Insights and treatment options for psychiatric disorders guided by functional MRI

Sharma, Tonmoy

doi:10.1172/jci19166

Cited by 12 publications

(4 citation statements)

References 89 publications

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“…Yet, in order to develop more targeted and effective therapies for schizophrenia, it is crucial to recognize the effects of current treatments on brain function (25). Indeed, the NIMH has recently shifted focus of clinical trials for both pharmacological and non-pharmacological interventions to an experimental therapeutics approach (26), which emphasizes evaluation of the potential for a treatment to engage a hypothesized target (e.g.…”

Section: Introductionmentioning

confidence: 99%

“…Functional neuroimaging is one approach that enables observation of the functional alterations that can occur with a treatment in clinically-relevant timescales (25). Among the techniques in this category, single photon emitted computed tomography (SPECT) and positron emission tomography (PET) have been used to identify changes in brain function, blood flow, metabolism and neuroreceptor and neurotransmitter activity due to drug treatments (27).…”

Section: Introductionmentioning

confidence: 99%

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Converging effects of diverse treatment modalities on frontal cortex in schizophrenia: A review of longitudinal functional magnetic resonance imaging studies

Kani

Shinn

Lewandowski

et al. 2017

Journal of Psychiatric Research

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Objectives A variety of treatment options exist for schizophrenia, but the effects of these treatments on brain function are not clearly understood. To facilitate the development of more effective treatment strategies, it is important to identify how brain function in schizophrenia patients is affected by the diverse therapeutic approaches that are currently available. The aim of the present article is to systematically review the evidence for functional brain changes associated with different treatment modalities for schizophrenia. Methods We searched PubMed for longitudinal functional MRI (fMRI) studies reporting on the effects of antipsychotic medications (APM), repetitive transcranial magnetic stimulation (rTMS), transcranial direct current stimulation (tDCS), cognitive remediation therapy (CRT) and cognitive behavioral therapy for psychosis (CBTp) on brain function in schizophrenia. Results Thirty six studies fulfilled the inclusion criteria. Functional alterations were observed in diverse brain regions. Across intervention modalities, changes in fMRI parameters were reported most commonly in frontal brain regions including prefrontal cortex, anterior cingulate and inferior frontal cortex. Conclusions We conclude that current treatments for schizophrenia commonly induce functional brain alterations in frontal brain regions. However, interpretability is limited by inconsistency in task and region of interest selection, and failures to replicate. Further task independent fMRI studies examining treatment effects with whole brain analysis are needed to deepen our insights.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Converging effects of diverse treatment modalities on frontal cortex in schizophrenia: A review of longitudinal functional magnetic resonance imaging studies

Kani

Shinn

Lewandowski

et al. 2017

Journal of Psychiatric Research

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“…Miscommunication due to inadequate translations between patients and providers often causes negative impact on psychiatric conditions, less effective treatment, and misdiagnoses (Choi et al, 2012; Soller, Chan, & Higa, 2012). The management of psychiatric conditions requires lifelong treatment through psychotropic medications (Harrow, Jobe, & Faull, 2012; Sharma, 2003). Thus, to prevent adverse situations and improve the safety as well as the outcomes of psychiatric patients, it is necessary to provide treatment that is linguistically appropriate (Wilson, 2013).…”

Section: Literature Reviewmentioning

confidence: 99%

Utilization of a Mobile App to Assess Psychiatric Patients With Limited English Proficiency

Villalobos

Lynch

DeBlieck

et al. 2017

Hispanic Journal of Behavioral Sciences

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The interactions in mental health involve a significant exchange of information to identify symptoms and formulate a working diagnosis. The inability of patients to communicate due to language limitations may lead to situations that will be detrimental, such as receiving the wrong diagnosis or treatment due to the inadequate translation from English to Spanish. A practice change was proposed where health care personnel utilized mobile technology such as the Canopy Translation App to assess the psychiatric symptoms of Spanishspeaking patients with limited English proficiency. Participants completed the System Usability Scale (SUS) to determine whether they found the Canopy Translation App useful during their assessments of Spanish-speaking patients. According to the SUS scores, participants found the Canopy Translation App useful during their interactions with Spanish-speaking patients. The findings emphasize the importance of exploring new resources and technologies to ameliorate language barriers.

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“…Although the structural and functional determinants of schizophrenia are areas of active investigation using a wide variety of conventional techniques and approaches, functional-neuroimaging investigation now also suggests new models and possible treatment directions. T. Sharma describes insights into the treatment of schizophrenia that are emerging from neuroimaging investigations (15).…”

Section: Psychiatric Disorders: Insights and Treatment Options Guidedmentioning

confidence: 99%

Imaging and biological function in health and disease

Hirsch

2003

J. Clin. Invest.

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Insights and treatment options for psychiatric disorders guided by functional MRI

Cited by 12 publications

References 89 publications

Converging effects of diverse treatment modalities on frontal cortex in schizophrenia: A review of longitudinal functional magnetic resonance imaging studies

Converging effects of diverse treatment modalities on frontal cortex in schizophrenia: A review of longitudinal functional magnetic resonance imaging studies

Utilization of a Mobile App to Assess Psychiatric Patients With Limited English Proficiency

Imaging and biological function in health and disease

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