Giant reed is a promising perennial grass providing ligno-cellulosic biomass suitable to be cultivated in marginal lands (MLs) and converted into several forms of renewable energy. This study investigates how much energy, in the form of biomethane, bioethanol, and combustible solid, can be obtained by the cultivation of this species in marginal land of two Italian regions, via the spatially explicit application of the Arungro crop model. Arungro was calibrated in both rainfed/well-irrigated systems, under non-limiting conditions for nutrient availability. The model was then linked to a georeferenced database, with data on (i) current/future climate, (ii) agro-management, (iii) soil physics/hydrology, (iv) land marginality, and (v) crop suitability to environment. Simulations were run at 500 × 500 m spatial resolution in MLs of Catania (CT, Southern Italy) and Bologna (BO, Northern Italy) provinces, characterized by contrasting pedo-climates. At field scale, Arungro explained 85% of the year-to-year variability of measured carbon accumulation in aerial biomass. At the provincial level, simulated energy yields progressively increased from bioethanol, to biomethane, and finally to combustible solid, with average values of 92-115-264 GJ ha−1 in BO and 105-133-304 GJ ha−1 in CT. Mean energy yields estimated for 2030 remained unchanged compared to the baseline, although showing large heterogeneity across the study area (changes between −6/+15% in BO and −16/+15% in CT). This study provides site-specific indications on giant reed current productions, energy yields, and natural water consumption, as well as on their future trends and stability, ready-to-use for multiple stakeholders of the agricultural sector involved in bioenergy planning.