Endothelium-dependent and cyclooxygenase-dependent cutaneous vasodilatation is blunted in young men with hypertensive parents

Hirst, Amy; Marshall, Janice M.

doi:10.1097/hjh.0000000000001794

Cited by 4 publications

(4 citation statements)

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“…These issues are discussed in more detail below. The present finding that cutaneous dilatation during reactive hyperaemia and in response to ACh was blunted in South Asian ON and South Asian OH women relative to white European ON women, is comparable to our observations in young men who were South Asian or white European and of ON or OH status [12]. We recognize that structural limitation on maximal dilatation of arterioles and capillary rarefaction occurs in essential hypertension [26].…”

Section: Discussionsupporting

confidence: 87%

“…Moreover, in our recent study, young normotensive South Asian men showed blunted dilator responses to acetylcholine (ACh) and reactive hyperaemia in cutaneous microcirculation compared with young normotensive white European men. In both ethnicities, these endothelium-dependent dilator responses were blunted in OH relative to ON men and the disparity was attributable in part to reduced contribution of cyclooxygenase (COX) products, most likely vasodilator prostaglandins [12]. Taken together, this evidence suggests that early markers of endothelial dysfunction, a correlate of CVD, are already present in young South Asian men, especially in those at high familial risk of hypertension.…”

Section: Introductionmentioning

confidence: 93%

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Young South Asian women in the United Kingdom show evidence of blunted endothelium-dependent dilatation: implications for future cardiovascular disease

Ali

Hussein

Marshall

2022

Journal of Hypertension

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Introduction: Prevalence of cardiovascular disease (CVD) is higher in South Asians than white Europeans. The offspring of hypertensive parents (OH) have greater risk of hypertension than offspring of normotensive parents (ON). We hypothesized that endothelium-dependent dilatation is already blunted in young South Asians, relative to young white European women, particularly in South Asian OH women.Methods: In young white European ON, South Asian ON and OH women (18-25 years old; 10 per group) who were normotensive, we recorded cutaneous perfusion by laser Doppler fluximetry during reactive hyperaemia and iontophoresis of acetylcholine (ACh), before and after inhibiting NO synthesis (NOS) or/and cyclooxygenase (COX). In these and an additional 135 age-matched South Asian and white European women, physical activity and life-style factors were assessed by questionnaire.Results: ACh-evoked dilatation was blunted in young South Asians, relative to white European women. It was attenuated by NOS or COX inhibition in white European ON; by NOS inhibition only in South Asian ON, but not OH women. After combined NOS and COX inhibition, AChevoked dilatations were similar to control ACh responses. Similar findings were made for reactive hyperaemia. Questionnaire data indicated young South Asians have lower physical activity levels, fresh fruit and vegetable intake than white European women, South Asian OH being lower than white European ON, or OH women. Conclusion:Endothelium-dependent dilatation is blunted in young South Asians, relative to white European women, especially in South Asian OH in whom NO-dependent and prostaglandin-dependent dilatation is blunted. We suggest improved diet and greater physical activity could be particularly effective in improving endothelium-dependent dilatation and reducing future CVD risk in young South Asian OH women.

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Section: Discussionsupporting

confidence: 87%

Section: Introductionmentioning

confidence: 93%

Young South Asian women in the United Kingdom show evidence of blunted endothelium-dependent dilatation: implications for future cardiovascular disease

Ali

Hussein

Marshall

2022

Journal of Hypertension

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“…Although more prevalent in advanced ages, some pathophysiological abnormalities such as altered autonomic control, 3,4 increased cardiac sympathetic neurotransmission, 5 endothelial dysfunction, 6 and vascular endoplasmic reticulum stress 7 were already observed in young-to middle-aged hypertensive individuals. Experimental evidence suggests that angiotensin II (Ang II) and angiotensin- (1)(2)(3)(4)(5)(6)(7) [Ang-(1-7)], the main active hormones of the renin-angio-tensin system (RAS), are essential players in hypertensioninduced abnormalities. 8,9 Among hypertension-induced end-organ lesions, hypertrophic cardiac remodeling is a well-known characteristic.…”

mentioning

confidence: 99%

Training-Induced Deactivation of the AT<sub>1</sub> Receptor Pathway Drives Autonomic Control and Heart Remodeling During the Transition From the Pre- to Hypertensive Phase in Spontaneously Hypertensive Rats

