a b s t r a c tWe present a multi-scale framework for the optimal design of CO 2 capture, utilization, and sequestration (CCUS) supply chain network to minimize the cost while reducing stationary CO 2 emissions in the United States. We also design a novel CO 2 capture and utilization (CCU) network for economic benefit through utilizing CO 2 for enhanced oil recovery. Both the designs of CCUS and CCU supply chain networks are multi-scale problems which require decision making at material, process and supply chain levels. We present a hierarchical and multi-scale framework to design CCUS and CCU supply chain networks with minimum investment, operating and material costs. While doing so, we take into consideration the selection of source plants, capture processes, capture materials, CO 2 pipelines, locations of utilization and sequestration sites, and amounts of CO 2 storage. Each CO 2 capture process is optimized, and the best materials are screened from large pool of candidate materials. Our optimized CCUS supply chain network can reduce 50% of the total stationary CO 2 emission in the U.S. at a cost of $35.63 per ton of CO 2 captured and managed. The optimum CCU supply chain network can capture and utilize CO 2 to make a total profit of more than 555 million dollars per year ($9.23 per ton). We have also shown that more than 3% of the total stationary CO 2 emissions in the United States can be eliminated through CCU networks at zero net cost. These results highlight both the environmental and economic benefits which can be gained through CCUS and CCU networks. We have designed the CCUS and CCU networks through (i) selecting novel materials and optimized process configurations for CO 2 capture, (ii) simultaneous selection of materials and capture technologies, (iii) CO 2 capture from diverse emission sources, and (iv) CO 2 utilization for enhanced oil recovery. While we demonstrate the CCUS and CCU networks to reduce stationary CO 2 emissions and generate profits in the United States, the proposed framework can be applied to other countries and regions as well.