Proposed near surface habitats on Mars include liquid brines, and fresh water below clear ice. A Europa lander could also encounter water. Some are calling for planetary protection measures to be relaxed (Fairén et al, 2017), Others say we have time to study Mars before Earth life is irreversibly introduced (Rummel et al, 2017).. We argue that when our spacecraft may encounter habitable liquid water, we should aim to be even more ambitious. Some commercial components operate at 300 °C. Building on suggestions from a Venus rover study (Sauder et al, 2017), and a Europa cryobot (Wilcox, 2017), we can aim for 100% heat sterilization during interplanetary flight. In the best case, colliding biospheres could be mutually beneficial, or occupy distinct niches, but in the worst case Earth life has no defences (Lederberg, 1999b) and survives only in enclosed habitats. By examining suggestions for RNA world cells (Szostack, 2016) we argue that the worst case for Mars is extinction of all native life. An astrobiological survey is an essential previous step to inform decisions about whether and how to land humans on Mars. The technology for heavy lift for humans to Mars would permit it to be completed rapidly.