Engineered cell-degradable poly(2-alkyl-2-oxazoline) hydrogel for epicardial placement of mesenchymal stem cells for myocardial repair

You, Yaqi; Kobayashi, Kosaku; Colak, Burcu; Luo, Piaopiao; Cozens, Edward J.; Fields, Laura; Suzuki, Ken; Gautrot, Julien E.

doi:10.1016/j.biomaterials.2020.120356

Cited by 60 publications

(57 citation statements)

References 79 publications

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“…The results showed that the loading of CPX did not affect the stiffness, biocompatibility, and adhesive strength of hydrogels, suggesting a potential solution to seal corneal wounds without being infected. You et al (2021 ) designed poly (2-ethyl-2-oxazoline-co-2-butenyl-2-oxazoline) (POx) hydrogels encapsulating mesenchymal stromal cells (MSCs). The thiol-ene crosslinked hydrogels exhibited great tissue adhesive strength.…”

Section: Prospect Of Biomedical Polymers and Potential Technologymentioning

confidence: 99%

Recent Advances of Biomedical Materials for Prevention of Post-ESD Esophageal Stricture

Bao

et al. 2021

Front. Bioeng. Biotechnol.

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Esophageal stricture commonly occurs in patients that have suffered from endoscopic submucosal dissection (ESD), and it makes swallowing difficult for patients, significantly reducing their life qualities. So far, the prevention strategies applied in clinical practice for post-ESD esophageal stricture usually bring various inevitable complications, which drastically counteract their effectiveness. Nowadays, with the widespread investigation and application of biomedical materials, lots of novel approaches have been devised in terms of the prevention of esophageal stricture. Biomedical polymers and biomedical-derived materials are the most used biomedical materials to prevent esophageal stricture after ESD. Both of biomedical polymers and biomedical-derived materials possess great physicochemical properties such as biocompatibility and biodegradability. Moreover, some biomedical polymers can be used as scaffolds to promote cell growth, and biomedical-derived materials have biological functions similar to natural organisms, so they are important in tissue engineering. In this review, we have summarized the current approaches for preventing esophageal stricture and put emphasis on the discussion of the roles biomedical polymers and biomedical-derived materials acted in esophageal stricture prevention. Meanwhile, we proposed several potential methods that may be highly rational and feasible in esophageal stricture prevention based on other researches associated with biomedical materials. This review is expected to offer a significant inspiration from biomedical materials to explore more effective, safer, and more economical strategies to manage post-ESD esophageal stricture.

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Section: Prospect Of Biomedical Polymers and Potential Technologymentioning

confidence: 99%

Recent Advances of Biomedical Materials for Prevention of Post-ESD Esophageal Stricture

Bao

et al. 2021

Front. Bioeng. Biotechnol.

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“…Polymers of cyclic imino ethers, particularly poly(2-oxazoline)s (POx) and poly(2-oxazine)s (POzi) [ 21 ] with a thermoresponsive profile [ 22 , 23 ] have attained significant attention in the past decade [ 23 , 24 ]. POx has shown huge potential in tissue engineering [ 25 , 26 , 27 , 28 , 29 ], drug delivery [ 30 , 31 , 32 , 33 , 34 , 35 ] and 3D (bio) printing [ 24 , 36 ]. They are structural isomers of polypeptides, are synthetically relatively easily accessed and are highly tunable in their physico-chemical characteristics [ 37 ].…”

Section: Introductionmentioning

confidence: 99%

“…A plethora of studies show the utilization of pMeOx and pEtOx as hydrophilic polymer for the development of hydrogels [ 28 , 47 , 48 , 49 ], electrospun fibres [ 50 ], polymer brushes [ 51 ], nanoparticles [ 52 ], micelles for drug delivery [ 53 , 54 , 55 , 56 , 57 ] and for melt electrowriting [ 58 , 59 ]. Bloksma et al also investigated the thermoresponsive behaviour of few POzi based homopolymers [ 22 ].…”

Section: Introductionmentioning

confidence: 99%

Tuning the Thermogelation and Rheology of Poly(2-Oxazoline)/Poly(2-Oxazine)s Based Thermosensitive Hydrogels for 3D Bioprinting

