1999
DOI: 10.1002/(sici)1098-2787(1999)18:3/4<155::aid-mas1>3.0.co;2-w
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Energy-sensitive cryogenic detectors for high-mass biomolecule mass spectrometry

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Cited by 81 publications
(30 citation statements)
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“…Even though the response time is shorter for STJs (Յ1 s), this can lead to reduced resolution at lower m/z, and finally, (6) the energy resolution of the STJ is limited to charge state determinations of about four. In addition, we and others have also observed a difference in the energy measured at the STJ due to the chemical nature of analyte [22].…”
supporting
confidence: 56%
See 1 more Smart Citation
“…Even though the response time is shorter for STJs (Յ1 s), this can lead to reduced resolution at lower m/z, and finally, (6) the energy resolution of the STJ is limited to charge state determinations of about four. In addition, we and others have also observed a difference in the energy measured at the STJ due to the chemical nature of analyte [22].…”
supporting
confidence: 56%
“…For example, the following analytes were all detected with a STJ cryodetector: polystyrene at 200 kDa and polystyrene aggregates up to 800 kDa [23], polyphenylene dendrimers up to 1 MDa [24], proteins and protein complexes such as anti-human influenza virus he h h maggl g g u l l tin i i i n n n/glutathione i i S-transferase containing an HA tag [AntiHA·GST-HA] ϩ at 150 -400 kDa [25], human immunoglobulin M (IgM) at ϳ1 MDa, and Von Willenbrand factor up to 1 MDa [26]. The principles of the operation of cryodetectors are discussed in detail elsewhere [22,27].…”
mentioning
confidence: 99%
“…Another factor that can limit the sensitivity is related to the micro-channel plate (MCP) impact detector (Frank et al, 1999). The main problem of that detector is that, in all the arrangements unless post-acceleration, its ion transmission is, to some extent, mass-dependent: the sensitivity decreases with an increase in the molecular mass of the analyzed compounds.…”
Section: Sensitivitymentioning
confidence: 99%
“…An interesting solution to overcome this weak point has been proposed by Frank et al (1999) and is based on the use of cryogenic detector. This impact detector measures low-energy solid-state excitations created by a particle impact.…”
Section: Analysis Of Macromoleculesmentioning
confidence: 99%
“…Thus, it has remained an area of rather understated importance, despite the fundamental need to better "see" ions. Only a few groups have recognized the demand for new MS detectors, and only one lone special journal issue on MS detectors has appeared (1)(2)(3)(4). Some initially promising developments, including work on electro-optical arrays, never quite took hold in the MS community (5,6).…”
mentioning
confidence: 99%