Endotracheally Administered Gentamicin for the Prevention of Infections of the Respiratory Tract in Patients with Tracheostomy: A Double-Blind Study

Klastersky, Jean; Huysmans, Eric; Weerts, Danièle; Hensgens, Colette; Daneau, Didier

doi:10.1378/chest.65.6.650

Cited by 110 publications

(64 citation statements)

References 13 publications

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“…In particular, gentamicin-resistant Providence strains emerged (15). During the use of polymyxin, there was an insignificant increase in colonization of Serratia species and Proteus species of 2.5% and an increase in colonization with Flavobacterium species of 1.5%, while only one additional patient was colonized with S. aureus.…”

Section: Resultsmentioning

confidence: 99%

“…Since the upper respiratory tract is rapidly colonized during acute illnes and hospitalization (1,14) and since pneumonia often occurs before prolonged controlled ventilation is instituted (12), prevention must be attempted early in the course of a given critical illness (15). Thus, after completion of the pilot study, we received permission from the appropriate hospital committees to put all patients in our RSICU on 2-mo alternating cycles of placebo and polymyxin aerosols to determine the effect on the development of pneumonia.…”

Section: The Journal Of Clinical Investigation Volume 55 March 1975 5mentioning

confidence: 99%

See 1 more Smart Citation

Prevention of gram-negative bacillary pneumonia using polymyxin aerosol as prophylaxis. II. Effect on the incidence of pneumonia in seriously ill patients.

Klick¹,

Moulin²,

Hedley-Whyte³

et al. 1975

J. Clin. Invest.

129

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Section: Resultsmentioning

confidence: 99%

Section: The Journal Of Clinical Investigation Volume 55 March 1975 5mentioning

confidence: 99%

Prevention of gram-negative bacillary pneumonia using polymyxin aerosol as prophylaxis. II. Effect on the incidence of pneumonia in seriously ill patients.

Klick¹,

Moulin²,

Hedley-Whyte³

et al. 1975

J. Clin. Invest.

129

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“…Endotracheally administered aminoglycosides have been shown to improve bacteriologic and clinical outcomes in open studies of nosocomial pneumonia (47,76,78). Brown et al showed that endotracheally administered tobramycin led to significantly better bacteriologic eradication than placebo in a double-blind study of aerobic gram-negative pneumonia (41% involving P. aeruginosa); however, clinical outcome was unaffected (10).…”

Section: Approaches To Specific Infectionsmentioning

confidence: 99%

Antimicrobial agent therapy for Pseudomonas aeruginosa

Korvick

1991

Antimicrob Agents Chemother

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“…Este estudio tiene varios problemas metodológicos como que 52 pacientes tuvieron períodos con y sin polimixina a la vez. Un estudio citado habitualmente como de profilaxis por nebulizaciones 84 corresponde en realidad a una administración profunda de soluciones de gentamicina a través del tubo endotraqueal. Este estudio también tiene limitaciones metodológicas ya que, a pesar de ser doble ciego, se retiraron varios pacientes del análisis ya que tenían infección al inicio del estudio.…”

Section: Las Nebulizaciones Con Antimicrobianos ¿Pueden Servir Como Punclassified

Actualización Consenso Neumonía asociada a ventilación mecánica: Segunda parte. Prevención

Chacón

et al. 2011

Rev. chil. infectol.

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Update. Consensus on Ventilator Associated Pneumonia.Second Part: ProphylaxisVentilator associated pneumonia is a life threatening disease, in spite of advances in its treatment, consequently the development of prevention strategies is a key factor in improving the morbidity and mortality in intensive care units (ICU). The new developments in this fi eld in the last years led to the need to update the recommendations done in 2001. Then, a new search and analysis of scientifi c literature was performed. The obtained data support different strategies highlighting: semi-recumbent position at 45° of patients; incorporation of routinely oral hygiene procedures with chlorhexidine; preference of orotracheal intubation; performing subglotic aspiration; use of standard hand hygiene techniques; not routine change of ventilator circuits; and defi ning bundles to organize the work at ICU. Some strategies were recommended for being of similar effi cacy to others but cost-effective as: use of heat and moisture humidifi cators; and changing humidifi cators every 5 to 7 days. The use of open or closed endotracheal suctioning system does not affect the incidence of pneumonia. Some recommendations were not incorporated because of lack of evidence supporting effectiveness, controversial data or doubtful application to our country as selective digestive decontamination.Key words: Prevention, ventilator-associated pneumonia, guidelines, mechanical ventilation, consensus. Palabras clave: Prevención, neumonía asociada a ventilación mecánica, guías clínicas, ventilación mecánica, consenso. Universidad Austral de Chile, Valdivia (MCA).Hospital San Borja Arriarán, Santiago (LDM).Hospital Padre Hurtado, Santiago. Enfermera Control de IAAS (ECV).Hospital Clínico Universidad IntroducciónL a neumonía asociada a ventilación mecánica (NAVM) se mantiene como una entidad de alta mortalidad que afecta a las poblaciones sometidas a este procedimiento. A pesar de que se han diseñado estrategias para iniciar un tratamiento oportuno y apropiado, mejorando el pronóstico de mortalidad de los enfermos, no es menos cierto que la mortalidad atribuible es aún elevada con una terapia adecuada. Por esto, el desarrollo y ejecución de medidas de prevención adecuadas parece ser uno de los esfuerzos más acertados para la disminución de la morbi-mortalidad asociada a este cuadro.En los últimos nueve años, el desarrollo de la literatura científi ca enfocada a este aspecto ha sido enorme y muy variado, incluyendo nuevos tipos de intervenciones, a la vez que ha intentado esclarecer la utilidad de las más antiguas; por otro lado, en otras se ha logrado tener un mejor dato respecto a su evidencia, así como en algunas, por el poco tiempo de desarrollo que llevan, no ha sido posible dar una recomendación con la misma calidad de fundamento.Como se ha mencionado previamente, este artículo es parte de la actualización del consenso realizado, con anterioridad, por la Sociedad Chilena de Infectología en el año 2001. La metodología nuevamente ha buscado realizar recomendacio...

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Endotracheally Administered Gentamicin for the Prevention of Infections of the Respiratory Tract in Patients with Tracheostomy: A Double-Blind Study

Cited by 110 publications

References 13 publications

Prevention of gram-negative bacillary pneumonia using polymyxin aerosol as prophylaxis. II. Effect on the incidence of pneumonia in seriously ill patients.

Prevention of gram-negative bacillary pneumonia using polymyxin aerosol as prophylaxis. II. Effect on the incidence of pneumonia in seriously ill patients.

Antimicrobial agent therapy for Pseudomonas aeruginosa

Actualización Consenso Neumonía asociada a ventilación mecánica: Segunda parte. Prevención

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