Energy efficiency (EE) is of great concern in cognitive radio networks since the throughput and energy consumption of secondary users (SUs) vary with the sensing time. However, the conditions of the detection probability and false alarm probability should be respected to better protect primary users (PUs) and to improve the sensing performance of SUs. Additionally, the PUs’ minimum averaged power provision should also be regarded as a key problem of interactive linking to SUs. Therefore, an integrated design between the PU and SUs is desired for the coordination of the whole cognitive radio system, especially regarding the satisfaction of EE and performance metrics. This study formulates sensing constraints in a unified way and calculates the minimum SNR of SUs, based on which the essential PU power provision is computed. Furthermore, EE is proved as a decreasing function with the PU’s active ratio, where the maximum EE is obtained corresponding to the minimum QoS requirements of the sensing process. Hence, a bisection-based method is proposed to maximize EE, which is considered as a concave function of SUs’ sensing time and has only one unique optimum. EE’s optimization was analyzed under different fusion rules for diverse SNR conditions. The optimum was also studied with sensing performance targets for various cases of PU power provision.