Costa

Masson

Eichler

et al. 2020

Circ J

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Background: The effects of hypertension and exercise training (T) on the sequential interplay between renin-angiotensin system (RAS), autonomic control and heart remodeling during the development of hypertension in spontaneously hypertensive rats (SHR), was evaluated. Methods and Results: Time course changes of these parameters were recorded in 4-week-old SHR submitted to a T or sedentary (S) protocol. Wistar Kyoto rats served as controls. Hemodynamic recordings were obtained in conscious rats at experimental weeks 0, 1, 2, 4, and 8. The left ventricle (LV) was collected to evaluate RAS gene and protein expression, cardiomyocytes' hypertrophy and collagen accumulation. Pre-hypertensive SHR exhibited augmented AT1R gene expression; at 5 weeks, they presented with elevated pressure, increased LV angiotensinogen and ACE mRNA expression, followed by sympathoexcitation (from the 8 th week onwards). Marked AT1R protein content, myocytes's hypertrophy, collagen deposition and increased pressure variability were observed in 12-weekold sedentary SHR. In addition to attenuating all these effects, T activated Mas receptor expression augmented parasympathetic modulation of the heart, and delayed the onset and reduced the magnitude, but did not block the development of genetic hypertension. Conclusions: The close temporal relationship between changes in the LV ACE-Ang II-AT1R axis, autonomic control and cardiac remodeling at both the establishment of hypertension and during exercise training reveals the essential role played by the AT1R pathway in driving cardiac remodeling and autonomic modulation during the transition from the pre-to hypertensive phase.

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“…В целом, анализ литературы выявил достаточное количество работ [11,14,16], демонстрирующих первичную роль ЭД в развитии АГ у лиц с отягощенной наследственностью по ССЗ, в т. ч. у подростков и молодых людей [17,18].…”

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Endothelial dysfunction in hypertension: cause or effect?

Gorshkov

Fedorovich

Драпкина

2019

Cardiovasc Ther Prev

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Дисфункция эндотелия при артериальной гипертензии: причина или следствие? Горшков А. Ю., Федорович А. А., Драпкина О. М.ФГБУ "Национальный медицинский исследовательский центр профилактической медицины" Министерства здравоохранения Российской Федерации. Москва, Россия Артериальная гипертензия продолжает оставаться пандемией XXI века, являясь основным фактором развития преждевременной смерти. Внедрение визуализирующих методов обследования в клиническую практику выявило высокую распространенность поражения "органов-мишеней", опосредованного гипертензией. Одним из системных "органов-мишеней" при артериальной гипертензии является эндотелий, повреждение которого играет важную роль в инициации сердечно-сосудистого континуума. С другой стороны, нарушение структуры и функции эндотелия рассматривается как возможная причина повышения артериального давления. В этой статье систематизированы данные о причинно-следственной связи между артериальной гипертензией и эндотелиальной дисфункцией, и рассматривается направление дальнейшего изучения функции сосудистого эндотелия.Ключевые слова: эндотелий, эндотелиальная дисфункция, артериальная гипертензия, сердечно-сосудистый риск.Конфликт интересов: не заявлен.

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Endothelium-dependent and cyclooxygenase-dependent cutaneous vasodilatation is blunted in young men with hypertensive parents

Cited by 4 publications

References 40 publications

Young South Asian women in the United Kingdom show evidence of blunted endothelium-dependent dilatation: implications for future cardiovascular disease

Young South Asian women in the United Kingdom show evidence of blunted endothelium-dependent dilatation: implications for future cardiovascular disease

Training-Induced Deactivation of the AT<sub>1</sub> Receptor Pathway Drives Autonomic Control and Heart Remodeling During the Transition From the Pre- to Hypertensive Phase in Spontaneously Hypertensive Rats

Endothelial dysfunction in hypertension: cause or effect?

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