Endotoxin Temporarily Impairs Canine Colonic Absorption of Water and Sodium

Cullen, Joseph J.; Spates, Stephen T.; Ephgrave, Kimberly S.; Hinkhouse, Marilyn M.

doi:10.1006/jsre.1997.5218

Cited by 17 publications

(9 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition to barrier dysfunction, sepsis also causes changes in gastrointestinal motility and absorption of nutrients. Endotoxin given IV to dogs causes a decrease in the number and strength of jejunal contractions as well as decreased net absorption of water, electrolytes, and glucose from the jejunum, decreased colonic absorption of water and sodium, and increased colonic motility and contractions . These changes can lead to diarrhea, dehydration, and electrolyte abnormalities.…”

Section: Individual Organ System Dysfunctionmentioning

confidence: 99%

Multiple Organ Dysfunction Syndrome in Humans and Animals

Osterbur¹,

Mann

Kuroki

et al. 2014

Veterinary Internal Medicne

View full text Add to dashboard Cite

Multiple organ dysfunction syndrome (MODS), defined as the presence of altered organ function in an acutely ill patient such that homeostasis cannot be maintained without intervention, is a cause of high morbidity and mortality in humans and animals. Many advances have been made in understanding the pathophysiology and treatment of this syndrome in human medicine, but much still is unknown. This comparative review will provide information regarding the history and pathophysiology of MODS in humans and discuss how MODS affects each major organ system in animals.

show abstract

Section: Individual Organ System Dysfunctionmentioning

confidence: 99%

Multiple Organ Dysfunction Syndrome in Humans and Animals

Osterbur¹,

Mann

Kuroki

et al. 2014

Veterinary Internal Medicne

View full text Add to dashboard Cite

show abstract

“…Elimination of the MMC by treating rats with morphine leads to an increase in the level of the enteric flora followed by significant bacterial translocation [10,11]. Sepsis produced by intravenous injection of endotoxin, on the other hand, leads to another form of functional gastrointestinal disability characterized by abnormal absorption, motility, and transit [12][13][14][15][16][17][18][19][20][21]. Infectious conditions such as sepsis and impaired gastrointestinal motility may therefore be inter-related, and may have profound effects on each other.…”

Section: Introductionmentioning

confidence: 99%

Effects of peritoneal injury and endotoxin on myoelectric activity and transit

Tanabe

Calland

Schirmer

2004

Journal of Surgical Research

View full text Add to dashboard Cite

“…(2009),Sumano et al (2004),Kikuvi et al (2001),Valladares et al (1998), Cullen et al (1998), Lloyd et al (1991,Gullichsen et al (1990),Anika and Onyeyili (1989),Onyeyili and Anika (1989),Romanosky et al (1983),Lu et al (1981) and McAfee et al . (2009a,b), Jensen et al (2006, 2004), Post et al (2002), Allaouchiche et al (2001), Lindecrona et al (2000), Agersø et al (1998), Monshouwer et al (1995), Moore et al (1995), Zeng and Fung (1990) and Vellenga et al (1992, 1989) Horse 43 4 Ensink et al (2005), Bucki et al (2004), Rees et al (1999) and Wichtel et al (1992) Cattle 126 14 TerHune et al (2005), Erskine et al (1995), Klein et al (2008), Litterio et al (2007), Washburn et al (2005),Kumar and Malik (1999a,b),Clarke et al (1996Clarke et al ( , 1993,Brown et al (1991b),Holland et al (1992),Mevius et al (1991) andClarke et al (1989) Variability in drug response 215…”

mentioning

confidence: 99%

Patient variation in veterinary medicine: part I. Influence of altered physiological states

Martinez

Modrić

2010

Journal of Veterinary Pharmacology and Therapeutics

View full text Add to dashboard Cite

Martinez, M., Modric, S. Patient variation in veterinary medicine: part I. Influence of altered physiological states. J. vet. Pharmacol. Therap.33, 213–226. In veterinary medicine, the characterization of a drug’s pharmacokinetic (PK) properties is generally based upon data that are derived from studies that employ small groups of young healthy animals, often of a single breed. These are also the data from which population predictions are often generated to forecast drug exposure characteristics in the target population under clinical conditions of use. In veterinary medicine, it is rare to find information on the covariates that can influence drug exposure characteristics. Therefore, it is important to recognize some of the factors that can alter the outcome of PK studies and therefore potentially alter the pharmacological response. Some of these factors are easily identified, such as breed, gender, age, and body weight. Others are less obvious, such as disease, heritable traits, and environmental factors. This manuscript provides an overview of the various stressors (such as disease, inflammation, pregnancy, and lactation) that can substantially alter drug PK. Part II of this series provides an overview of the potential impact of physiological variables such as age, weight, and heritable traits, on drug PK. Ultimately, failure to identify appropriate covariates can lead to substantial error when predicting the dose–exposure relationship within a population.

show abstract

Endotoxin Temporarily Impairs Canine Colonic Absorption of Water and Sodium

Cited by 17 publications

References 22 publications

Multiple Organ Dysfunction Syndrome in Humans and Animals

Multiple Organ Dysfunction Syndrome in Humans and Animals

Effects of peritoneal injury and endotoxin on myoelectric activity and transit

Patient variation in veterinary medicine: part I. Influence of altered physiological states

Contact Info

Product

Resources

About