Engineered Exosomes-Mediated Transfer of hsa-miR-320a Overcomes Chemoresistance in Cervical Cancer Cells via Targeting MCL1

Zhou, Jinling; Wang, Yuanhe; Zhang, Lizhu; Chen, Qin; Zhu, Xiaojun; Jiang, Peiyue; Jiang, Nan; Zhao, Wei; Li, Baohua

doi:10.3389/fphar.2022.883445

Cited by 5 publications

(2 citation statements)

References 24 publications

(28 reference statements)

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“…Exosomes derived from miR-221-3p mimic-transfected CC cells promoted invasion, migration, and angiogenesis of CC cells through downregulation of MAPK10 116 and lymphangiogenesis and lymphatic metastasis of HLECs by targeting VASH1 117 . miR-320a expression was decreased in CC tissues, and engineered miR-320a exosomes enhanced the chemoresistance and tumor growth by targeting MCL1 118 .…”

Section: Exosomes In CCmentioning

confidence: 98%

The Role and Applications of Exosomes in Gynecological Cancer: A Review

Wang,

Ding

2023

Cell Transplant

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Exosomes are phospholipid bilayer vesicles that are released by all types of cells, containing proteins, lipids, and nucleic acids such as DNAs and RNAs. Exosomes can be transferred between cells and play a variety of physiological and pathological regulatory functions. Noncoding RNAs, including micro RNAs, long noncoding RNAs, and circular RNAs, are the most studied biomolecules from exosomes and more and more studies found that noncoding RNAs play an important role in the diagnosis, prognosis, and treatment of diseases, including various types of cancer. Gynecological malignancies such as ovarian, endometrial, and cervical cancer seriously threaten women’s life. Therefore, this article reviews the roles and applications of exosomes in gynecological malignancies, including the promotion or inhibition of tumor progression and regulation of tumor microenvironments, and as potential therapeutic targets for treating gynecological cancers.

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Section: Exosomes In CCmentioning

confidence: 98%

The Role and Applications of Exosomes in Gynecological Cancer: A Review

Wang,

Ding

2023

Cell Transplant

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“…Zhou et al found that miR-320a expression was low in cisplatin-resistant CC. Myeloid Cell Leukemia Sequence 1, a cisplatin-resistant molecule, was regulated by engineered miR-320a EVs, thereby reducing resistance to cisplatin therapy in CC [ 74 ].…”

Section: Progress In the Treatment Of Evs In CCmentioning

confidence: 99%

Application of Extracellular Vesicles in Gynecologic Cancer Treatment

2022

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Ovarian, cervical, and endometrial cancer are the three most common gynecological malignancies that seriously threaten women’s health. With the development of molecular biology technology, immunotherapy and targeted therapy for gynecologic tumors are being carried out in clinical treatment. Extracellular vesicles are nanosized; they exist in various body fluids and play an essential role in intercellular communication and in the regulation of various biological process. Several studies have shown that extracellular vesicles are important targets in gynecologic cancer treatment as they promote tumor growth, progression, angiogenesis, metastasis, chemoresistance, and immune system escape. This article reviews the progress of research into extracellular vesicles in common gynecologic tumors and discusses the role of extracellular vesicles in gynecologic tumor treatment.

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Plant‐Derived Extracellular Vesicles as Potential Emerging Tools for Cancer Therapeutics

Ding,

Chang,

Liang

et al. 2024

Advanced Therapeutics

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Extracellular vesicles (EVs) are membranous structures secreted by cells that play important roles in intercellular communication and material transport. Due to its excellent biocompatibility, lipophilicity, and homing properties, EVs have been used as a new generation of drug delivery systems for the diagnosis and treatment of tumors. Despite the potential clinical benefits of animal‐derived extracellular vesicles (AEVs), their large‐scale production remains sluggish due to the exorbitant cost of cell culture, challenging quality control measures, and limited production capabilities. This constraint significantly hinders their widespread clinical application. Plant‐derived extracellular vesicles (PEVs) share similar functionalities with AEVs, yet they hold several advantages including a wide variety of source materials, cost‐effectiveness, ease of preparation, enhanced safety, more stable physicochemical properties, and notable efficacy. These merits position PEVs as promising contenders with broad potential in the biomedical sector. This review will elucidate the advantages of PEVs, delineating their therapeutic mechanisms in cancer treatment, and explore the prospective applications of engineered PEVs as targeted delivery nano‐system for drugs, microRNAs, small interfering RNAs, and beyond. The aim is to heighten researchers’ focus on PEVs and expedite the progression from fundamental research to the transformation of groundbreaking discoveries.

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Engineered Exosomes-Mediated Transfer of hsa-miR-320a Overcomes Chemoresistance in Cervical Cancer Cells via Targeting MCL1

Cited by 5 publications

References 24 publications

The Role and Applications of Exosomes in Gynecological Cancer: A Review

The Role and Applications of Exosomes in Gynecological Cancer: A Review

Application of Extracellular Vesicles in Gynecologic Cancer Treatment

Plant‐Derived Extracellular Vesicles as Potential Emerging Tools for Cancer Therapeutics

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