This study examines the correlation between the skills and competencies developed in engineering programs and those required by the most representative economic sectors in Medellín for optimizing their production and logistics processes. In general terms, this paper aims to contribute to the research on higher education institutions and the alignment of their programs with the expectations of businesses in emerging countries. Thus, the proposed research question is as follows: What is the systemic relationship between academia and businesses in Colombia regarding the development of skills and competencies related to the optimization of production and logistics processes? To address this question, the study methodology starts by defining the target population (Industrial Engineering and related academic programs) and the dialogue methods adopted. Subsequently, a morphological space is created to establish systemic interconnections among the study variables and factors. Finally, patterns and qualitative/quantitative relationships are identified and grouped into two drivers that support the optimization of production and logistics processes. These drivers, in turn, consist of five key driving variables: quality defects, work environment, information and communication technology usage, operation traceability, and logistics and planning. The results indicate a correlation of 60% between courses and job competencies, 85.71% between academic skills and job competencies, and 71.88% between courses and academic skills. These findings provide insights to enhance cooperation between the academic and business sectors and foster the development of new local competitive capacities.