine is commonly used among HIV-infected people and may worsen HIV disease progression. In addition, existing evidence suggests a link between antiretroviral regimens and endothelial dysfunction. This study aimed to examine whether the associations of antiretroviral therapy (ART) regimens with endothelial dysfunction may be modified by cocaine use in adults with HIV infection. Between 2003 and 2014, 466 HIV-positive participants residing in Baltimore, Maryland, were enrolled in a study investigating comorbidities associated with HIV/ART. The associations between various risk factors and endothelial dysfunction indicators were examined by robust regression models fitted for the overall subjects and cocaine subgroups, separately. Duration of nonnucleoside reverse-transcriptase inhibitor (NNRTI)-based therapy was negatively associated with plasma vWF:Ag levels in cocaine non-users (β = −.715, SE = .220, P < .05). However, cocaine users on longer-term NNRTI-based regimens had greater plasma endothelin-1 (ET-1) concentrations than their counterparts (β = .003, SE = .001, P < .05). In addition, current cigarette smoking was significantly positively associated with ET-1 concentrations in both cocaine nonusers (β = .609, SE = .164, P < .05) and cocaine users (β = .331, SE = .086, P < .05). In conclusion, cocaine use modified the potential effects of NNRTI-based therapy on biomarkers of endothelial dysfunction. These findings suggested that reduction in cocaine use may improve endothelial function in HIV-infected cocaine users.

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Endothelin and von Willebrand factor as parameters of endothelial function in idiopathic dilated cardiomyopathy: Different stimuli for release before and after heart transplantation?

Cited by 27 publications

References 20 publications

Biomarkers of endothelial dysfunction are elevated and related to prognosis in chronic heart failure patients with diabetes but not in those without diabetes

Biomarkers of endothelial dysfunction are elevated and related to prognosis in chronic heart failure patients with diabetes but not in those without diabetes

Tirofiban Preserves Endothelial Junctions and Decreases Endothelin-1

Cocaine use modifies the association between antiretroviral therapy and endothelial dysfunction among adults with HIV infection

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