The U.S. pharmaceutical industry consumes almost $1 billion in energy annually. Energy efficiency improvement is an important way to reduce these costs and to increase predictable earnings, especially in times of high energy price volatility. There are a variety of opportunities available at individual plants in the U.S. pharmaceutical industry to reduce energy consumption in a cost-effective manner. This Energy Guide discusses energy efficiency practices and energy efficient technologies that can be implemented at the component, process, system, and organizational levels. A discussion of the trends, structure, and energy consumption characteristics of the U.S. pharmaceutical industry is provided along with a description of the major process steps in the pharmaceutical manufacturing process. Expected savings in energy and energy-related costs are given for many energy efficiency measures, based on case study data from real-world applications in pharmaceutical and related facilities worldwide. Typical measure payback periods and references to further information in the technical literature are also provided, when available. The information in this Energy Guide is intended to help energy and plant managers reduce energy consumption in a cost-effective manner while meeting regulatory requirements and maintaining the quality of products manufactured. At individual plants, further research on the economics of the measures-as well as their applicability to different production practices-is needed to assess potential implementation of selected technologies.iv This Energy Guide first describes the trends, structure, and production characteristics of the U.S. pharmaceutical industry. Next, a description of the main production processes and a discussion of energy use in the pharmaceutical industry, including the main end uses of energy, are provided. Due to the wide variety of products and production methods in the U.S. pharmaceutical industry, it is impossible to describe all energy end uses. Therefore, this Energy Guide focuses on the most important end uses of energy in typical U.S. pharmaceutical plants. Finally, the remainder of this Energy Guide discusses opportunities for energy efficiency improvement in U.S. pharmaceutical plants, focusing on energy efficient measures and technologies that have successfully been demonstrated in individual plants in the United States or abroad. Although new energy efficient technologies are developed continuously (see for example Martin et al. 2000), this Energy Guide focuses on those technologies and practices that are both proven and currently commercially available.