Endothelin/sarafotoxin receptor heterogeneity: Evidence for different glycosylation in receptors from different tissues

Bousso-Mittler, D.; Galron, Ronit; Sokolovsky, Mordechai

doi:10.1016/0006-291x(91)90979-h

Cited by 37 publications

(10 citation statements)

References 16 publications

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“…Receptors whose glycosylation appears critical for normal function include those for tumour necrosis factor, thrombin, ET [8] and many more. Receptor glycosylation may be important in inflammation, coagulation, vasomotor regulation and cell growth, all of which may contribute to angiogenesis and collateralization.…”

Section: Discussionmentioning

confidence: 99%

The effect of diabetes on endothelin, interleukin-8 and vascular endothelial growth factor-mediated angiogenesis in rats

et al. 2002

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In diabetes mellitus, there is a problem of both premature atherosclerosis as well as impaired collateralization. Studies were performed using the rat corneal angiogenesis model as a surrogate for collateralization to determine the effect of diabetes mellitus on endothelin (ET)-1, ET-3, vascular endothelial growth factor (VEGF) and interleukin-8 (IL-8)-mediated angiogenesis. In an initial group of experiments, streptozotocin-induced diabetes resulted in impairment of ET-1-mediated angiogenesis from 69% to 32%, but was only impaired from 74% to 59% for ET-3. When rats were fluid-resuscitated, mortality fell, and the incidence of inhibition of angiogenesis decreased for ET-1, but was still at 47%. Inhibition of ET-3-mediated angiogenesis in fluid-resuscitated rats was essentially unaffected from 74% to 75%. Studies of VEGF and IL-8 in fluid-resuscitated rats demonstrated that VEGF-mediated angiogenesis was only inhibited from 49% to 45%, but there was inhibition of IL-8-mediated angiogenesis from 62% to 31%. We concluded that there may be two mechanisms by which ET-1-mediated corneal angiogenesis is inhibited: a decrease in intravascular volume and dynamic forces affecting angiogenesis, and a direct effect of diabetes on some aspect of cell growth or angiogenic process. Diabetes also appeared to inhibit IL-8-mediated angiogenesis, but had very little or no effect on ET-3- or VEGF-mediated angiogenesis.

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Section: Discussionmentioning

confidence: 99%

The effect of diabetes on endothelin, interleukin-8 and vascular endothelial growth factor-mediated angiogenesis in rats

et al. 2002

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“…This assumption was confi rmed by use of iodinated ETs and the screening of cDNA libraries that revealed the existence of several functionally distinct and ubiquitous subtypes of receptors recognized by SRTXs and ETs [52][53][54][55]. These glycosylated proteins [56,57] range in size from 30 to 70 kDa and contain seven potential transmembrane 2836 F. Ducancel Endothelin-like peptides domains likely to be regulated by phosphorylation, and share numerous structural features with other receptors coupled to G proteins. The recombinant forms of these receptors for the different isoforms of ETs and SRTXs are currently classifi ed into two main subtypes, depending on their relative affi nities: ET A -R and ET B -R. The isoforms ET-1 and ET-2 have similar and high affi nities for ET A -R, whereas ET-3 recognizes ET A -R 1000 times less well.…”

Section: Cellular Targets and Biological Activities Of Srtxsmentioning

confidence: 98%

Endothelin-like peptides

Ducancel

2005

Cell. Mol. Life Sci.

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Mammalian endothelins (ETs) and snake venom sarafotoxins (SRTXs) comprise structurally and functionally related potent vasoconstrictor isopeptides that act on the vascular system via identical receptors. This similarity is remarkable, since SRTXs are highly toxic components isolated from the venoms of snakes of the genus Atractaspis of the Atractaspididae family, while ETs are endogenous hormones of the mammalian vascular system. Since the first functional and structural description of SRTXs in 1988, the full extent of their natural diversity has become increasingly apparent, and this has led to the characterization of new families of endothelin-like peptides. Based on a combination of conventional biochemical approaches and the latest molecular biology and mass spectrometry techniques, this review describes the more recent panel of SRTX isopeptides isolated from various snake species within the Atractaspididae family, but also the similarities and differences that exist between sarafotoxins and endothelins in terms of their metabolism, genetic origin, structure and functional sites.

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“…As for the ET A variant, the cellular distribution and physiological significance of these ET B splice variants remains to be determined. Variable ET glycosylation has been described in rats, but no functional significance has been identified (66). Finally, a third ET receptor has been identified in Xenopus laevis , but does not appear to exist in mammals (407).…”

Section: General Biology Of Endothelinmentioning

confidence: 99%

Regulation of Blood Pressure and Salt Homeostasis by Endothelin

Kohan

Rossi

Inscho

et al. 2011

Physiological Reviews

373

459

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Endothelin (ET) peptides and their receptors are intimately involved in the physiological control of systemic blood pressure and body Na homeostasis, exerting these effects through alterations in a host of circulating and local factors. Hormonal systems affected by ET include natriuretic peptides, aldosterone, catecholamines, and angiotensin. ET also directly regulates cardiac output, central and peripheral nervous system activity, renal Na and water excretion, systemic vascular resistance, and venous capacitance. ET regulation of these systems is often complex, sometimes involving opposing actions depending on which receptor isoform is activated, which cells are affected, and what other prevailing factors exist. A detailed understanding of this system is important; disordered regulation of the ET system is strongly associated with hypertension and dysregulated extracellular fluid volume homeostasis. In addition, ET receptor antagonists are being increasingly used for the treatment of a variety of diseases; while demonstrating benefit, these agents also have adverse effects on fluid retention that may substantially limit their clinical utility. This review provides a detailed analysis of how the ET system is involved in the control of blood pressure and Na homeostasis, focusing primarily on physiological regulation with some discussion of the role of the ET system in hypertension.

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Endothelin/sarafotoxin receptor heterogeneity: Evidence for different glycosylation in receptors from different tissues

Cited by 37 publications

References 16 publications

The effect of diabetes on endothelin, interleukin-8 and vascular endothelial growth factor-mediated angiogenesis in rats

The effect of diabetes on endothelin, interleukin-8 and vascular endothelial growth factor-mediated angiogenesis in rats

Endothelin-like peptides

Regulation of Blood Pressure and Salt Homeostasis by Endothelin

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