Endovaginal Scanning of the Endometrium Compared to Cytology and Histology in Women with Postmenopausal Bleeding

Karlsson, Bengt; Granberg, S.; Wikland, M.; Ryd, Walter; Norström, Anders

doi:10.1006/gyno.1993.1188

Cited by 72 publications

(38 citation statements)

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“…9,25,34,38 -45 Seven studies were limited to postmenopausal women. 9,13,14,21,24,26,41 All other studies either reported on both premenopausal and postmenopausal women or did not report on the menopausal status of the included patients. One study reported on asymptomatic women only, 38 and 14 studies reported on symptomatic women only.…”

Section: Resultsmentioning

confidence: 99%

The accuracy of endometrial sampling in the diagnosis of patients with endometrial carcinoma and hyperplasia

Dijkhuizen

Mol²,

Brölmann³

et al. 2000

Cancer

118

134

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Section: Resultsmentioning

confidence: 99%

The accuracy of endometrial sampling in the diagnosis of patients with endometrial carcinoma and hyperplasia

Dijkhuizen

Mol²,

Brölmann³

et al. 2000

Cancer

118

134

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“…[6][7][8] Nevertheless, since vaginal bleeding is a common symptom among postmenopausal women, ultrasound has been a useful screening method for determining which symptomatic patients should undergo invasive collection of endometrial samples. In this situation, endometrial thickening, as measured by ultrasonography, correlates better with the presence of endometrial lesions [9][10][11] than among asymptomatic women.…”

Section: Introductionmentioning

confidence: 89%

Hysteroscopy as a standard procedure for assessing endometrial lesions among postmenopausal women

et al. 2007

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CONTEXT AND OBJECTIVES: Endometrial cancer is the most prevalent type of malignant neoplasia of the genital tract. The objective of this study was to calculate the sensitivity, specificity, accuracy and positive and negative predictive values for diagnostic hysteroscopy, in comparison with histopathological tests, for all lesions of the endometrial cavity. DESIGN AND SETTING: Retrospective descriptive study at the public tertiary-level university hospital of Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo. METHODS: Diagnostic hysteroscopy was indicated in the following instances: endometrial thickness > 4 mm in asymptomatic patients; postmenopausal bleeding; and irregular endometrium or endometrium difficult to assess from ultrasound, with or without vaginal bleeding. Ultrasound evaluations were carried out no more than three months prior to hysteroscopy. RESULTS: There were 510 patients, with a mean age of 61.1 ± 2.0 years and mean time elapsed since the menopause of 12.7 ± 2.5 years. Endometrial biopsies were performed on 293 patients (57.5%). Histopathological analysis showed that 18 patients presented endometrial carcinoma or typical or atypical hyperplasia, and none of them presented endometrial thickness of less than 8 mm. No significant differences were found between the median thicknesses of the various benign lesions (p > 0.05). In our data, the sensitivity, specificity, accuracy and positive and negative predictive values for cancer or hyperplasia were 94.4%, 97.0%, 96.8%, 68% and 99.6%, respectively. CONCLUSIONS: Our results suggest that hysteroscopy is valuable as a diagnostic tool for malignant/hyperplastic and benign lesions, except for submucous myomas, for which the sensitivity was only 52.6%.

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“…Transvaginal ultrasonography is a simple, non-invasive imaging method used for the evaluation of anatomic abnormalities which may cause AUB [2,18]. However, there is no consensus on the cut-off value for endometrial thickness [2,7,19,20 ]. Gull B et al reported that in cases with endometrial thickness <4mm endometrial carcinoma was not associated and his findings coincided with other studies in the literature [2,[19][20][21][22].…”

Section: Discussionmentioning

confidence: 53%

“…However, there is no consensus on the cut-off value for endometrial thickness [2,7,19,20 ]. Gull B et al reported that in cases with endometrial thickness <4mm endometrial carcinoma was not associated and his findings coincided with other studies in the literature [2,[19][20][21][22]. However, Buyuk E reported cutoff of 6 mm for endometrial thickness [23].…”

Section: Discussionmentioning

confidence: 85%

“…Davidson KG et al reported that in 5-10% of cases false negative evaluation of endometrium thickness with ultrasonography may occur so that in women with high-risk for cancer endometrial sampling may be considered irrespective to ultrasonography findings [24]. Karlsson et al reported that 97% sensitivity and 81% specificity of TVUS when compared with dilatation and curettage(D&C) results in differentiating normal and pathological endometrium [19]. Auslender et al told that when endometrial thickness 3mm was accepted as cut-off value, unnecessary D&C ratios decreased 45% and endometrial pathologies would not be underdiagnosed [25].…”

