Energy Levels and Transitions in<sup>71</sup>As from (p, γ) Reaction on<sup>70</sup>Ge

Liu, Y. C.; Hsu, T.H.; Lin, E. K.; Tseng, P. K.; Hsu, C. C.; Wang, C. W.

doi:10.1143/jpsj.39.1

Cited by 10 publications

(4 citation statements)

References 9 publications

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“…The APF-based multichannel gradient computation formalism here also applies in 3D, though with a higher computing cost. For a 3D system with thickness h = 0.56 μm, lateral area a = W 2 = 16h 2 , discretized with grid size Δx = λ/40 at λ = 940 nm, a 3D vectorial APF computation 58 for a multichannel objective evaluation takes 8.3 min using 22 GiB of memory when running on an Intel Xeon 2640v4 node with multithreading; the computing time and memory usage scale as a ( ) 1.6 and a ( ) 1.3 , respectively, for such geometry. Larger areas can be stitched together as in refs 59−62.…”

Section: ■ Conclusionmentioning

confidence: 99%

Fast Multichannel Inverse Design through Augmented Partial Factorization

Li,

Lin,

Hsu

2024

ACS Photonics

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Computer-automated design and discovery have led to high-performance nanophotonic devices with diverse functionalities. However, massively multichannel systems such as metasurfaces controlling many incident angles and photoniccircuit components coupling many waveguide modes still present a challenge. Conventional methods require M in forward simulations and M in adjoint simulations� 2M in simulations in total�to compute the objective function and its gradient for a design involving the response to M in input channels. Here, we develop a formalism that uses the recently proposed augmented partial factorization method to obtain both the objective function and its gradient for a massively multichannel system in a single or a few simulations, achieving over 2 orders of magnitude speedup and reduced memory usage. We use this method to inverse design a metasurface beam splitter that separates the incident light to the target diffraction orders for all incident angles of interest, a key component of the dot projector for 3D sensing. This formalism enables efficient inverse design for a wide range of multichannel optical systems.

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Section: ■ Conclusionmentioning

confidence: 99%

Fast Multichannel Inverse Design through Augmented Partial Factorization

Li,

Lin,

Hsu

2024

ACS Photonics

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“…The EMT program is crucial for processes of tissue remodeling in embryonic development and wound healing (Dongre and Weinberg, 2019), both linked to cell senescence (Huang et al, 2022). Furthermore, many of the molecules secreted by senescent cells, including cytokines, growth factors, and ECM proteins, are known EMT triggers (Krtolica et al, 2001;Parrinello et al, 2005;Yilmaz and Christofori, 2009;Coppe et al, 2010;Acosta et al, 2013;Lamouille et al, 2014;Hoare et al, 2016;Cherubini et al, 2017;Liu et al, 2018;Scott et al, 2019;Hou et al, 2021;Anerillas et al, 2022a). Downstream of membrane receptors, many signaling pathways related to both EMT and senescence are activated along with the MAPKs; these signaling modules include WNT-β-Catenin, NOTCH, SMADs, AKT-mTOR, and STATs (Acosta et al, 2013;Munoz-Espin et al, 2013;Herranz et al, 2015;Laberge et al, 2015;Hoare et al, 2016;Bryson et al, 2017;Kandhaya-Pillai et al, 2017;Gibaja et al, 2019;Anerillas et al, 2020;Anerillas et al, 2022a).…”

Section: Senescence or Apoptosis? Messages From The Emtmentioning

confidence: 99%

MAPKs in the early steps of senescence implemEMTation

Anerillas

Altés

Gorospe

2023

Front. Cell Dev. Biol.

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Evidence is accumulating that the earliest stages of the DNA damage response can direct cells toward senescence instead of other cell fates. In particular, tightly regulated signaling through Mitogen-Activated Protein Kinases (MAPKs) in early senescence can lead to a sustained pro-survival program and suppress a pro-apoptotic program. Importantly, an epithelial-to-mesenchymal Transition (EMT)-like program appears essential for preventing apoptosis and favoring senescence following DNA damage. In this review, we discuss how MAPKs might influence EMT features to promote a senescent phenotype that increases cell survival at the detriment of tissue function.

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“…Matric stiffness associated with enhanced collagen crosslinking may affect the motility of lung cancer cells (Götte and Kovalszky, 2018). XIX collagen, with certain relevance to types XVIII and XV in the BM zone, has been shown to enhance several types of cancer, distinguishing NSCLC from healthy controls (Liu et al, 2016). XVII collagen has been shown to be essential for maintaining epithelial-Mesenchymal transition (EMT) phenotypes and metastasis in lung cancer stem-like cells.…”

Section: Introductionmentioning

confidence: 99%

“…Col XVII inhibits ubiquitination degradation in snails by activating the FAK/ AKT/GSK3β pathway by stabilizing laminin-5. Col XVII and Laminin-5 were overexpressed in patients with LC resection, and the prognosis was the worst (Liu et al, 2016). Laminin, the main structural component of BM, is a strong promoter that promotes cell adhesion, migration, differentiation and proliferation through integrins and other cell receptors on the surface.…”

Section: Introductionmentioning

confidence: 99%

Function and prognostic value of basement membrane -related genes in lung adenocarcinoma

Zhang

Liu

et al. 2023

Front. Pharmacol.

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Background: Lung adenocarcinoma (LUAD) has become a common cause of cancer-related death. Many studies have shown that the basement membrane (BM) is associated with the development of cancer. However, BM-related gene expression and its relationship to LUAD prognosis remains unclear.Methods: BM-related genes from previous studies were used. Clinical and mRNA expression information were obtained from TCGA database. Cox, minimum absolute contraction, and selection operator regression were applied to analyze the selected genes affecting LUAD prognosis. A prognostic-risk model was then established. Furthermore, this study applied Kaplan-Meier analysis to assess the outcomes of high- and low-risk groups, then explored their differences in drug sensitivity. The DSigDB database was used to screen for therapeutic small-molecule drugs.Results: Fourteen prognostic models based on BM-related genes were successfully constructed and validated in patients with LUAD. We also found that independence was a prognostic factor in all 14 BM-based models. Functional analysis showed that the enrichment of BM-related genes mainly originated from signaling pathways related to cancer. The BM-based model also suggested that immune cell infiltration is associated with checkpoints. The low-risk patients may benefit from cyclopamine and docetaxel treatments.Conclusion: This study identified a reliable biomarker to predict survival in patients with LUAD and offered new insights into the function of BM-related genes in LUAD.

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Energy Levels and Transitions in⁷¹As from (p, γ) Reaction on⁷⁰Ge

Cited by 10 publications

References 9 publications

Fast Multichannel Inverse Design through Augmented Partial Factorization

Fast Multichannel Inverse Design through Augmented Partial Factorization

MAPKs in the early steps of senescence implemEMTation

Function and prognostic value of basement membrane -related genes in lung adenocarcinoma

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Energy Levels and Transitions in71As from (p, γ) Reaction on70Ge

Cited by 10 publications

References 9 publications

Fast Multichannel Inverse Design through Augmented Partial Factorization

Fast Multichannel Inverse Design through Augmented Partial Factorization

MAPKs in the early steps of senescence implemEMTation

Function and prognostic value of basement membrane -related genes in lung adenocarcinoma

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Product

Resources

About

Energy Levels and Transitions in⁷¹As from (p, γ) Reaction on⁷⁰Ge