2018
DOI: 10.1136/bmjopen-2018-022359
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Endovascular treatment for symptomatic intracranial artery stenosis: protocol for a systematic review and network meta-analysis

Abstract: IntroductionAtherosclerotic intracranial artery stenosis (ICAS) is one of most common causes of stroke, which is the second-leading cause of death worldwide. Medical, surgical and endovascular therapy are three major treatments for ICAS. Currently, medical therapy is considered as the standard of care for most patients with ICAS, while extracranial to intracranial bypass is only used in rare situations. Balloon angioplasty alone, balloon-mounted stent and self-expanding stent, collectively called endovascular … Show more

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Cited by 11 publications
(12 citation statements)
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“…Posterior circulation stroke takes ~25% of all ischemic stroke cases, and unlike anterior stroke, symptomatic vertebrobasilar atherosclerotic disease is more challenging and has a relatively higher annual recurrence of stroke despite standard medical treatment of antiplatelet agents and statin ( 1 – 3 ), and the symptoms caused by large artery stenosis or occlusion are often devastating. Also, it was associated with a risk of stroke > 20%, as was shown in a pooled data analysis from two studies ( 4 , 5 ). Stenting is becoming a promising therapeutic method for recurrent ischemic events refractory to best medical treatment, but there are also side effects such as procedure-related ischemic stroke or transient ischemic attack (TIA), intracranial hemorrhage, and even death ( 6 , 7 ).…”
Section: Introductionsupporting
confidence: 52%
“…Posterior circulation stroke takes ~25% of all ischemic stroke cases, and unlike anterior stroke, symptomatic vertebrobasilar atherosclerotic disease is more challenging and has a relatively higher annual recurrence of stroke despite standard medical treatment of antiplatelet agents and statin ( 1 – 3 ), and the symptoms caused by large artery stenosis or occlusion are often devastating. Also, it was associated with a risk of stroke > 20%, as was shown in a pooled data analysis from two studies ( 4 , 5 ). Stenting is becoming a promising therapeutic method for recurrent ischemic events refractory to best medical treatment, but there are also side effects such as procedure-related ischemic stroke or transient ischemic attack (TIA), intracranial hemorrhage, and even death ( 6 , 7 ).…”
Section: Introductionsupporting
confidence: 52%
“…Second, we did a Bayesian network analysis by using Markov chain Monte Carlo methods via GeMTC package 0.8 implemented in R 3.2.2. We also assessed study design information and patient characteristics to evaluate the transitivity assumption for reliable data pooling with sufficient similarity between the included trials [18, 19]. Both non-informative uniform and normal prior distributions were used throughout the network meta-analysis [20].…”
Section: Methodsmentioning
confidence: 99%
“…36 Carotid artery stenosis caused by other reasons, including vasculitis, fibromuscular dysplasia, Moyamoya disease, vasospasm and dissection will not be included. 37…”
Section: Types Of Participantsmentioning
confidence: 99%
“…Primary and secondary outcomes will be compared in this NMA. 37 Primary outcomes 1. Mortality, stroke or MI rates in the periprocedural period or during the postoperative period of 30 days.…”
Section: Types Of Outcome Measuresmentioning
confidence: 99%
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