Endothelium dysfunction markers in patients with diabetic retinopathy

Siemianowicz, Krzysztof; Francuz, Tomasz; Gmiński, Jan; Telega, Alicja; Syzdół, Marcin

doi:10.3892/ijmm.15.3.459

Cited by 19 publications

(21 citation statements)

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“…However, it also has been reported that there are no differences in the VCAM-1 and ICAM-1 levels between diabetic patients with or without retinopathy (17,18). Furthermore, it has been reported that only the serum levels of VCAM-1 differ between diabetic patients with or without retinopathy, while the ICAM-1 levels are similar between these groups (27,28), or that only the ICAM-1 levels are increased, with similar VCAM-1 levels, in diabetic patients with retinopathy (22).…”

Section: Discussionmentioning

confidence: 99%

“…In addition, the serum levels of these molecules have been assessed in many studies; however, the results are not consistent (14)(15)(16)(17)(18).…”

Section: Discussionmentioning

confidence: 99%

“…Some studies have reported significant increases in the serum concentrations in patients with DRP compared with that observed in controls or diabetic groups without retinopathy (14)(15)(16). In contrast, other studies have reported no significant differences in these levels between diabetic patients with and without DRP and control groups (17,18).…”

Section: Introductionmentioning

confidence: 98%

See 2 more Smart Citations

The Levels of the Circulating Cellular Adhesion Molecules ICAM-1, VCAM-1 and Endothelin-1 and the Flow-mediated Vasodilatation Values in Patients with Type 1 Diabetes Mellitus with Early-stage Diabetic Retinopathy

et al. 2013

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Objective Endothelial dysfunction plays an important role in the development of diabetic retinopathy. The aim of this study was to evaluate endothelial dysfunction using different approaches in patients with type 1 diabete mellitus with early stages of diabetic retinopathy. For this purpose, we investigated the serum levels of cellular adhesion molecules, including intercellular adhesion molecule (ICAM-1), vascular cell adhesion molecule (VCAM-1) and endothelin-1 (ET-1), which have emerged as specific markers of endothelial dysfunction, and measured the flow-mediated dilatation (FMD), a noninvasive technique used to evaluate endothelial dysfunction. Methods The study group included 59 patients with type 1 diabetes mellitus (DM) and 30 age-matched healthy control subjects. The diabetic patients were divided into two groups according to the ophthalmoscopic findings: Group 1, composed of type 1 diabetic patients having no signs of diabetic retinopathy (DRP), and Group 2, composed of type 1 diabetic patients having findings of the early stages of nonproliferative diabetic retinopathy (NPDR). Results The serum levels of ET-1 (fmol/mL), ICAM-1 (ng/mL) and VCAM-1 (ng/mL) were 8.52±0.699 vs. 478.39±46.22 vs. 728.64±35.081 in the patients without retinopathy, 8.91±1.354 vs. 451.79±48.262 vs. 863.59±62.37 in the diabetic patients with NPDR and 10.73±1.04 vs. 608.15±74.92 vs. 872.95±57.63 in the control group. There were no significant differences in the serum levels of the three molecules between the groups. The FMD values were 6.51±0.46% in the diabetic patients without retinopathy, 6.66±0.29% in the diabetic patients with NPDR and 6.68±0.51% in the control group. No significant differences were found between the groups. Conclusion The early stages of diabetic retinopathy cannot be considered in the evaluation of systemic markers of endothelial dysfunction.

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Section: Discussionmentioning

confidence: 99%

“…In addition, the serum levels of these molecules have been assessed in many studies; however, the results are not consistent (14)(15)(16)(17)(18).…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

See 1 more Smart Citation

The Levels of the Circulating Cellular Adhesion Molecules ICAM-1, VCAM-1 and Endothelin-1 and the Flow-mediated Vasodilatation Values in Patients with Type 1 Diabetes Mellitus with Early-stage Diabetic Retinopathy

et al. 2013

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“…We thus hypothesized that ExCO-C might also increase during LDLT and reflect the severity of tissue injury of the graft due to I/R. In this study, we examined time course changes of ExCO-C during LDLT, and studied their relationship with the serum levels of two important molecular markers of endothelial injury, namely, soluble thrombomodulin (sTM) and intercellular adhesion molecule (ICAM)-1 (16)(17)(18). Transplantation procedure.…”

Section: Introductionmentioning

confidence: 99%

Increased exhaled carbon monoxide concentration during living donor liver transplantation

Matsusaki

Morimatsu²,

Takahashi³

et al. 2008

Int J Mol Med

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“…22 vWF is a glycoprotein that is synthesized in the vascular endothelial cells and binds to coagulation factor VIII. 23 In the blood, it mediates platelet adhesion and aggregation to initiate thrombosis, and an increase of vWF is considered a sign of vascular endothelial cell injury. ET-1 is a powerful endogenous vasoconstrictor that influences the contraction of blood vessels and the proliferation of vascular SMCs.…”

Section: Discussionmentioning

confidence: 99%

Comparative study on the histomorphology and molecular biology of radial artery conduits in patients with diabetes mellitus who underwent coronary bypass surgery

Zou

Chen

et al. 2012

Diabetes and Vascular Disease Research

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We studied the impact of diabetes mellitus (DM) on the radial artery (RA) in 30 patients with DM and 30 non-diabetic patients undergoing coronary artery bypass grafting with autologous RA. RAs were recorded as normal if there was no cellular or stromal tissue between the endothelium and the internal elastic lamina. The RA was normal in 26.7% of diabetic and 76.7% of non-diabetic patients (p = 0.000298). Intimal thickness index and intima:media ratio were higher in the former than in the latter (p < 0.05; p < 0.05), with no significant difference in luminal narrowing (p > 0.05). Electron microscopy scores were lower in the non-diabetic group (p < 0.001); endothelial nitric oxide synthase (eNOS) protein expression and optical density were higher (p < 0.001). Von Willebrand factor and endothelin-1 messenger RNA (mRNA) levels were higher in the DM patients (p < 0.001). The quality of the RA in patients with DM was thus inferior to that in non-diabetic patients. Care should be taken when selecting RA as a conduit in patients with DM.

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Endothelium dysfunction markers in patients with diabetic retinopathy

Cited by 19 publications

References 0 publications

The Levels of the Circulating Cellular Adhesion Molecules ICAM-1, VCAM-1 and Endothelin-1 and the Flow-mediated Vasodilatation Values in Patients with Type 1 Diabetes Mellitus with Early-stage Diabetic Retinopathy

The Levels of the Circulating Cellular Adhesion Molecules ICAM-1, VCAM-1 and Endothelin-1 and the Flow-mediated Vasodilatation Values in Patients with Type 1 Diabetes Mellitus with Early-stage Diabetic Retinopathy

Increased exhaled carbon monoxide concentration during living donor liver transplantation

Comparative study on the histomorphology and molecular biology of radial artery conduits in patients with diabetes mellitus who underwent coronary bypass surgery

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