Engagement of brain areas implicated in processing inner speech in people with auditory hallucinations

Shergill, Sukhwinder S.; Brammer, Michael; Fukuda, Rimmei; Williams, Steven; Murray, Robin M.; McGuire, Philip

doi:10.1192/bjp.182.6.525

Cited by 139 publications

(81 citation statements)

References 31 publications

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“…A relationship between increased FA values of the fronto-occipital and temporolimbic tracts and more severe positive symptoms has been previously observed in nevermedicated patients with schizophrenia 5,10 and in medicated patients with schizophrenia with a history of auditory hallucinations and other positive symptoms. [26][27][28] Overall, these findings suggest that the observed pattern of structural WM changes in patients with schizophrenia is already present before treatment initiation and is associated with the occurrence of positive clinical manifestations. It is worth noting that MD and FA changes may be secondary to modifications of diffusion either parallel (axial diffusivity) or perpendicular (radial diffusivity) to the principal direction of the tensor.…”

Section: Wm Findingsmentioning

confidence: 72%

Patterns of Brain Structural Changes in First-Contact, Antipsychotic Drug-Naïve Patients with Schizophrenia

Filippi

Canu

Gasparotti

et al. 2013

AJNR Am J Neuroradiol

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BACKGROUND AND PURPOSE:Previous studies have suggested that structural changes do occur in the brain of patients with schizophrenia compared with healthy control participants. However, findings from such studies are inconclusive, probably because of the different methodologic approaches, the clinical heterogeneity of patient samples, and also the fact that patients enrolled were treated with antipsychotic drugs. The aim of this study was to investigate brain GM volumes and intrinsic structural WM changes in first-contact, antipsychotic drug-naïve patients with schizophrenia.

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Section: Wm Findingsmentioning

confidence: 72%

Patterns of Brain Structural Changes in First-Contact, Antipsychotic Drug-Naïve Patients with Schizophrenia

Filippi

Canu

Gasparotti

et al. 2013

AJNR Am J Neuroradiol

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“…Again, there is a remarkable correspondence with findings in the literature. Several papers have reported abnormalities in subsets of these regions using a variety of techniques (Gaser et al, 2004;Lennox et al, 1999;Shergill et al, 2003;Sibersweig et al, 1995;Stephane et al, 2001;Weiss & Heckers, 1999). This includes a report from our laboratory showing that volumes of the left middle temporal gyrus were correlated with levels of auditory hallucinations (Onitsuka et al, 2004).…”

Section: Discussionmentioning

confidence: 99%

Functional neuroimaging of word priming in males with chronic schizophrenia

et al. 2007

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Word-priming studies have suggested that the associative disturbance of schizophrenia may reflect aberrant spread of activation through the lexicon of the brain. To explore this, we examined lexical activation using a semantic word-priming paradigm coupled with functional magnetic resonance imaging (fMRI). We also wanted to determine whether brain activation to this paradigm correlated with relevant clinical symptom measures. In addition to completing clinical symptom measures, twelve chronic patients and twelve demographically-matched control subjects completed a lexicaldecision semantic-priming paradigm developed as an event-related BOLD fMRI task. This paradigm consisted of words that differed in connectivity. Words with many connections between shared semantic associates are considered high in connectivity and produce the largest behavioral semantic priming effects in control subjects, while words with few connections between shared semantic associates are considered low in connectivity and produce a relatively smaller amount of semantic priming. In fMRI, a respective step-wise increase in activation from high connectivity to low connectivity to unrelated word pairs was expected for normal subjects. Controls showed the expected pattern of activation to word connectivity; however, patients showed a less robust pattern of activation to word connectivity. Furthermore, this aberrant response correlated with measures of Auditory Hallucinations, Distractive Speech, Illogicality, and Incoherence. The patients did not display left frontal and temporal activation as a function of the degree of word connectivity as seen in healthy controls. This may reflect a disease-related disturbance in functional connectivity of lexical activation, which in turn may be associated with clinical symptomatology.

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“…These findings suggest that a distributed network of cortical and subcortical areas may mediate auditory hallucinations. The notion that auditory hallucinations might be "inner speech" (thinking in words) was very recently taken further by this same group (46). Previous studies have shown that individuals with schizophrenia who were prone to auditory hallucinations demonstrated attenuated activation of brain areas during the monitoring of inner speech.…”

Section: The Neural Correlates Of Symptomsmentioning

confidence: 96%

Insights and treatment options for psychiatric disorders guided by functional MRI

Sharma¹

2003

J. Clin. Invest.

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Engagement of brain areas implicated in processing inner speech in people with auditory hallucinations

Abstract: In people with schizophrenia who are prone to auditory hallucinations, increasing the demands on the processing of inner speech is associated with attenuated engagement of the brain areas implicated in verbal self-monitoring.

Cited by 139 publications

References 31 publications

Patterns of Brain Structural Changes in First-Contact, Antipsychotic Drug-Naïve Patients with Schizophrenia

Patterns of Brain Structural Changes in First-Contact, Antipsychotic Drug-Naïve Patients with Schizophrenia

Functional neuroimaging of word priming in males with chronic schizophrenia

Insights and treatment options for psychiatric disorders guided by functional MRI

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