Haider¹,

Ahmad

Yang³

et al. 2021

Gels

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As one kind of “smart” material, thermogelling polymers find applications in biofabrication, drug delivery and regenerative medicine. In this work, we report a thermosensitive poly(2-oxazoline)/poly(2-oxazine) based diblock copolymer comprising thermosensitive/moderately hydrophobic poly(2-N-propyl-2-oxazine) (pPrOzi) and thermosensitive/moderately hydrophilic poly(2-ethyl-2-oxazoline) (pEtOx). Hydrogels were only formed when block length exceeded certain length (≈100 repeat units). The tube inversion and rheological tests showed that the material has then a reversible sol-gel transition above 25 wt.% concentration. Rheological tests further revealed a gel strength around 3 kPa, high shear thinning property and rapid shear recovery after stress, which are highly desirable properties for extrusion based three-dimensional (3D) (bio) printing. Attributed to the rheology profile, well resolved printability and high stackability (with added laponite) was also possible. (Cryo) scanning electron microscopy exhibited a highly porous, interconnected, 3D network. The sol-state at lower temperatures (in ice bath) facilitated the homogeneous distribution of (fluorescently labelled) human adipose derived stem cells (hADSCs) in the hydrogel matrix. Post-printing live/dead assays revealed that the hADSCs encapsulated within the hydrogel remained viable (≈97%). This thermoreversible and (bio) printable hydrogel demonstrated promising properties for use in tissue engineering applications.

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“…Polymers of cyclic imino ethers, particularly poly(2-oxazoline)s (POx) and poly(2-oxazine)s (POzi) [19] with a thermoresponsive profile [20,21] have attained significant attention in the past decade [21,22]. POx has shown huge potential in tissue engineering [23][24][25][26], drug delivery [27][28][29][30][31][32][33] and 3D (bio) printing [22,34]. They are structural isomers of polypeptides, are synthetically relatively easily accessed and are highly tunable in their physico-chemical characteristics [35].…”

Section: Introductionmentioning

confidence: 99%

“…A plethora of studies show the utilization of pMeOx and pEtOx as hydrophilic polymer for the development of hydrogels [26,[45][46][47], electrospun fibres [48], polymer brushes [49], nanoparticles [50], micelles for drug delivery [51][52][53][54][55][56] and for melt electrowriting [57]. Bloksma et al also investigated the thermoresponsive behaviour of few POzi based homopolymers [20].…”

Section: Introductionmentioning

confidence: 99%

Tuning the Thermogelation and Rheology of Poly(2-Oxazoline)/poly(2-Oxazine)s Based Thermosensitive Hydrogels for 3D Bioprinting.

Haider¹,

Taufiq²,

Yang³

et al. 2021

Preprint

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As one kind of smart material, thermogelling polymers find applications in biofabrication, drug delivery and regenerative medicine. Here, we reported on a novel thermosensitive hydrogel which can be 3D printed using extrusion based printing. Gel strength was found around 3kPa storage modulus with pronounced shear thinning and rapid recovery after stress. Addition of clay nanoparticles (Laponite XLG) improved the rheological profile further. Human adipose derived stem cells were added to the hydrogel matrix, which remained fully viable after printing. Therefore, the presented materials adds to the available material toolbox for 3D bioprinting. <br>

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Engineered cell-degradable poly(2-alkyl-2-oxazoline) hydrogel for epicardial placement of mesenchymal stem cells for myocardial repair

Cited by 60 publications

References 79 publications

Recent Advances of Biomedical Materials for Prevention of Post-ESD Esophageal Stricture

Recent Advances of Biomedical Materials for Prevention of Post-ESD Esophageal Stricture

Tuning the Thermogelation and Rheology of Poly(2-Oxazoline)/Poly(2-Oxazine)s Based Thermosensitive Hydrogels for 3D Bioprinting

Tuning the Thermogelation and Rheology of Poly(2-Oxazoline)/poly(2-Oxazine)s Based Thermosensitive Hydrogels for 3D Bioprinting.

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