Section: Discussionmentioning

confidence: 99%

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The role of Histopathology, Endometrium Thickness and Obstetric History in Abnormal Uterine Bleeding

Cengiz¹

2017

Ann Clin Anal Med

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ÖzetAmaç: Anormal uterin kanamada (AUK) klinik, ultrason bulgularını değerlen-dirmek ve histopatolojik sonuçlarla karşılaştırmak. Gereç ve Yöntem: Toplam 404 AUK'li bayan hasta; Grup I: 18-39 yaş, Grup II: 40-50 yaş, Grup III: >50 yaş olarak sınıflandırıldı. Yaş, parite, kanama paterni, menstruel öykü, labaratuar sonuçları, ultrason ve histopatolojik bulgular değerlendirildi. Bulgular: AUK ile başvuranların yaklaşık yarısı premanopozal grupda idi [196 (48.51%)], bunları postmenopozal grup [150(37.13%)] ve reprodüktif yaş grubu takip ediyordu [58(14.36%)]. En sık görülen kanama paterni menometroraji olup bunu metroraji takip ediyordu. 306 (75.74%) hastada endometrial patolojiler izlenirken 98 (24.26%) hastada normal menstruel pattern izlendi. Endometrium kanseri 7(1.7%) bayanda izlendi. Reprodüktif periodda hormonal düzen-sizlik patern en sık patolojiydi. Premanopozal ve postmenopozal yaş gruplarında endometrial polip dominant patolojiydi. Tüm kanser vakaları postmenopozal gruptaydı. Üçten daha az doğum yapanlardan 4(19.04%) bayanda kanser izlenirken, ≥3 doğum yapanlardan 1(4.76%)'inde görüldü. Vajinal doğum yapanların 4'ünde kanser izlenirken sadece sezeryan ile doğum yapanlarda hiç kanser izlenmedi. Endometrial kalınlığı <4mm olan 109 hastadan, 15(13.76%)'inde düzensiz endometrial proliferasyon ve polip, 1 (0.92%)'inde endometrioid kanser mevcuttu. Endometrial kalınlığı >4mm 295 hastadan, 30 (10.17%)'unda endometrial hiperplazi, 6(2.03%) sında endometrium kanser izlendi. Tartışma: Transvajinal ultrasonografi endometrial kalınlık ve uterin patolojileri değerlendirmede tanısal metod olarak kullanılabilir. Fakat tekrarlayan uterin kanamalarda ultrason bulgularını dikkate almadan endometrial örnekleme yapılmalıdır. Anahtar KelimelerAnormal Uterin Kanama; Endometrial Kalınlık; Parite; Histopatoloji Abstract Aim: To evaluate the clinical manifestations of abnormal uterine bleeding (AUB), ultrasonography findings and compare with histopathological results. Material and Method: A total of 404 women with AUB were classified as; Group I: 18-39 years, Group II: 40-50 years, Group III: >50 years old. Age, parity, bleeding pattern, menstrual history, laboratory results, ultrasonography and histopathological findings were evaluated. Results: Almost half presented with AUB were in the premenopausal group [196 (48.51%)], followed by 150(37.13%) postmenopausal group and 58(14.36%) reproductive age group. The most common bleeding pattern was menometrorrhagia followed by metrorrhagia. Endometrial pathologies were observed in 306 (75.74%) and normal menstrual pattern in 98 (24.26%) participants of AUB. Endometrium cancer was seen in 7 (1.7%) women. In the reproductive period most common pathology was hormonal imbalance pattern. Endometrial polyp was the dominant pathology in premenopausal and postmenopausal age groups. All malignancy cases were in the postmenopausal age group. Malignancy was in 4(19.04%) women who gave birth < 3 and in 1(4.76%) who had ≥3 children. Four women with vaginal delivery had malignancy whereas no maligna...

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Endovaginal Scanning of the Endometrium Compared to Cytology and Histology in Women with Postmenopausal Bleeding

Cited by 72 publications

References 0 publications

The accuracy of endometrial sampling in the diagnosis of patients with endometrial carcinoma and hyperplasia

The accuracy of endometrial sampling in the diagnosis of patients with endometrial carcinoma and hyperplasia

Hysteroscopy as a standard procedure for assessing endometrial lesions among postmenopausal women

The role of Histopathology, Endometrium Thickness and Obstetric History in Abnormal Uterine Bleeding

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