Engineered Aedes aegypti JAK/STAT Pathway-Mediated Immunity to Dengue Virus

Jupatanakul, Natapong; Sim, Shuzhen; Angleró-Rodríguez, Yesseinia I.; Souza-Neto, Jayme A.; Das, Suchismita; Poti, Kristin Elizabeth; Rossi, Shannan L.; Bergren, Nicholas A.; Vasilakis, Nikos; Dimopoulos, George

doi:10.1371/journal.pntd.0005187

Cited by 127 publications

(150 citation statements)

References 62 publications

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“…The specialization of the JAK/STAT pathway in mosquitoes was further revealed by a study that showed that the genetically modified strain of A. aegypti could regulate JAK/STAT components to DENV but not to ZIKV or chikungunya virus (CHIKV) infection (Jupatanakul et al . ; McFarlane et al . ).…”

Section: Functional Utilization Of Jak/stat Pathway In Insect Innatementioning

confidence: 99%

“…ND: No available data; Genbank accession numbers are represented in parenthesisRNAi-mediated downregulation of Cactus and PIAS, respectively. The specialization of the JAK/STAT pathway in mosquitoes was further revealed by a study that showed that the genetically modified strain of A. aegypti could regulate JAK/STAT components to DENV but not to ZIKV or chikungunya virus (CHIKV) infection(Jupatanakul et al 2017;McFarlane et al 2014). The JAK/STAT pathway core components under the ligands, receptor, kinases, and substrates category for A. aegypti have been shown inTable 4.…”

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confidence: 99%

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JAK/STAT signaling in insect innate immunity

Bang

2019

Entomological Research

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Lack of an adaptive strategy to combat infection creates opportunities for the innate immune system to guide invertebrate defense mechanisms. The innate immunity signaling cascades in invertebrates are elaborate, complex, and pathogen‐specific. Among invertebrates, the most extended repertoire of molecules that function in the regulatory signaling pathways has been observed in insects. This is highlighted by the fact that antimicrobial peptide (AMP) production against pathogens is orchestrated through diverse immune pathways, either independently or through cross‐talk mechanisms. The Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway coordinates immune responses from cytokines and regulates multiple homeostasis mechanisms in the host. That pathway has been implicated in the regulation of cell growth, differentiation, apoptosis, and inflammatory reactions. Many novel therapeutic interventions for tumors have been aimed at inhibitors of the JAK/STAT cascade. The regulatory pathway has much fewer components in Drosophila, and human homologs of almost all the critical pathway components and negative regulators have been identified. Loss‐of‐function mutation analysis and RNA interference‐based gene silencing modeling have produced functional characterization of the core components and negative regulators in Drosophila melanogaster, Aedes aegypti, and Anopheles gambiae, and in some hymenopteran and lepidopteran species. The genome‐wide analysis of the coleopteran species, Tribolium castaneum and Tenebrio molitor have been explored for elucidation of their JAK/STAT pathway regulatory components. Considering the promise of the JAK/STAT pathway in the mammalian model, the regulatory pathway in insects seems interesting especially for understanding pathogen surveillance mechanisms.

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Section: Functional Utilization Of Jak/stat Pathway In Insect Innatementioning

confidence: 99%

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confidence: 99%

JAK/STAT signaling in insect innate immunity

Bang

2019

Entomological Research

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“…It has also been reported that Aag-2 cells (a cell line of A. aegypti ) increase quantitatively with the expression of the STAT transcription factor during infections by SINV [66]. The activation of the JAK-STAT pathway does not favor per se resistance to ZIKV or CHIKV but does indeed do so in relation to DENV [89]. When combined with the Toll pathway, the JAK-STAT pathway enhances resistance to ZIKV in A. aegypti [90].…”

Section: The Immune Response In a Aegyptimentioning

confidence: 99%

Molecular Basis for Arbovirus Transmission by <b><i>Aedes aegypti</i></b> Mosquitoes

et al. 2018

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Mosquitoes are considered the most important vectors for the transmission of pathogens to humans. Aedes aegypti is a unique species, not only by its highly anthropophilic and peridomestic habits but also because it can transmit an important variety of pathogenic viruses. Examples are dengue, yellow fever, chikungunya, Zika, and Mayaro viruses. After ingesting viremic blood, a wide range of mechanisms are activated in the mosquito to counteract viral infection. Nevertheless, these arboviruses possess strategies to overcome barriers in the mosquito and eventually reach the salivary glands to continue the transmission cycle. However, the infection and eventual transmission of arbovirus depends on multiple factors. The current review focuses in detail on the anatomic, physiological, and molecular characteristics of the mosquito A. aegypti that participate in response to a viral infection. In the past decades, the awareness of the importance of this mosquito as a disease vector and its impact on human health was largely recognized. We need to improve our comprehension of molecular mechanisms that determine the outcome of successful virus replication or control of infection for each arbovirus in the vector; this could lead to the design of effective control strategies in the future.

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“…However, this inhibition is far from complete. 40 RNA interference (RNAi) gene silencing is an important antiviral mechanism in Ae. aegypti.…”

Section: Artículo De Revisiónmentioning

confidence: 99%

Pathogen-insect interaction candidate molecules for transmission-blocking control strategies of vector borne diseases

Zumaya-Estrada¹,

Rodríguez²,

Rodrı́guez³

2017

Salud Publica Mex

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Zumaya ResumenObjetivo. Analizar el conocimiento actual de las interacciones patógeno-insecto susceptibles a incluirse en el diseño de estrategias moleculares para el control de enfermedades transmitidas por vectores. Material y métodos. Se examinaron los agentes causales de la malaria, el dengue y la enfermedad de Chagas, y las moléculas de insectos que participan en interacciones durante la infección de sus vectores. Resultados. Se presentan moléculas de patógenos que participan en la invasión del intestino del insecto y moléculas inmunes inducidas en los vectores. Se discute su inclusión en vacunas bloqueadoras de transmisión (VBT) y en la modificación genética de vectores (MGI) o de sus bacterias simbióticas. Conclusión. La interrupción de procesos mediante el bloqueo de las interacciones patógeno-vector proporciona varios candidatos para las estrategias de control molecular, pero la eficacia de VBT y MGI es aún limitada y los efectos secundarios de MGI (aumento de la transmisión de otros patógenos y afectación de otros organismos) deben descartase.

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Engineered Aedes aegypti JAK/STAT Pathway-Mediated Immunity to Dengue Virus

Cited by 127 publications

References 62 publications

JAK/STAT signaling in insect innate immunity

JAK/STAT signaling in insect innate immunity

Molecular Basis for Arbovirus Transmission by <b><i>Aedes aegypti</i></b> Mosquitoes

Pathogen-insect interaction candidate molecules for transmission-blocking control strategies of vector borne diseases

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