2022
DOI: 10.1083/jcb.202106179
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Engineered kinases as a tool for phosphorylation of selected targets in vivo

Abstract: Reversible protein phosphorylation by kinases controls a plethora of processes essential for the proper development and homeostasis of multicellular organisms. One main obstacle in studying the role of a defined kinase–substrate interaction is that kinases form complex signaling networks and most often phosphorylate multiple substrates involved in various cellular processes. In recent years, several new approaches have been developed to control the activity of a given kinase. However, most of them fail to regu… Show more

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Cited by 2 publications
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