Endothelioprotective property of the combination of the thioctic acid and rosuvastatin shown in the endothelial dysfunction models

Abstract

During the experiment, the modeling of endothelial dysfunction of male rats was performed by intraperitoneal administration of L-NAME at a dose of 25 mg/kg for 7 days, and the same of female rats was performed by bilateral ovarioectomy and further intraperitoneal administration of L-NAME at a dose of 25 mg/kg for 7. The deficiency of nitric oxide as a result of the NO-synthase blockade was accompanied by the impairment of the endotheliumdependent and independent vasodilatation estimated in the pharmacological tests, which was expressed in the increasing coefficient of endothelial dysfunction. As a result of the research it was discovered that the combined application of thioctic acid at a dose of 50 mg/kg/day with antioxidant features and rosuvastatin at a dose of 0.85 mg/kg/day, which is a lipid-lowering drug, has endothelioprotective effect on the models of L-NAME-induced and hypoestrogen-LNAME-induced deficiency of nitric oxide, which is expressed in prevalence of endotheliumdependent relaxations of vessels and decreasing coefficient of endothelial dysfunction, as well as prevention of increase in nitric oxide production.

Untitled

“…The obtained data confirm efficiency of the drug Detralex of 1000 mg for correction of function of an endothelium and restoration of the NO synthesizing function at experimental endothelial dysfunction that most likely it is bound to augmentation of the activity of antioxidatic enzymes, depression of influence of endothelin-1, and a factor of a necrosis of a tumor alpha. [5] Elongation of the rate of AT in an experiment at group of the animals receiving Detralex is caused by decrease of the phenomenon of a stasis, restoration of a linear blood flow, [6] and also immediate endotelioprotectiv action.…”

“…benzo-g-pirona, the citrus having a natural parentage and contained mainly in a peel. [6] In practical medicine, in particular, angiology gained the greatest distribution diosmin, a hesperidin, rutinum, quercetinum, and their combinations.…”

Combined use of arginase II inhibitors and tadalafil for the correction of monocrotaline pulmonary hypertension

“…The level of development of endothelial dysfunction in the experimental animals, as well as a degree of its correction by the studied pharmaceutical substance, was estimated by the calculated coefficient of endothelial dysfunction (CED), calculated by the formula: CED = SBP SN/SBP AC, where SBP SN is the area of the triangle above the curve of blood pressure recovery in response to intravenous administration of sodium nitroprusside; SBP AC is the area of the triangle above the curve of blood pressure recovery in response to intravenous administration of AC (Korokin et al 2009, Molchanova et al 2016.…”

Пирацетам И Бетагистин: Возможные Механизмы Эндотелиопротекции

“…Накопленный клинический опыт свидетельствует о наличии у пирацетама и бетагистина положительного действия в отношении церебрального кровотока, но их воздействие на периферическую гемодинамику и процессы атеротромбогенеза могут служить предметом дальнейшего изучения. Поиск и изучение средств, улучшающих функцию эндотелия, является важной задачей современной фармакологии [47,62]. Особого внимания заслуживают средства, которые наряду с лечением основного заболевания, снижают риск возникновения других патологий.…”