Energy metabolism and substrate oxidation in patients with Crohn’s Disease

Al-Jaouni, Rima; Hébuterne, Xavier; Pouget, Isabelle; Rampal, Patrick

doi:10.1016/s0899-9007(99)00281-6

Cited by 64 publications

(33 citation statements)

References 24 publications

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“…This study showed that measured REE by IC in hospitalized CD patients was 24.4 ± 2.4 kcal/kg/day, and this was significantly higher than that in healthy controls. This result suggests that CD patients apparently have a hyper-metabolic status, and supports observations from previous studies [12–16]. However, mREE was significantly lower than pREE calculated by the Harris-Benedict equation in CD patients.…”

Section: Discussionsupporting

confidence: 91%

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Energy Metabolism in Japanese Patients with Crohn’s Disease

Sasaki

Johtatsu

Kurihara

et al. 2009

J. Clin. Biochem. Nutr.

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We investigated energy expenditure in hospitalized patients with Crohn’s disease (CD), and determined optimal energy requirements for nutritional therapy. Sixteen patients (5 women and 11 men, mean age 36 year old, mean BMI 18.7 kg/m2) and 8 healthy volunteers were enrolled in this study. Measured resting energy expenditure (mREE) levels were determined by indirect calorimetry. The mREEs in CD patients were significantly higher than those of healthy controls (24.4 ± 2.4 kcal/kg/day vs 21.3 ± 1.7 kcal/kg/day). However, mREEs in CD patients were significantly lower than predicted REEs (pREEs) calculated by the Harris-Benedict equation (26.4 ± 2.5 kcal/kg/day). Furthermore, mREE/pREE values were lower in undernourished patients than in well-nourished patients. CD patients had hyper-metabolic statuses evaluated by mREE/body weight, but increased energy expenditure did not contribute to weight loss in these patients. In conclusion, nutritional therapy with 25–30 kcal/ideal body weight/day (calculated by mREE × active factor) may be optimal for active CD patients, while higher energy intake values pose the risk of overfeeding.

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Section: Discussionsupporting

confidence: 91%

“…Energy metabolism changes to a hyper-metabolic status in CD patients [12–16]. However, Melchior et al [17] reported that measured REE (mREE) was approximately 33 kcal/kg/day in patients with CD, which was lower than the REE observed in other diseases.…”

Section: Introductionmentioning

confidence: 99%

Energy Metabolism in Japanese Patients with Crohn’s Disease

Sasaki

Johtatsu

Kurihara

et al. 2009

J. Clin. Biochem. Nutr.

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“…Even though REE tends to decrease in anorexia as a sparing mechanism, some authors found an increase in REE, presumably due to inflammation and body composition changes in IBD patients [26,27,28,29]. Indeed, increased lipid oxidation with a reduction of fat mass and an increase in percentage of lean mass has been shown in children and adults with CD [30,31,32,33]. No relationship between REE and disease activity could be demonstrated in a more recent study [26].…”

Section: Growth Failure In Pediatric Ibdmentioning

confidence: 99%

Impact of Disease and Treatments on Growth and Puberty of Pediatric Patients with Inflammatory Bowel Disease

Ezri¹,

Marques‐Vidal²,

Nydegger³

2012

Digestion

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Growth retardation, associated with delayed puberty, is a frequent feature in pediatric patients with inflammatory bowel disease (IBD), especially with Crohn’s disease. It is mainly induced by malnutrition and the effects of the inflammatory process on the growth hormone/insulin-like growth factor-1 axis or on the growth plate. Therefore, control of disease activity and mucosal healing are paramount to promote growth and adequate pubertal onset. Current therapeutic strategies for maintenance in IBD include anti-inflammatory drugs, immunosuppressives, and, more recently, biologic agents. Although these treatments are efficient in minimizing inflammation and inducing prolonged remission, their long-term effects on growth and final height remain controversial. Furthermore, glucocorticoid therapy, even though very efficient in inducing remission, clearly shows deleterious effects on growth, which is not the case for exclusive enteral nutrition showing comparable results regarding induction of remission. Thus regular assessment of weight, height and pubertal stage is essential in children and adolescents with chronic disease, namely IBD.

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“…For instance, during severe inflammation, energy expenditure is increased and the respiratory quotient is decreased, indicating an increase in whole-body fat oxidation (10)(11)(12)(13)(14). The extent to which PUFA such as 18:2 6 contributes to this inflammation-…”

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confidence: 99%